Fatal invasive aspergillosis caused by Aspergillus niger after bilateral lung transplantation

Publication date: Available online 18 May 2017
Source:Medical Mycology Case Reports
Author(s): Enora Atchade, Sylvain Jean-Baptiste, Sandrine Houze, Claire Chabut, Laurent Massias, Yves Castier, Olivier Brugière, Hervé Mal, Philippe Montravers
Aspergillus niger is usually considered to be a low virulence fungus, not commonly reported to cause invasive infections. Invasive pulmonary aspergillosis due to Aspergillus niger was diagnosed in a 43-year-old woman following bilateral lung transplantation. Intravenous voriconazole failed to control progression of the disease. Despite salvage therapy with a combination of voriconazole and caspofungin for 23 days, the patient developed massive hemoptysis leading to death. The authors report the clinical features and treatment of this case.



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