Relationship between iodine levels and papillary thyroid carcinoma: A systematic review and meta-analysis.

Relationship between iodine levels and papillary thyroid carcinoma: A systematic review and meta-analysis.

Head Neck. 2017 May 17;:

Authors: Lee JH, Hwang Y, Song RY, Yi JW, Yu HW, Kim SJ, Chai YJ, Choi JY, Lee KE, Park SK

Abstract
BACKGROUND: Iodine excess has been suggested as an exogenous risk factor of papillary thyroid cancer (PTC). We performed a systematic review and meta-analysis to assess the relationship between iodine exposure measured in various forms and PTC prevalence.
METHODS: We searched MEDLINE, Embase, and the Cochrane Library for case-control studies on iodine and PTC published up to December 2015. Exposure to iodine was compared between PTC and control groups.
RESULTS: From the 16 selected studies, the odds ratio (OR) for the overall effect size between high iodine exposure and PTC risk was 1.418 (95% confidence interval [CI] 1.054-1.909). Based on 7 studies conducted in high iodinated regions, a positive association between iodine exposure and PTC was observed (OR 2.200; 95% CI 1.389-3.483).
CONCLUSION: This study demonstrated a higher exposure to iodine in patients with PTC compared with controls, especially for patients from high iodinated regions.

PMID: 28513893 [PubMed - as supplied by publisher]

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