Publication date: Available online 15 September 2016
Source:Autoimmunity Reviews
Author(s): Tanima Bose, Maria Diedrichs-Moehring, Gerhild Wildner
Understanding the immunopathogenesis of autoimmune and inflammatory diseases is a prerequisite for specific and effective therapeutical intervention. This review focuses on animal models of two common ocular inflammatory diseases, dry eye disease (DED), affecting the ocular surface, and uveitis with inflammation of the inner eye. In both diseases autoimmunity plays an important role, in idiopathic uveitis immune reactivity to intraocular autoantigens is pivotal, while in dry eye disease autoimmunity seems to play a role in one subtype of disease, Sjögren's syndrome (SjS). Comparing the immune mechanisms underlying both eye diseases reveals similarities, and significant differences. Studies have shown genetic predispositions, T and B cell involvement, cytokine and chemokine signatures and signaling pathways as well as environmental influences in both DED and uveitis. Uveitis and DED are heterogeneous diseases and there is no single animal model, which adequately represents both diseases. However, there is evidence to suggest that certain T cell-targeting therapies can be used to treat both, dry eye disease and uveitis. Animal models are essential to autoimmunity research, from the basic understanding of immune mechanisms to the pre-clinical testing of potential new therapies.
http://ift.tt/2cO16yB
http://ift.tt/2ciGCvr
Ιατρική : Τα αισθητικά συστήματα της όρασης,ακοής,αφής,γεύσης και όσφρησης.
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δημοφιλείς αναρτήσεις
-
Summary Background Hand eczema is more common in healthcare workers compared to the general population. The hands are subject to changin...
-
Abstract Dissolution is an important property that influences nanoparticle abundance and biological responses, and often becomes a critica...
-
Abstract Background Infants with acute lymphoblastic leukemia (ALL) treated with high-dose methotrexate may have reduced methotrexate cl...
-
The post Why We Avoid Mercury Fillings – We Use Safe Composite Resin Fillings To Match Your Tooth Colour appeared first on Family Dentistry...
-
Consent and Autonomy in the Genomics Era Abstract Purpose of Review Genomic tests offer increased opportunity for diagnosis, but their outpu...
-
COMPLICATIONS ASSOCIATED WITH SUPRAGLOTTIC AIRWAY USE IN AN URBAN AMBULANCE SERVICE: A CASE SERIES : Background Current resuscitation guid...
-
Publication date: June 2017 Source: Clinical Therapeutics, Volume 39, Issue 6 http://ift.tt/2tFQtkS http://ift.tt/2sHVf46
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου