Mitochondrial Antigen Presentation: A Vacuolar Path to Autoimmunity in Parkinson's Disease

Publication date: Available online 13 September 2016
Source:Trends in Immunology
Author(s): Pascale Baden, Michela Deleidi
Mitochondrial antigens can be presented by MHC molecules and initiate adaptive immune responses but the mechanisms of mitochondrial antigen presentation (MitAP) have remained mostly unknown. A recent study proposes a new model whereby MitAP is mediated by a vesicle transport pathway that is suppressed by the Parkinson's disease (PD) associated proteins PTEN-induced putative kinase 1 (PINK1) and Parkin. This discovery brings a new perspective on the link between mitochondrial dysfunction and autoimmunity in PD.



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