Lnc-ing ROR1–HER3 and Hippo signalling in metastasis:
Nature Cell Biology 19, 81 (2017).
doi:10.1038/ncb3467
Authors: Wei Zhuo & Yibin Kang
Long noncoding RNAs (lncRNAs) are increasingly recognized for their role in cancer progression. The previously uncharacterized lncRNA MAYA is now shown to promote bone metastasis by bridging ROR1–HER3 and Hippo–YAP pathways. Neuregulin-induced HER3 phosphorylation by ROR1 recruits a MAYA-containing protein complex to methylate Hippo/MST1 and activate YAP target genes that are essential for bone metastasis.
http://ift.tt/2kfiAEa
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δημοφιλείς αναρτήσεις
-
Abstract In the interventional treatment of tricuspid valve regurgitation, the majority of prosthetic devices interact with or are implant...
-
The versatility of the thoracodorsal artery based composite flaps with vascularized rib and a systematic... The versatility of the thoracodo...
-
Correction to: Long-term results of stapled hemorrhoidectomy Unfortunately, there is a spelling mistake in the 2nd sentence of the 2nd parag...
-
A novel potassium oxalate-based hydrogel is proposed for treating dentin hypersensitivity and this study evaluates its in vitro performance...
-
Publication date: 1 October 2017 Source: Appetite, Volume 117 Author(s): Cheryl L. Rock, Shirley W. Flatt, Hava-Shoshana Barkai, Bilge Pak...
-
A rare case of an intramedullary metastasis of a myxopapillary ependymoma Category: Unique Case Observations Article type: Case Report Autho...
-
Influence of red mud on mechanical and durability performance of self-compacting concrete Publication date: 5 November 2019 Source: Journal...
-
Smelling Anxiety Chemosignals Impairs Clinical Performance of Dental Students. Chem Senses. 2018 May 15;: Authors: Singh PB, Young A,...
-
Abstract Purpose Music has recognized beneficial effects on cancer patients; however, very little is known about the molecular processes...
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου