Surgical Treatment of Medullary Thyroid Cancer
Recent Results Cancer Res.
Authors: Machens A, Dralle H
Abstract
Medullary thyroid cancer (MTC) can vary in tumor biology and progression. The most important indicator of distant metastases, determining clinical outcome, is lymph node metastasis to the neck and mediastinum. Surgical cure is within reach in node-negative tumors or node-positive tumors with fewer than 10 lymph node metastases. From a surgical point of view, compartment-oriented lymph node dissection, clearing gross, and occult metastases are important for locoregional tumor control. The discovery of missense germline mutations in the RET proto-oncogene and the close genotype-phenotype correlation in hereditary MTC promoted the worldwide breakthrough of prophylactic thyroidectomy. The best approach to hereditary MTC affords the DNA-based/biochemical concept, which is geared at limiting prophylactic surgery to total thyroidectomy at minimal surgical morbidity before the tumor can spread beyond the thyroid capsule. To improve outcome, routine calcitonin screening in nodular thyroid disease and DNA-based screening of the offspring in RET families are effective interventions.
PMID: 26494390 [PubMed - indexed for MEDLINE]
http://ift.tt/29BAjRk
Ιατρική : Τα αισθητικά συστήματα της όρασης,ακοής,αφής,γεύσης και όσφρησης.
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δημοφιλείς αναρτήσεις
-
Your subscribed feeds are not being updated automatically because this setting is turned off. Turn on automatic feed updates You...
-
Pediatric Drugs Vancomycin Use in a Paediatric Intensive Care Unit of a Tertiary Care Hospital Abstract Background Vancomycin is one of the ...
-
British Journal of Oral and Maxillofacial Surgery... Stem Cells and DevelopmentMesenchymal Stem/Stroma... [ASAP] Self-Assembly of Giant Mo...
-
Journals 1a17kr-s25tv.htmlAllergy_Immunology Update from NEJM.org.eml 2az5g2-skieq.htmlAeolian Research _ Volume 42.eml 3a4c5r-hewxc.htmlAct...
-
Abstract The existing literature suggests two standpoints in defining heat intolerance, which are heat tolerance as state or trait. The fo...
-
Talon cusp on palatally erupted mesiodens : Ashalata Gannepalli, Bhargavi Krishna Ayinampudi, Shilpa Perkari, Amruta Appala, Sanjay Reddy Po...
-
SAGE Publications Inc: Technology in Cancer Rese... Latest Results for PsychopharmacologyConscious p... NEJM : ResearchRandomized Trial o...
-
Publication date: July 2016 Source: American Journal of Orthodontics and Dentofacial Orthopedics, Volume 150, Issue 1 Author(s): Nikolaos ...
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου