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Total Synthesis of (-)-Nodulisporic Acid D.
J Am Chem Soc. 2015 Jun 10;137(22):7095-8
Authors: Zou Y, Melvin JE, Gonzales SS, Spafford MJ, Smith AB
Abstract
A convergent total synthesis of the architecturally complex indole diterpenoid (-)-nodulisporic acid D has been achieved. Key synthetic transformations include vicinal difunctionalization of an advanced α,β-unsaturated aldehyde to form the E,F-trans-fused 5,6-ring system of the eastern hemisphere and a cascade cross-coupling/indolization protocol leading to the CDE multisubstituted indole core.
PMID: 26029849 [PubMed - indexed for MEDLINE]
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