Normal Taste Acceptance and Preference of PANX1 Knockout Mice.

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Normal Taste Acceptance and Preference of PANX1 Knockout Mice.

Chem Senses. 2015 Sep;40(7):453-9

Authors: Tordoff MG, Aleman TR, Ellis HT, Ohmoto M, Matsumoto I, Shestopalov VI, Mitchell CH, Foskett JK, Poole RL

Abstract
Taste compounds detected by G protein-coupled receptors on the apical surface of Type 2 taste cells initiate an intracellular molecular cascade culminating in the release of ATP. It has been suggested that this ATP release is accomplished by pannexin 1 (PANX1). However, we report here that PANX1 knockout mice do not differ from wild-type controls in response to representative taste solutions, measured using 5-s brief-access tests or 48-h two-bottle choice tests. This implies that PANX1 is unnecessary for taste detection and consequently that ATP release from Type 2 taste cells does not require PANX1.

PMID: 25987548 [PubMed - indexed for MEDLINE]

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