Vestibular Function in Adults With Epilepsy of Unknown Etiology.: Objective: This study aimed to evaluate vestibular function in adults with chronic epilepsy of unknown etiology in the inter-ictal period.
Background: Epilepsy is a chronic medical disorder. Life-long therapy may be required in one-third of patients. Epilepsy is associated with comorbid somatic conditions which impairs patients' quality of life.
Methods: This cross-sectional study included 28 with generalized tonic clonic (GTC) convulsions and 14 and 3 with temporal (TLE) and frontal lobe (FLE) epilepsies with secondary generalization (all were on regular carbamazepine therapy) and 40 healthy control subjects. The patients' mean age was 34.97 +/- 7.35 years and the duration of illness was 18.75 +/- 7.99 years. All underwent videonystagmography (VNG).
Results: Compared with controls, patients had frequent vestibular symptoms including dizziness (62.22%) (p = 0.0001) and sense of imbalance (44.44%) (p = 0.0001). Eleven patients (24.44%) had central vestibular dysfunction (p = 0.0001); 9 (20%) had mixed vestibular dysfunction and one (2.22%) had peripheral vestibular dysfunction (p = 0.0001). Abnormalities were observed in saccadic (44.4%) and pursuit (42.2%) eye movements, optokinetic nystagmus (42.2%) and positioning/positional (11.11%) and caloric (13.33%) testing. TLE and FLE were associated with more VNG abnormalities than GTC. No significant differences were observed in the demographic and clinical characteristics between patients with and without VNG abnormalities.
Conclusion: Vestibular manifestations are frequent in patients with epilepsy. This may be a result of the permanent damaging effect of chronic epilepsy on the vestibular cortical areas and/or a toxic effect from prolonged carbamazepine therapy on the peripheral and central vestibular systems.
Copyright (C) 2017 by Otology & Neurotology, Inc. Image copyright (C) 2010 Wolters Kluwer Health/Anatomical Chart Company
http://ift.tt/2tBvxvF
Ιατρική : Τα αισθητικά συστήματα της όρασης,ακοής,αφής,γεύσης και όσφρησης.
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δημοφιλείς αναρτήσεις
-
Publication date: April 2017 Source: European Journal of Vascular and Endovascular Surgery, Volume 53, Issue 4 http://ift.tt/2oUTFL8 ...
-
Related Articles Identification of somatic TERT promoter mutations in familial non-medullary thyroid carcinomas (FNMTC). Clin Endocri...
-
Correlation Between the Epworth Sleepiness Scale and the Maintenance of Wakefulness Test in Patients With Narcolepsy Participating in Two Cl...
-
The Role of KIT Mutations in Anaphylaxis Abstract Purpose of Review Gain of function KIT mutations are detected in clonal mast cell diseases...
-
AbstractBackground Little is known about patterns of medication use and lifestyle counseling in patients with peripheral artery disease (PA...
-
# Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174, alsfakia@gmail.com , T...
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου