Genome Biology : New research on MSRA, Ancestry-based healthcare

Genome Biology Impact Factor: 11.313   Genome Biology Impact Factor: 11.313     Submit Manuscript  |  Editorial Board  |  Submission Guidelines  |  Article Alerts   Dear Dr Sfakianakis, We are pleased to share with you our July content update, featuring journal news, top articles and our most recent table of contents. Journal News Meet the editors: We have a busy few months of travel coming up. Senior Editor Andrew Cosgrove will be attending Genome Science (Aug 30 – Sept 1, Liverpool, UK) and Genome Informatics (Sept 19-22, Hinxton, UK), Chief Editor Louisa Flintoft will be attending Microbiome and Disease (Sept 7-9, Hinxton, UK), Assistant Editor Dominique Morneau will be attending Single Cell Genomics (Sept 14-16, Hinxton, UK), and Associate Editor Barbara Cheifet will be attending Genomics of Common Diseases (Sept 25-28, Baltimore, USA). Email us if you would like to arrange a meeting. Featured Articles Ancestry-based healthcare inequality The concentration of genomic data from people with European ancestry causes healthcare inequality by obstructing the identification of disease variants in non-European groups, impeding diagnosis of genetic disorders. Origin and spread of MRSA ST59 is an epidemic MRSA clone found primarily in East Asia, responsible for extensive morbidity and mortality. This study resolves the controversial geographic origin and spread of ST59. Sex-differences across complex traits Gene-by-sex interactions and genetic heterogeneity among sexes are small but common features of high-level complex traits in humans, including anthropometric, cognitive, and cardiovascular phenotypes. Table Of Contents Comment RESEARCH HIGHLIGHT Comparative genomics provides insight into maize adaptation in temperate regions Matthew B. Hufford RESEARCH HIGHLIGHT Mendelian randomization in (epi)genetic epidemiology: an effective tool to be handled with care Antti Latvala and Miina Ollikainen RESEARCH HIGHLIGHT A guide to translation of research results from model organisms to human Ross C. Hardison MEETING REPORT Virus genomics and evolution: the transformative effect of new technologies and multidisciplinary collaboration on virus research and outbreak management Camilla L. C. Ip et al. Research RESEARCH Evaluation of off-target and on-target scoring algorithms and integration into the guide RNA selection tool CRISPOR Maximilian Haeussler et al. RESEARCH The mRNA-bound proteome of the human malaria parasite Plasmodium falciparum Evelien M. Bunnik et al. RESEARCH Enhancers reside in a unique epigenetic environment during early zebrafish development Lucas J. T. Kaaij et al. RESEARCH Single-cell genome-wide bisulfite sequencing uncovers extensive heterogeneity in the mouse liver methylome Silvia Gravina et al. RESEARCH Gene-specific patterns of expression variation across organs and species Alessandra Breschi et al. RESEARCH A comprehensive study of the genomic differentiation between temperate Dent and Flint maize Sandra Unterseer et al. RESEARCH Integrating epigenomic data and 3D genomic structure with a new measure of chromatin assortativity Vera Pancaldi et al. RESEARCH Widespread parainflammation in human cancer Dvir Aran et al. RESEARCH Mapping H4K20me3 onto the chromatin landscape of senescent cells indicates a function in control of cell senescence and tumor suppression through preservation of genetic and epigenetic stability David M. Nelson et al. RESEARCH Identification of source and sink populations for the emergence and global spread of the East-Asia clone of community-associated MRSA Melissa J. Ward et al. RESEARCH Integrative epigenomic analysis reveals unique epigenetic signatures involved in unipotency of mouse female germline stem cells Xiao-Li Zhang et al. RESEARCH Evidence for sex-specific genetic architectures across a spectrum of human complex traits Konrad Rawlik et al. RESEARCH Characterizing human lung tissue microbiota and its relationship to epidemiological and clinical features Guoqin Yu et al. RESEARCH Selected heterozygosity at cis-regulatory sequences increases the expression homogeneity of a cell population in humans Min Kyung Sung et al. METHOD GiniClust: detecting rare cell types from single-cell gene expression data with Gini index Lan Jiang et al. METHOD Ligation-free ribosome profiling of cell type-specific translation in the brain Nicholas Hornstein et al. OPEN LETTER Unequal representation of genetic variation across ancestry groups creates healthcare inequality in the application of precision medicine Slavé Petrovski and David B. Goldstein CORRESPONDENCE High type II error and interpretation inconsistencies when attempting to refute transgenerational epigenetic inheritance Carlos Guerrero-Bosagna CORRESPONDENCE High type I error and misrepresentations in search for transgenerational epigenetic inheritance: response to Guerrero-Bosagna Khursheed Iqbal et al. ERRATUM Erratum to: The shocking consequences of hybrid epigenomes William T. Jordan and Robert J. 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