A number of retrospective and prospective series have assessed local control outcomes of brain metastases based on primary histology.1–4 These studies have revealed mixed results, with some studies showing poorer local control with histologies typically classified as radioresistant, including melanoma and renal cell cancers. The current determinants of stereotactic radiation dose are lesion size and receipt of previous radiation treatment.5 Histology does not routinely play a primary role in the determination of radiation dose.
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