Biomarkers in Chronic Rhinosinusitis with Nasal Polyps.

Biomarkers in Chronic Rhinosinusitis with Nasal Polyps.

Immunol Allergy Clin North Am. 2018 Nov;38(4):679-692

Authors: Workman AD, Kohanski MA, Cohen NA

Abstract
Chronic rhinosinusitis is a complex disease that exists along the inflammatory spectrum between types 1 and 2 inflammation. The classic phenotypic differentiation of chronic rhinosinusitis based on the presence or absence of inflammatory polyps remains one of the best differentiators of response to therapy. Development of biologics for the treatment of atopic disease and asthma and topical therapies for sinusitis have placed renewed emphasis on understanding the pathophysiology of polyp disease. Identification of key markers of polyposis will allow for better stratification of inflammatory polyp disease endotypes to objectively identify medical therapies and track response to treatment.

PMID: 30342588 [PubMed - in process]

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