Mitochondrial dysfunction induced by mitochondria-related [beta]-amyloid (A[beta]) accumulation

Frontal cortical mitochondrial dysfunction and mitochondria-related [beta]-amyloid accumulation by chronic sleep restriction in mice.: Mitochondrial dysfunction induced by mitochondria-related [beta]-amyloid (A[beta]) accumulation is increasingly being considered a novel risk factor for sporadic Alzheimer's disease pathophysiology. The close relationship between chronic sleep restriction (CSR) and cortical A[beta] elevation was confirmed recently. By assessing frontal cortical mitochondrial function (electron microscopy manifestation, cytochrome C oxidase concentration, ATP level, and mitochondrial membrane potential) and the levels of mitochondria-related A[beta] in 9-month-old adult male C57BL/6J mice subjected to CSR and as an environmental control (CO) group, we aimed to evaluate the association of CSR with mitochondrial dysfunction and mitochondria-related A[beta] accumulation. In this study, frontal cortical mitochondrial dysfunction was significantly more severe in CSR mice compared with CO animals. Furthermore, CSR mice showed higher mitochondria-associated A[beta], total A[beta], and mitochondria-related [beta]-amyloid protein precursor (A[beta]PP) levels compared with CO mice. In the CSR model, mouse frontal cortical mitochondrial dysfunction was correlated with mitochondria-associated A[beta] and mitochondria-related A[beta]PP levels. However, frontal cortical mitochondria-associated A[beta] levels showed no significant association with cortical total A[beta] and mitochondrial A[beta]PP concentrations. These findings indicated that CSR-induced frontal cortical mitochondrial dysfunction and mitochondria-related A[beta] accumulation, which was closely related to mitochondrial dysfunction under CSR.

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