Sofosbuvir‐based Therapy for Late Pregnant Women and Infant with Severe Chronic Hepatitis C: A Case Series Study

alexandrossfakianakis shared this article with you from Inoreader Sofosbuvir‐based Therapy for Late Pregnant Women and Infant with Severe Chronic Hepatitis C: A Case Series Study via Journal of Medical Virology ABSTRACT Data on sofosbuvir-based therapy for pregnant women and infant with severe chronic hepatitis C (CHC) are lacking. Two late pregnant women and one female infant with severe CHC were enrolled for treatment. Pregnant women 1 and 2 and infant 3 were 30, 33, and 1.2 years old, respectively; the gestational ages of pregnant women 1 and 2 were 31 and 26 weeks, respectively. Notably, pregnant women 1 and 2 and infant 3 had hepatitis C virus (HCV) RNA levels of 139000, 198000, and 8450000 IU/ml; alanine aminotransferase levels of 420, 781, and 220 U/L; and received sofosbuvir/ledipasvir, sofosbuvir/velpatasvir, and sofosbuvir/ledipasvir for 12 weeks, respectively. All three patients were safely cured with favorable tolerance, and two newborns were both breastfeeding and were consistently negative for the anti-HCV antibody during the one-year follow-up after birth. Additionally, two newborns and infant 3 had normal growth parameters during the follow-up year one. In c onclusion, this case series study found that sofosbuvir-based therapy for pregnant women and infant with severe CHC is safe and effective. The data may fill the gap and provide evidence of the use of sofosbuvir-based therapy as a reference when similar severe CHC situations are encountered during clinical practice. This article is protected by copyright. All rights reserved. View on Web

Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.