Cyclophosphamide Induced Disruptions to Appetitive Qualities and Detection Thresholds of NaCl: Comparison of single dose and dose fractionation effects.
Chem Senses. 2018 May 19;:
Authors: Jewkes BC, Gomella MG, Lowry ET, Benner JA, Delay ER
Abstract
Chemotherapy is one of the most common treatments for cancer, however a side effect is often altered taste. This study examined how cyclophosphamide, a chemotherapy drug, affects salt taste in mice. Based on previous findings, it was predicted that cyclophosphamide-induced disruptions in salt taste would be observed near days 2-4, 8-12, and 22-24 days post treatment, and that multiple, smaller doses would cause more severe disruptions to taste. To test these predictions, two experiments were performed, one using brief access testing to measure appetitive qualities, and another using operant conditioning to measure detection thresholds. After a single 100 mg/kg cyclophosphamide injection, peak alterations in brief access lick rates were seen near days 5-8 and 15 post treatment, whereas peak alterations in detection thresholds were seen 6, 14 and 20 days post treatment. After five 20 mg/kg injections of cyclophosphamide, brief access lick rates revealed disruptions only on post injection day 8 whereas thresholds appeared to cycle, gradually increased to and decreased from peak elevations on post treatment days 4, 10, 15, 20, and 23. While salt taste functions were disrupted by cyclophosphamide, the patterns of these disruptions were less severe and shorter than expected from cell morphology studies, suggesting a functional adjustment to maintain behavioral accuracy. Fractionation of cyclophosphamide dosing had minimum effect on brief access responses but caused longer, cyclic-like disruptions of detection thresholds compared to single dose administration.
PMID: 29788185 [PubMed - as supplied by publisher]
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