Persistent, Immunosuppression, Inflammation, Catabolism Syndrome and Diaphragmatic Dysfunction

Abstract

Purpose of review

The purpose of this review is to explore the relationship between ICU-acquired weakness, diaphragm dysfunction, and persistent immunosuppression, inflammation, catabolism syndrome (PICS), as well as if there are any therapies that can help rehabilitate these patients.

Recent findings

Literature pertaining to PICS is scant, as it is a relatively new description of encompassing chronic multiorgan dysfunction and chronic critical illness. PICS patients invariably have persistent diaphragm dysfunction and ICU-acquired weakness. To better understand how severe each state is and how they are related, the literature was reviewed.

Summary

Combating diaphragm dysfunction, ICU-acquired weakness, and PICS is a difficult task for intensivists. There are certain nutritional supplements that can help rehabilitate these patients, but there is no silver bullet right now. Helping these patients currently takes a multimodal approach.

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