Androgen Deprivation Therapy and Subsequent Dementia

To the Editor The recent article in JAMA Oncology by Nead et al possibly helps to answer an important long-standing clinical question about the role of luteinizing hormone (LH) in Alzheimer disease. Alzheimer disease and other dementias are more common in the elderly population. Elderly postmenopausal women and men who have undergone orchiectomy normally have elevated levels of LH. Previous work had implicated high LH levels in the pathogenesis of Alzheimer disease. If this hypothesis were correct, interventions that lower LH levels could conceivably lower the risk of Alzheimer disease. Importantly, the data of Nead et al seem to contradict this concept.

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