Left atrial ablation strategies are being increasingly performed as a Class 1 therapeutic indication for drug refractory paroxysmal atrial fibrillation (AF). Traditionally AF ablation has been performed with patients on uninterrupted warfarin therapy, however over the last few years, novel oral anticoagulants (NOACs) have emerged as attractive alternatives to warfarin in order to reduce stroke risk due to AF. NOACs are therefore increasingly being used instead of warfarin in the management of AF. There is also mounting evidence mainly in the form of small randomised studies and meta-analysis that have demonstrated that the use of NOACs for AF ablation is efficacious, safe and convenient. However the peri-procedural dosing protocols used in various studies especially in terms of whether NOAC use is interrupted or uninterrupted during AF ablation, have significant inter-operator and inter-institution variability. Currently there is also a lack of randomised controlled trials to validate the data obtained from meta-analyses. There is also evidence that use of NOACs may increase the requirement of unfractionated heparin during the procedure. This review article shall examine the currently available evidence-base, appraise the gaps in the current evidence and also underscore the need for larger randomised clinical trials in this rapidly developing field.
http://ift.tt/2bOH6Xl
http://ift.tt/2bRfdRl
Ιατρική : Τα αισθητικά συστήματα της όρασης,ακοής,αφής,γεύσης και όσφρησης.
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δημοφιλείς αναρτήσεις
-
Evaluation of the effect of three mouthwashes on the mechanical properties and surface morphology of several orthodontic wires: An in vitro ...
-
Thyroid hormone level is associated with the frequency and severity of acute transverse myelitis. : Acute transverse myelitis (ATM) is a pro...
-
AtmosphereAtmosphere, Vol. 11, Pages 932: Last ... The New England Journal of Medicine: Cancer, Ge... Analytical Chemistry[ASAP] Cel...
-
Abstract Background Drug-related problems are mostly preventable or predictable circumstances that may impact on health outcomes. Clinica...
-
Alternative Techniques in Özgür Sürmelioğlu 1 , Süleyman Özdemir 1 , Özgür Tarkan 1 , Ülkü Tuncer 1 , Fikret Çet...
-
Cancers, Vol. 9, Pages 92: Regional Delivery of Chimeric Antigen Receptor (CAR) T-Cells for Cancer Therapy : Cancers, Vol. 9, Pages 92: Re...
-
Abstract Objectives The aim of this systematic review was to determine whether soft tissue biotype at implant placement has an influenc...
-
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182, A case of occult bilateral optic nerve...
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου