Liver Injury After Invariant NKT Cell Activation by Free Alpha-galactosylceramide and Alpha-galactosylceramide-loaded Dendritic Cells:
Background/Aim: Both free alpha-galactosylceramide (αGalCer) and αGalCer-loaded dendritic cells (DCG) activate invariant natural killer T (iNKT) cells to varying degrees, with αGalCer inducing liver injury. We sought to evaluate liver injury by these two pathways. Materials and Methods: Mice were injected with αGalCer or DCG followed by analysis of serum alanine transaminase (ALT) activity levels, mortality and liver function. Results: While ALT levels were elevated after DCG in a tumor necrosis factor (TNF)-α-dependent manner, DCG did not cause lethal injury. More serious injury of liver CD31-positive endothelial cells (CD31+ EC) was observed in mice treated with αGalCer than with DCG. Furthermore, liver CD31+ EC of αGalCer-treated mice induced naïve liver lymphocytes to produce TNF-α. Conclusion: DCG treatment did not induce lethal liver injury. CD31+ EC may play an antigen-presenting role to iNKT cells after αGalCer treatment and may be a cause of lethal injury.
http://ift.tt/291oJmc
Ιατρική : Τα αισθητικά συστήματα της όρασης,ακοής,αφής,γεύσης και όσφρησης.
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δημοφιλείς αναρτήσεις
-
[PDF] Καρκίνος του στομάχου -- Αλέξανδρος Γ. Σφακιανάκης Αναπαύσεως 5 Άγιος Νικόλαος Λασιθίου 72100 2841026182
-
A Genome‐wide Association Study of Prostate Cancer in Latinos Latinos represent less than 1% of samples analyzed to date in genome‐wide asso...
-
Does CBD Oil Lower Blood Pressure? This article was originally published at SundayScaries." Madeline Taylor POSTED ON January 13, 20...
-
A rare case of an intramedullary metastasis of a myxopapillary ependymoma Category: Unique Case Observations Article type: Case Report Autho...
-
https://sfakianakisorl.blogspot.com/2019/07/a-heavier-weight-at-birth-is-associated.html Alexandros Sfakianakis Anapafseos 5 . Agios Nikolao...
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου