- Abstract
- Objectives
- Periostin is a matricellular protein, synthesized in the airway epithelium and induced by interleukin (IL)-4 and IL-13. The significance of periostin as a biomarker of T helper type 2 cell (Th2)-induced airway inflammation, and as a measure of the response to Th2-targeted therapy, has recently been highlighted. We explored the relationship between serum periostin and allergic rhinitis in Korean children.
- Methods
- Data for fifth and sixth grade children from six randomly selected elementary schools located in Jeju and Seogwipo City, Korea, were investigated. Serum periostin levels were determined by enzyme-linked immunosorbent assay. Sex, school grade, body mass index, and presence of allergic nasal symptoms were obtained via a self-reported survey and skin prick testing was performed.
- Results
- There were no significant differences between groups, when stratification was applied according to sex, grade, presence of atopy, and presence of allergic nasal symptoms. Sex and body mass index were significantly associated with serum periostin levels in multivariate linear regression analysis. However, allergic rhinitis was not associated with serum periostin levels.
- Conclusion
- Allergic rhinitis or allergic sensitization in Korean children did not influence serum periostin levels. Further studies are required to investigate the significance of serum periostin levels in pediatric allergic rhinitis.
- Keywords
- Periostin; Allergic rhinitis; Allergic sensitization; Children; Korean
- Corresponding author. Department of Otorhinolaryngology, Jeju National University Hospital, 102 Jejudaehakno, Jeju, 63243, South Korea.
- 1
- Both authors contributed equally to this work.
- © 2016 Elsevier Ireland Ltd. All rights reserved.
- Original Research Article
- Pages 24-29
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