Spatial and Temporal Discretization in Cardiac Electrophysiology

xloma.fota13 shared this article with you from Inoreader A Numerical Study on the Effects of Spatial and Temporal Discretization in Cardiac Electrophysiology Via International Journal for Numerical Methods in Biomedical Engineering Summary Millions of degrees of freedom are often required to accurately represent the electrophysiology of the myocardium due to the presence of discretization effects. This study seeks to explore the influence of temporal and spatial discretization on the simulation of cardiac electrophysiology in conjunction with changes in modelling choices. Several finite element analyses are performed to examine how discretization affects solution time, conduction velocity and electrical excitation. Discretization effects are considered along with changes in the electrophysiology model and solution approach. Two action potentialmodels are considered: the Aliev‐Panfilovmodel and the ten Tusscher‐Noble‐Noble‐Panfilovmodel. The solution approaches consist of two time integration schemes and different treatments for solving the local system of ordinary differential equations. The efficiency and stability of the calculation approaches are demonstrated to be dependent on the action potential model. The dependency of the conduction velocity on the element size and time step is shown to be different for changes inmaterial parameters. Finally, the discrepancies between the wave propagation in coarse and fine meshes are analysed based on the temporal evolution of the transmembrane potential at a node and its neighbouring Gauss points. Insight obtained from this study can be used to suggest new methods to improve the efficiency of simulations in cardiac electrophysiology. This article is protected by copyright. All rights reserved. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.