A New Determinant of Poor Outcome after Spontaneous Subarachnoid Hemorrhage; Blood pH and the Disruption of Glossopharyngeal Nerve-Carotid Body Network: First Experimental Study.

A New Determinant of Poor Outcome after Spontaneous Subarachnoid Hemorrhage; Blood pH and the Disruption of Glossopharyngeal Nerve-Carotid Body Network: First Experimental Study.

World Neurosurg. 2017 Apr 26;:

Authors: Kanat A, Aydin MD, Bayram E, Kazdal H, Aydin N, Omeroglu M, Altinkaynak K, Kabalar ME, Yolas C, Ozturk C, Kepoglu U, Calik M

Abstract
OBJECTIVE: The chemoreceptor network, consisting of the glossopharyngeal nerve and carotid body (GPN-CB), is essential for the regulation of blood pH. Its ischemic insuts following subarachnoid hemorrhage (SAH)which may contribute to develop acidosis has not been investigated.
MATERIALS AND METHODS: Twent-three hybrid rabbits were used.They divided into three groups; Five (n=5) as control group, five (n=5) as SHAM group, the remaining 13 (n=13) as study group. 1cc serum saline, 1cc autolog arterial blood into the cisterna magna were injected; in SHAM and study group, respectively. Blood pH values of all annimals were recorded. After two weeks, animal were decapitated. The number of normal and degenerated neuron density ofCBs were counted by stereological methods,analysed statistically.
RESULTS: Two of 13 rabbits died within the second week. The mean blood pH values were measured as 7.35±0.07 in control, 7.33±0.06 in SHAM, 7.29±0.05 in rabbits with slight acidisis (n=6) and 7.23±0.02 in in rabbits with prominent acidosis. In control groups, the average normal neuronal density of the CB was 6432±790/mm(3) and degenerated neuron density was 11±3/mm(3) while the degenerated neuronal density in CB was 35±8/mm(3) in SHAM group, 1034±112/mm(3) in slight acidis developed group (n=6; p<0.05). Conversely, degenerated neuron density of CB was 2134±251/mm(3) in the prominent acidosis developed animals (n=8; p<0.005). Interestingly, in the dead rabbits, the degenerated neuron density of the carotid body was 3160±840/mm(3) CONCLUSION: Inverse relationship between neurodegeneration in the CB and PH values secondary to the disruption ofGPN-CBnetwork following SAH was foundwhich may contribute to develop acidosis.

PMID: 28456740 [PubMed - as supplied by publisher]

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