Histomorphometric characterization of subgemmal neurogenous plaques

Publication date: Available online 9 January 2017
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Author(s): Ana Carolina Amorim Pellicioli, Felipe Paiva Fonseca, Rodrigo Neves Silva, Luiz Alcino Monteiro Gueiros, Oslei Paes de Almeida, Pablo Agustin Vargas, Marcio Ajudarte Lopes, Helder Antonio Rebelo Pontes, Manoela Domingues Martins, Vinícius Coelho Carrard, Alan Roger dos Santos Silva
ObjectivesCharacterize the histomorphometric features of subgemmal neurogenous plaques (SNPs) to better understand their relationship to surrounding microanatomy included in within the tissue biopsy samples of the tongue.Study designA 12-year retrospective study on the files of 3 oral pathology centers retrieved 28 cases of SNPs. Hematoxylin and eosin stained sections were used to histological analysis, whereas immunohistochemical staining for S100 protein was performed to better characterize the neural structures. Slides were scanned and histomorphometric analysis carried out using ImageScope software.ResultsTwenty-one women (75%) and seven (21.4%) men comprised the sample with a mean age of 46.4 and 49 years, respectively. According to the morphological characterization, 20 (71,4%) cases were juxtaposed to the tongue epithelium and 16 (57,1%) cases were associated with lymphoid tissue. The mean area of the SNPs was 0.160 mm² and the mean distance to the overlying epithelium was 0.311 mm.ConclusionSNPs are normal neural structures located on the posterior border of the tongue that represent a non-neoplastic regional anatomical variation. In some cases, signs or symptoms might be present and further investigation should be performed. Pathologists should be aware of this entity to avoid misdiagnosis with neural lesions.



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