Significance of polymethylmethacrylate (PMMA) modification by zinc oxide nanoparticles for fungal biofilm formation.

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Significance of polymethylmethacrylate (PMMA) modification by zinc oxide nanoparticles for fungal biofilm formation.

Int J Pharm. 2016 Jun 21;

Authors: Cierech M, Kolenda A, Grudniak AM, Wojnarowicz J, Woźniak B, Gołaś M, Swoboda-Kopeć E, Łojkowski W, Mierzwińska-Nastalska E

Abstract
The objective of this study was to obtain a material composite with antifungal properties for dentures to be used as an alternative protocol in denture stomatitis treatment and prevention. Denture stomatitis is still a clinical problem in patients particularly vulnerable to this disease. Composites of PMMA and doped ZnONPs (weight concentrations, 2.5%, 5%, 7.5%) and PMMA with sprayed solvothermal and hydrothermal ZnONPs were tested. The following investigations of newly formed biomaterials were undertaken: influence on Candida albicans solution, biofilm staining, XTT analysis and total amount of adhered Candida cells. These studies evidenced the antifungal activity of both nanocomposites PMMA- ZnONPs and the efficacy of sputtering of zinc oxide nanoparticles on the PMMA. The study of the biofilm deposition on the surface showed that antifungal properties increase with increasing concentration of ZnONPs. The XTT assay in conjunction with testing the turbidity of solutions may indicate the mechanism by which ZnONPs exert their effect on the increased induction of antioxidative stress in microorganism cells. The denture base made of the aforesaid materials may play a preventive role in patients susceptible to fungal infections. Based on the results obtained a modified treatment of stomatitis Type II (Newton's classification) complicated by fungal infection was proposed.

PMID: 27346417 [PubMed - as supplied by publisher]

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