Chemokine (CC motif) ligand 18 upregulates Slug expression to promote stem ‐cell like features by activating the mammalian target of rapamycin pathway in oral squamous cell carcinoma

Chemokine (CC motif) ligand 18 upregulates Slug expression to promote stem ‐cell like features by activating the mammalian target of rapamycin pathway in oral squamous cell carcinoma: In conclusion, our data suggested that CCL18 upregulated Slug expression to promote EMT and stem cell‐like features by activating the mTOR pathway in oral cancer. These findings provide new potential targets for the early diagnosis and treatment of OSCC.

The study provided evidence that elevated CCL18 induced migration, invasion, epithelial‐mesenchymal transition (EMT), and the obtain of cancer stem‐cell like characteristics in OSCC cells. Moreover, we found that these CCL18‐derived responses were initiated by Slug overexpression via stimulating the mTOR signaling pathway in OSCC. (Source: Cancer Science)

http://ift.tt/2vhdBaT