Nicotinamide adenine dinucleotide (NAD(+) ) is a ubiquitous metabolite that serves an essential role in the catabolism of nutrients. Recently there has been a surge of interest in NAD(+) biology, with the recognition that NAD(+) influences many biological processes beyond metabolism, including transcription, signalling and cell survival. There are a multitude of pathways involved in the synthesis and breakdown of NAD(+) , and alterations in NAD(+) homeostasis have emerged as a common feature of a range of disease states. Here we provide an overview of NAD(+) metabolism and summarise progress on the development of NAD(+) -related therapeutics.

NAD(+) : a key metabolic regulator with great therapeutic potential.:

Related Articles

NAD(+) : a key metabolic regulator with great therapeutic potential.

J Neuroendocrinol. 2017 Jul 18;:

Authors: Sultani G, Samsudeen AF, Osborne B, Turner N

Abstract

Nicotinamide adenine dinucleotide (NAD(+) ) is a ubiquitous metabolite that serves an essential role in the catabolism of nutrients. Recently there has been a surge of interest in NAD(+) biology, with the recognition that NAD(+) influences many biological processes beyond metabolism, including transcription, signalling and cell survival. There are a multitude of pathways involved in the synthesis and breakdown of NAD(+) , and alterations in NAD(+) homeostasis have emerged as a common feature of a range of disease states. Here we provide an overview of NAD(+) metabolism and summarise progress on the development of NAD(+) -related therapeutics. This article is protected by copyright. All rights reserved.

PMID: 28718934 [PubMed - as supplied by publisher]

http://ift.tt/2tKAEsN