Detection of trace concentrations of S-nitrosothiols by means of a capacitive sensor.

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Detection of trace concentrations of S-nitrosothiols by means of a capacitive sensor.

PLoS One. 2017;12(10):e0187149

Authors: Seckler JM, Meyer NM, Burton ST, Bates JN, Gaston B, Lewis SJ

Abstract
Small molecule S-nitrosothiols are a class of endogenous chemicals in the body, which have been implicated in a variety of biological functions. However, the labile nature of NO and the limits of current detection assays have made studying these molecules difficult. Here we present a method for detecting trace concentrations of S-nitrosothiols in biological fluids. Capacitive sensors when coupled to a semiconducting material represent a method for detecting trace quantities of a chemical in complex solutions. We have taken advantage of the semiconducting and chemical properties of polydopamine to construct a capacitive sensor and associated method of use, which specifically senses S-nitrosothiols in complex biological solutions.

PMID: 29073241 [PubMed - in process]

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