Low etiologic fraction for human papillomavirus in larynx squamous cell carcinoma

Low etiologic fraction for human papillomavirus in larynx squamous cell carcinoma: Human papillomavirus (HPV) type 16 is an established cause of oropharyngeal squamous cell carcinoma (OPSCC) [1]. However, two meta-analyses and worldwide surveys observe substantial variability in the proportion of OPSCC attributable to HPV infection across geographic regions [2,3]. Of considerable public health interest is the proportion of non-oropharyngeal, head and neck squamous cell carcinomas (HNSCC) that may be attributable to HPV infection, as they may be theoretically preventable with HPV vaccines.




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