In the present study, spray-dried nanoparticles-in-microparticles system (NiMS) of Acetazolamide (ACZ) was formulated for preparing orally disintegrating tablets (ODT). The objective behind the study was to investigate the effect of - concentration of chitosan (X<sub>1</sub>), volume of sodium tripolyphosphate (NaTPP) (X2) and inlet temperature of spray dryer (X<sub>3</sub>) on entrapment efficiency of ACZ using Central Composite Design (CCD). The spray dried optimized NiMS were formulated into orally disintegrating tablets using direct compression method. It was found that batch NiMS-7 (formulated using 0.5 % w/v chitosan; 20 ml NaTPP at inlet temperature of 140ºC) has a maximum entrapment efficiency 56.08% (w/w), loading capacity 68.39% (w/w), percentage yield 30.15%, (w/w) and particle size of 455 nm. Analysis of Variance (ANOVA) was applied on the entrapment efficiency of NiMS to study the fitting and the significance of the model. The estimated model may be further utilized as response surface for entrapment efficiency of NiMS. The batch NiMS-7 showed 90.70% drug release after three hours in phosphate buffer pH 7.4 and 61.52% in 0.1 N HCl. Infrared analysis of NiMS-7 showed no interaction between drug and polymer during the formulation process. The optimized batch was further formulated into ODT. The ODT was formulated using sodium starch glycolate (52.5 mg), microcrystalline cellulose (15 mg), lactose (34.5 mg), mannitol (15 mg), talc (1.50 mg) and magnesium stearate (1.50 mg). The formulated ODTs have a disintegration time of 38 seconds. The hardness, friability and weight variation of ODTs were found to be within pharmacopoeial limits. In vitro drug release studies revealed that cumulative percent of drug released was found to be 92.90% in 60 mins and the release data followed the first order kinetics. Therefore, this NiMS approach has been successfully applied to formulate ODT of ACZ and can be advantageous for the treatment of glaucoma in the case of paediatric patients.
http://ift.tt/2bXwMfn
http://ift.tt/2cQrMjc
Ιατρική : Τα αισθητικά συστήματα της όρασης,ακοής,αφής,γεύσης και όσφρησης.
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δημοφιλείς αναρτήσεις
-
Abstract Spontaneous spinal epidural hematoma (SSEH) very rarely develops in infants younger than 1 year old. To our knowledge, no previou...
-
Abstract Holistic processing is often considered to be limited to faces and non-face objects of expertise, with previous studies revealing...
-
Abstract Solitary fibrous tumors (SFTs) are relatively rare neoplasms that commonly occur in the pleura. The pathological feature of SFTs i...
-
Adipocytes orchestrate the formation of tertiary lymphoid organs in the creeping fat of Crohn's disease affected mesentery Publication d...
-
Correction to: Oliguria due to extensive subcapsular hematoma in renal graft: does surgical intervention ensure better outcomes? In the orig...
-
NAD(P)H: quinone oxidoreductase 1 (NQO1) is an antioxidant and detoxifying enzyme involved in the two-electron reduction of a wide variety o...
-
Introduction: A green analytical method simple, rapid and economic was validated for the determination of cefepime hydrochloride and has bee...
-
Skeletal muscle fibre swelling contributes to force depression in rats and humans: a mechanically-skinned fibre study Abstract This study in...
-
Abstract The presence of rare comorbidities in patients with cardiovascular disease (CVD) presents a diagnostic challenge to cardiologists...
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου