Is there a role of food additives in recurrent aphthous stomatitis? a prospective study with patch testing.

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Is there a role of food additives in recurrent aphthous stomatitis? a prospective study with patch testing.

Int J Dermatol. 2016 Dec 30;:

Authors: Gülseren D, Hapa A, Ersoy-Evans S, Elçin G, Karaduman A

Abstract
BACKGROUND: Recurrent aphthous stomatitis (RAS) is a common disease of the oral mucosa with an unknown etiology. This study aimed to determine if food additives play a role in the etiology of RAS as well as to determine if patch testing can be used to detect which allergens cause RAS.
METHODS: This prospective study included 24 patients with RAS and 22 healthy controls. All the participants underwent patch testing for 23 food additives.
RESULTS: In total, 21 (87.5%) RAS patients and 3 (13.6%) controls had positive patch test reactions to ≥1 allergens; the difference in the patch test positivity rate between groups was significant (P < 0.05). The most common allergen that elicited positive patch test results in the patient group was cochineal red (n = 15 [62.5%]), followed by azorubine (n = 11 [45.8%]) and amaranth (n = 6 [25%]).
CONCLUSIONS: The present findings show that food additives might play a role in the etiology of RAS and that patch testing could be a method for determining the etiology of RAS.

PMID: 28035659 [PubMed - as supplied by publisher]

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