Publication date: August 2016
Source:Annals of Allergy, Asthma & Immunology, Volume 117, Issue 2
Author(s): Monica G. Lawrence, John W. Steinke, Larry Borish
ObjectiveTo discuss the general immunologic changes that occur during immunotherapy, focusing on the differences between subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT).Data SourcesPubMed literature review.Study SelectionsArticles pertaining to SCIT and SLIT, with specific emphasis on those that included immune mechanistic studies.ResultsBoth SCIT and SLIT are characterized by the induction of regulatory B and T cells, decreased allergen-specific T-cell proliferation, a shift from a TH2 to TH1 cytokine milieu and from an IgE to an IgG4/IgA antibody response. These changes are accompanied by clinical improvement in symptoms.ConclusionImmunotherapy using allergen extracts administered via both subcutaneous and sublingual approaches have demonstrated efficacy in the treatment of allergic rhinoconjunctivitis and other allergic conditions. There are subtle differences between the approaches, and understanding these differences may help clinicians select a preferred route of therapy for particular patients or allergens, depending on the immune response that is being targeted.
Source:Annals of Allergy, Asthma & Immunology, Volume 117, Issue 2
Author(s): Monica G. Lawrence, John W. Steinke, Larry Borish
ObjectiveTo discuss the general immunologic changes that occur during immunotherapy, focusing on the differences between subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT).Data SourcesPubMed literature review.Study SelectionsArticles pertaining to SCIT and SLIT, with specific emphasis on those that included immune mechanistic studies.ResultsBoth SCIT and SLIT are characterized by the induction of regulatory B and T cells, decreased allergen-specific T-cell proliferation, a shift from a TH2 to TH1 cytokine milieu and from an IgE to an IgG4/IgA antibody response. These changes are accompanied by clinical improvement in symptoms.ConclusionImmunotherapy using allergen extracts administered via both subcutaneous and sublingual approaches have demonstrated efficacy in the treatment of allergic rhinoconjunctivitis and other allergic conditions. There are subtle differences between the approaches, and understanding these differences may help clinicians select a preferred route of therapy for particular patients or allergens, depending on the immune response that is being targeted.
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