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Gain The Upperhand-More Political Influence For ASBA Members
Today, 28 Ιουνίου 2016, 1 hour ago | Αλέξανδρος Σφακιανάκης
There is no doubt that the Presidential election has been on the forefront of political news this year. The latest on the subject mentioned by multiple media outlets surround the possibility of Former Arizona Governor Jan Brewer joining Donald Trump's national ticket as the vice-presidential pick. So where is the connection to members of the American Sleep and Breathing Academy (ASBA)? David Gergen, Executive Director of the ASBA, has remained close friends with Jan Brewer and the family for decades including the duration of her six year service to Arizona. This adds to the already vast reach the ASBA has in the political world and provides an additional valuable connection for ASBA members.
Gergen hosted the largest sleep apnea awareness event in January which attracted not only 3,000 attendees, but future Hall of Fame Larry Fitzgerald, Phoenix Police Department and Gergen's high school friend Arizona Attorney General Mark Brnovich. Subsequently, Mr. Brnovich was treated for obstructive sleep apnea (OSA) by ASBA Diplomate Dr. Castle at Koala Sleep Center of Arrowhead.
The ASBA has long held strong footing associated with congress and the US Department of Transportation. This has clearly been shown by current involvement in the process of establishing protocol for the transportation industry to be treated exclusively by ASBA members; David Gergen commissioned Dr. Elliott Alpher, ASBA Diplomate, earlier this year to launch an initiative in collaboration with Congresswoman Anna G. Eshoo to make oral appliance therapy the benchmark treatment for OSA.
As a result, a special committee of ASBA Diplomates and other powerful figures such as NFL greats Roy Green, Eric Dickerson, Marcus Allen, Congressman Marty Russo, Congressman Jim McGovern, Congresswoman Anna Eshoo, and Senator Chris Dodd will be sent back to Washington to speak to the Senate on September 27, 2016.
Dr. Elliott Alpher says, "The ASBA is the only academy fighting for the dentists' rights in the sleep apnea arena and the efforts will become stronger as the American Sleep and Breathing Academy grows. The more members we have the more firepower we'll have. I am so pleased that I have joined this academy because this is the only academy making a huge difference in my humble opinion. We are so blessed to have so many congressmen and congresswomen as well as NFL legends backing us."
When considering the political/NFL ties the American Sleep and Breathing Academy holds, value in being a member and advantages over non-members certainly become apparent.
Learn more about becoming a member/diplomate of the ASBA at Americansleepandbreathingacademy.com or call 602-478-9713
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Gergen hosted the largest sleep apnea awareness event in January which attracted not only 3,000 attendees, but future Hall of Fame Larry Fitzgerald, Phoenix Police Department and Gergen's high school friend Arizona Attorney General Mark Brnovich. Subsequently, Mr. Brnovich was treated for obstructive sleep apnea (OSA) by ASBA Diplomate Dr. Castle at Koala Sleep Center of Arrowhead.
The ASBA has long held strong footing associated with congress and the US Department of Transportation. This has clearly been shown by current involvement in the process of establishing protocol for the transportation industry to be treated exclusively by ASBA members; David Gergen commissioned Dr. Elliott Alpher, ASBA Diplomate, earlier this year to launch an initiative in collaboration with Congresswoman Anna G. Eshoo to make oral appliance therapy the benchmark treatment for OSA.
As a result, a special committee of ASBA Diplomates and other powerful figures such as NFL greats Roy Green, Eric Dickerson, Marcus Allen, Congressman Marty Russo, Congressman Jim McGovern, Congresswoman Anna Eshoo, and Senator Chris Dodd will be sent back to Washington to speak to the Senate on September 27, 2016.
Dr. Elliott Alpher says, "The ASBA is the only academy fighting for the dentists' rights in the sleep apnea arena and the efforts will become stronger as the American Sleep and Breathing Academy grows. The more members we have the more firepower we'll have. I am so pleased that I have joined this academy because this is the only academy making a huge difference in my humble opinion. We are so blessed to have so many congressmen and congresswomen as well as NFL legends backing us."
When considering the political/NFL ties the American Sleep and Breathing Academy holds, value in being a member and advantages over non-members certainly become apparent.
Learn more about becoming a member/diplomate of the ASBA at Americansleepandbreathingacademy.com or call 602-478-9713
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Mistuning detection performance of ferrets in a go/no-go task
Yesterday, 27 Ιουνίου 2016, 7:58:16 μμ | Αλέξανδρος Σφακιανάκης
The harmonic structure of sounds is an important grouping cue in auditory scene analysis. The ability of ferrets to detect mistuned harmonics was measured using a go/no-go task paradigm. Psychometric functions plotting sensitivity as a function of degree of mistuning were used to evaluate behavioral performance using signal detection theory. The mean (± standard error of the mean) threshold for mistuning detection was 0.8 ± 0.1 Hz, with sensitivity indices and reaction times depending on the degree of mistuning. These data provide a basis for investigation of the neural basis for the perception of complex sounds in ferrets, an increasingly used animal model in auditory research.
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Integration of partial information for spoken and written sentence recognition by older listeners
Yesterday, 27 Ιουνίου 2016, 7:58:16 μμ | Αλέξανδρος Σφακιανάκης
Older adults have difficulty understanding speech in challenging listening environments. Combining multisensory signals may facilitate speech recognition. This study measured recognition of interrupted spoken and written sentences by older adults for different preserved stimulus proportions. Unimodal performance was first examined when only interrupted text or speech stimuli were presented. Multimodal performance with concurrently presented text and speech stimuli was tested with delayed and simultaneous participant responses. Older listeners performed better in unimodal speech-only compared to text-only conditions across all proportions preserved. Performance was also better in delayed multimodal conditions. Comparison to a younger sample suggests age-related amodal processing declines.
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Is markerless acquisition technique adequate for speech production?
Yesterday, 27 Ιουνίου 2016, 7:58:16 μμ | Αλέξανδρος Σφακιανάκης
In this study, the precision of markerless acquisition techniques have been assessed when used to acquire articulatory data for speech production studies. Two different markerless systems have been evaluated and compared to a marker-based one. The main finding is that both markerless systems provide a reasonable result during normal speech and the quality is uneven during fast articulated speech. The quality of the data is dependent on the temporal resolution of the markerless system.
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The effect of nocturnal wear of dentures on the sleep quality: a systematic review and meta-analysis
Yesterday, 27 Ιουνίου 2016, 7:58:16 μμ | Αλέξανδρος Σφακιανάκης
Abstract
Purpose
The effect of nocturnal wear of denture on sleep quality and integrity is still not well understood. Therefore, this systematic review was conducted to provide evidence on this topic.Methods
Electronic searches were conducted from 1964 up to September 2015, using MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials. Only publications in English or French, in which sleep quality of edentate adult individuals wearing dentures at night was compared to those not wearing were included in the review. Random effects models were used to pool the effect sizes.Results
A total of 10 studies were included in the systematic review and 5 in the meta-analysis. No statistically significant difference between sleeping with denture and without denture was found for the Apnea-Hypopnea Index (AHI; Standard Mean Difference = −0.60, 95 % CI −1.67–0.47; Z = −1.10; p = 0.27). However, there was considerable heterogeneity in the studies included in the meta-analysis (Tau2 = 1.34; Q-value = 59.32, df = 4 (P < 0.0001); I2 = 93.3 %). When results from randomized controlled trials (RCTs) were pooled in subgroup analyses of AHI, there was a tendency towards favoring sleeping without dentures (P = 0.059) and no evidence of heterogeneity between studies (Tau2 = 0.000; Q-value = 0.06, df = 1 (P = 0.80); I2 = 0.000 %).Conclusion
The current evidence suggests that there is no difference in the sleep quality and integrity of individuals wearing or not wearing their denture during sleep. However, the results of randomized controlled trials favoring sleeping without dentures and the likely presence of bias in the previous studies indicate the need for further randomized controlled trials for the development of clinical guideline.from #SleepMedicine via xlomafota13 on Inoreader http://ift.tt/28YItlJ
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Endothelial function and carotid intima media thickness in obstructive sleep apnea without comorbidity
Yesterday, 27 Ιουνίου 2016, 7:58:16 μμ | Αλέξανδρος Σφακιανάκης
Abstract
Purpose
The objective of this study was to evaluate endothelial function and carotid intima media thickness (CIMT) in moderate to severe obstructive sleep apnea (OSA) without comorbidities.Methods
It is an observational case control study in which endothelial function was assessed using flow-mediated dilatation (FMD) and peripheral arterial tonometry (PAT), and carotid artery ultrasound was used to measure CIMT in study group subjects that included 20 normotensive, non-diabetic, treatment naïve, and moderate to severe OSA patients, and 20 normotensive, non-diabetic, and non-OSA subjects served as a control group. Study was conducted in Polysomnography Laboratory, Department of Internal Medicine, All India Institute of Medical Sciences (AIIMS) Hospital, New Delhi.Results
FMD was significantly lower in the moderate to severe OSA group compared to non-OSA group (mean ± SD, 8.3 ± 2.8 vs. 13.4 ± 4.1 %; p = 0.0001). Reactive hyperemia index (RHI) was also significantly lower in the OSA group (1.55 ± 0.27 vs. 2.01 ± 0.48, p = 0.0007). CIMT was observed to be significantly higher in the OSA group compared to the non-OSA group (0.54 ± 0.09 vs. 0.48 ± 0.08 mm; p = 0.049). In the OSA group, FMD, RHI, and CIMT did not show a significant correlation with OSA disease severity indices [apnea hypopnea index (AHI), oxygen desaturation index (ODI), and minimum O2 saturation].Conclusion
Endothelial function in macrovascular and microvascular circulation is significantly impaired in moderate to severe OSA patients without comorbidities. These patients also show evidence of subclinical atherosclerosis, in the form of increased CIMT.from #SleepMedicine via xlomafota13 on Inoreader http://ift.tt/28Y2tZ8
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Uses of Various Grafting Techniques in External Approach Rhinoplasty: An Overview
Yesterday, 27 Ιουνίου 2016, 7:27:53 μμ | Αλέξανδρος Σφακιανάκης
Abstract
The surgeons performing rhinoplasty found Graft selection the greatest challenge. To avoid an immune response the preferred choice thus far for nasal reconstruction would be autograft compared to allograft due to its lower rate of rejection. We have evaluated 30 patients who underwent open rhinoplasty and We used conchal and septal cartilaginous grafts in various forms by the open approach to correct various nasal deformities compared our experience regarding the operative technique, graft availability, indications, and limitations. No bony graft material or synthetic materials were used. Preoperative extensive evaluation of the patient was done in order to determine the type of deformity and the type of graft to be used in order to correct the deformity. Preoperative and postoperative photographs were taken in four basic views: frontal, lateral, lateral-oblique and basal in order to assess the results of the surgery. The study was done on 30 patients (20 male and 10 females) using the external rhinoplasty approach using the septal and conchal cartilages in different forms. Autologous septal cartilage was used in most of the patients (25 out of 30) and conchal cartilage was used in 5 patients. Multiple grafting techniques were used in some patients. Three patients had traumatic etiology. Columellar strut graft along with TIG technique was used in 16 patients, spreader graft was used in 8 patients, and septal extension graft was used in 5 patient and shield graft in 1 patient. Septorhinoplasty continues to evolve through various new techniques and modifications with the main goal to improve functional nasal airway and to restore cosmetic harmony to the face. Optimum result is very much dependent on the surgeon's attention to functional, aesthetic, and reconstructive principles and graft selection.from #ORL via xlomafota13 on Inoreader http://ift.tt/28YCTj6
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Uses of Various Grafting Techniques in External Approach Rhinoplasty: An Overview
Yesterday, 27 Ιουνίου 2016, 7:27:53 μμ | Αλέξανδρος Σφακιανάκης
Abstract
The surgeons performing rhinoplasty found Graft selection the greatest challenge. To avoid an immune response the preferred choice thus far for nasal reconstruction would be autograft compared to allograft due to its lower rate of rejection. We have evaluated 30 patients who underwent open rhinoplasty and We used conchal and septal cartilaginous grafts in various forms by the open approach to correct various nasal deformities compared our experience regarding the operative technique, graft availability, indications, and limitations. No bony graft material or synthetic materials were used. Preoperative extensive evaluation of the patient was done in order to determine the type of deformity and the type of graft to be used in order to correct the deformity. Preoperative and postoperative photographs were taken in four basic views: frontal, lateral, lateral-oblique and basal in order to assess the results of the surgery. The study was done on 30 patients (20 male and 10 females) using the external rhinoplasty approach using the septal and conchal cartilages in different forms. Autologous septal cartilage was used in most of the patients (25 out of 30) and conchal cartilage was used in 5 patients. Multiple grafting techniques were used in some patients. Three patients had traumatic etiology. Columellar strut graft along with TIG technique was used in 16 patients, spreader graft was used in 8 patients, and septal extension graft was used in 5 patient and shield graft in 1 patient. Septorhinoplasty continues to evolve through various new techniques and modifications with the main goal to improve functional nasal airway and to restore cosmetic harmony to the face. Optimum result is very much dependent on the surgeon's attention to functional, aesthetic, and reconstructive principles and graft selection.from #ORL via xlomafota13 on Inoreader http://ift.tt/28YCTj6
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The acoustic power of a vibrating clamped circular plate revisited in the wide low frequency range using expansion into the radial polynomials
Yesterday, 27 Ιουνίου 2016, 6:57:18 μμ | Αλέξανδρος Σφακιανάκης
This study deals with the classical problem of sound radiation of an excited clamped circular plate embedded into a flat rigid baffle. The system of the two coupled differential equations is solved, one for the excited and damped vibrations of the plate and the other one—the Helmholtz equation. An approach using the expansion into radial polynomials leads to results for the modal impedance coefficients useful for a comprehensive numerical analysis of sound radiation. The results obtained are accurate and efficient in a wide low frequency range and can easily be adopted for a simply supported circular plate. The fluid loading is included providing accurate results in resonance.
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Mistuning detection performance of ferrets in a go/no-go task
Yesterday, 27 Ιουνίου 2016, 6:57:18 μμ | Αλέξανδρος Σφακιανάκης
The harmonic structure of sounds is an important grouping cue in auditory scene analysis. The ability of ferrets to detect mistuned harmonics was measured using a go/no-go task paradigm. Psychometric functions plotting sensitivity as a function of degree of mistuning were used to evaluate behavioral performance using signal detection theory. The mean (± standard error of the mean) threshold for mistuning detection was 0.8 ± 0.1 Hz, with sensitivity indices and reaction times depending on the degree of mistuning. These data provide a basis for investigation of the neural basis for the perception of complex sounds in ferrets, an increasingly used animal model in auditory research.
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Integration of partial information for spoken and written sentence recognition by older listeners
Yesterday, 27 Ιουνίου 2016, 6:57:18 μμ | Αλέξανδρος Σφακιανάκης
Older adults have difficulty understanding speech in challenging listening environments. Combining multisensory signals may facilitate speech recognition. This study measured recognition of interrupted spoken and written sentences by older adults for different preserved stimulus proportions. Unimodal performance was first examined when only interrupted text or speech stimuli were presented. Multimodal performance with concurrently presented text and speech stimuli was tested with delayed and simultaneous participant responses. Older listeners performed better in unimodal speech-only compared to text-only conditions across all proportions preserved. Performance was also better in delayed multimodal conditions. Comparison to a younger sample suggests age-related amodal processing declines.
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Is markerless acquisition technique adequate for speech production?
Yesterday, 27 Ιουνίου 2016, 6:57:18 μμ | Αλέξανδρος Σφακιανάκης
In this study, the precision of markerless acquisition techniques have been assessed when used to acquire articulatory data for speech production studies. Two different markerless systems have been evaluated and compared to a marker-based one. The main finding is that both markerless systems provide a reasonable result during normal speech and the quality is uneven during fast articulated speech. The quality of the data is dependent on the temporal resolution of the markerless system.
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Proteomics of Papillary Thyroid Carcinoma
Yesterday, 27 Ιουνίου 2016, 5:27:46 μμ | Αλέξανδρος Σφακιανάκης
Condition: Papillary Thyroid Carcinoma
Intervention:
Sponsor: The Affiliated Hospital of Inner Mongolia Medical University
Recruiting - verified June 2016
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Intervention:
Sponsor: The Affiliated Hospital of Inner Mongolia Medical University
Recruiting - verified June 2016
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S-1 Concurrent With Radiotherapy Versus Radiotherapy for Elderly Patients With Esophageal Cancer
Yesterday, 27 Ιουνίου 2016, 5:27:46 μμ | Αλέξανδρος Σφακιανάκης
Conditions: Esophageal Cancer; Chemoradiation
Interventions: Radiation: Radiotherapy 54 Gy; Radiation: Radiotherapy 60 Gy; Drug: S-1
Sponsor: Zhejiang Cancer Hospital
Recruiting - verified June 2016
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Interventions: Radiation: Radiotherapy 54 Gy; Radiation: Radiotherapy 60 Gy; Drug: S-1
Sponsor: Zhejiang Cancer Hospital
Recruiting - verified June 2016
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Diagnostic Value of 18F-Choline PET/CT in Patients With a Thyroid Nodule With an Indeterminate Cytology: Pilot Study
Yesterday, 27 Ιουνίου 2016, 5:27:46 μμ | Αλέξανδρος Σφακιανάκης
Condition: Thyroid Gland
Intervention: Device: Radiation : PET-CT with F18-choline examination
Sponsors: Centre Francois Baclesse; Canceropôle Nord Ouest
Recruiting - verified May 2016
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Intervention: Device: Radiation : PET-CT with F18-choline examination
Sponsors: Centre Francois Baclesse; Canceropôle Nord Ouest
Recruiting - verified May 2016
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OtoRhinoLaryngology & Medicine,New Articles,June 27th,2016,afternoon
Yesterday, 27 Ιουνίου 2016, 3:05:36 μμ
Diagnostic dilemmas of high grade transformation (Richter’s syndrome) of chronic lymphocytic leukaemia: results of the phase II NCRI CHOP-OR clinical trial specialist haemato-pathology central review Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα Abstract Aims Richter’s syndrome refers to high grade transformation of B-cell chronic lymphocytic leukaemia (CLL), usually to diffuse large B-cell lymphoma (DLBCL), as assessed by strict World Health Organisation (WHO)-defined histological criteria. Although a relatively evidence-poor area, the recommended clinical management of high grade transformation differs considerably from relapsed CLL. The ‘CHOP-OR’ trial was a single arm, multi-centre, non-randomised phase II NCRI trial in patients with newly diagnosed Richter’s syndrome, recruiting from across the UK from April 2011 to… περισσότερα » Classification of TP53 mutations and HPV predict survival in advanced larynx cancer Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα [image: cover.gif?v=1&s=fdf3bf895114aa3ba0986593] Objectives/Hypothesis Assess tumor suppressor p53 (*TP53*) functional mutations in the context of other biomarkers in advanced larynx cancer. Study Design Prospective analysis of pretreatment tumor *TP53*, human papillomavirus (HPV), Bcl-xL, and cyclin D1 status in stage III and IV larynx cancer patients in a clinical trial. Methods *TP53* exons 4 through 9 from 58 tumors were sequenced. Mutations were grouped using three classifications based on their expected function. Each functional group was analyzed for response to induction … περισσότερα » Singing voice outcomes following singing voice therapy Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα [image: cover.gif?v=1&s=fdf3bf895114aa3ba0986593] Objectives/Hypothesis The objectives of this study were to describe singing voice therapy (SVT), describe referred patient characteristics, and document the outcomes of SVT. Study Design Retrospective. Methods Records of patients receiving SVT between June 2008 and June 2013 were reviewed (n = 51). All diagnoses were included. Demographic information, number of SVT sessions, and symptom severity were retrieved from the medical record. Symptom severity was measured via the 10-item Singing Voice Handicap Index (SVHI-10). Treatment ou… περισσότερα » Smoking cessation is associated with improved survival in oropharynx cancer treated by chemoradiation Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα Objectives/Hypothesis The effect of smoking and human papillomavirus (HPV) on overall survival (OS) of oropharyngeal squamous cell carcinoma (OPSCC) patients undergoing concurrent chemotherapy (CCRT) remains unclear. Study Design Retrospective review. Methods Clinical characteristics of OPSCC patients treated between 2008 and 2015 with CCRT were abstracted from medical records. OS curves and multivariate cox proportional hazard ratios (HRs) were examined. Results Of 120 evaluable patients, 71% had HPV+ tumors. Median follow-up duration for the entire cohort was 41.5 months (range =… περισσότερα » In reference to Spontaneous middle cranial fossa cerebrospinal fluid otorrhea in adults Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα [image: cover.gif?v=1&s=fdf3bf895114aa3ba0986593] from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/28VmWsF via IFTTT περισσότερα » Age-associated decrease in GDNF and its cognate receptor GFRα-1 protein expression in human skin Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα Summary Glial cell line-derived neurotrophic factor (GDNF) and its cognate receptor (GFRα-1) are expressed in normal human skin. They are involved in murine hair follicle morphogenesis and cycling control. We hypothesize that ‘GDNF and GFRα-1 protein expression in human skin undergoes age-associated alterations. To test our hypothesis, the expression of these proteins was examined in human skin specimens obtained from 30 healthy individuals representing three age groups: children (5–18 years), adults (19–60 years) and the elderly (61–81 years). Immunofluorescent and light microscopi… περισσότερα » Identification of a Forensically and Medically Important Blowfly: A Case Study of Adult Calliphora vicina (Rob-Desvoidy) in TurkeyIdentification of Adult Calliphora vicina Alexandros G. SfakianakisστοΝοσολογίαΠριν από 25 δευτερόλεπτα 2016-06-27T03-13-27Z *Source:* European Journal of Forensic Sciences Halide Nihal ACIKGOZ, Duygu DIVRAK, Meriem TALEB. Background: Blowflies are a group of species which belong to Calliphoridae family, and they often colonize human and animal corpses. Being the first species to settle on cadavers, they have become of great forensic importance. They lay their eggs on corpses and play a crucial role in the decomposition process. Many species of blowflies appear globally while some of them live in certain regions. Calliphora vicina (Robineau-Desvoidy, 1830) (Diptera, Calliphoridae) is a … περισσότερα » Functional Role of Milk Fat Globule-Epidermal Growth Factor VIII in Macrophage-Mediated Inflammatory Responses and Inflammatory/Autoimmune Diseases Alexandros G. SfakianakisστοΝοσολογίαΠριν από 25 δευτερόλεπτα Inflammation involves a series of complex biological processes mediated by innate immunity for host defense against pathogen infection. Chronic inflammation is considered to be one of the major causes of serious diseases, including a number of autoimmune/inflammatory diseases, cancers, cardiovascular diseases, and neurological diseases. Milk fat globule-epidermal growth factor 8 (MFG-E8) is a secreted protein found in vertebrates and was initially discovered as a critical component of the milk fat globule. Previously, a number of studies have reported that MFG-E8 contributes to vari… περισσότερα » Characterization of the Blood Brain Barrier in Pediatric Central Nervous System Neoplasms Alexandros G. SfakianakisστοΝοσολογίαΠριν από 25 δευτερόλεπτα 2016-06-27T01-48-02Z *Source:* Journal of Interdisciplinary Histopathology Christopher S Hong, Winson Ho, Martin G Piazza, Abhik Ray-Chaudhury, Zhengping Zhuang, John D Heiss. Objective: The normal bloodbrain barrier (BBB) is composed of tight junctions between endothelial cells and surrounding astrocyte foot processes. Breakdown of the physiological astrocyte-endothelial cell relationship occurs in adult metastatic and primary brain tumors. However, the astrocyte-endothelial cell relationship has not been studied in pediatric tumors. Materials and Methods: Utilizing specimens from ca… περισσότερα » Transoral robotic base of tongue reduction for obstructive sleep apnea Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 25 δευτερόλεπτα
A systematic review and meta-analysis: [image: cover.gif?v=1&s=fdf3bf895114aa3ba0986593] Objectives/Hypothesis To determine the effect of transoral robotic surgery (TORS) base of tongue (BOT) reduction on sleep-related outcomes in patients with obstructive sleep apnea (OSA). Data Sources PubMed, Scopus, EMBASE, CINAHL, Cochrane, and Ovid. Review Methods Literature search by two independent authors was conducted using the abovementioned databases. Studies on TORS BOT reduction as part of OSA treatment in adult patients with pre- and postoperative apnea–hypopnea index (AHI) scores … περισσότερα » Cochlear implantation for single-sided deafness Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 25 δευτερόλεπτα A multicenter study: [image: cover.gif?v=1&s=fdf3bf895114aa3ba0986593] Objectives/Hypothesis To report the preliminary outcomes of patients with single-sided deafness and asymmetric hearing loss undergoing cochlear implantation at two centers. Study Design Retrospective review and prospective data collection. Methods Patients with single-sided deafness who underwent cochlear implantation at two centers were included. Pre- and postoperative measures included monosyllabic word and sentence recognition in quiet for the ear implanted, and sentence recognition in noise in the best-aide… περισσότερα » Midline posterior glossectomy and LT are beneficial in normal weight and overweight children with DS who have persistent OSA following TA and are intolerant of PAP therapy Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 25 δευτερόλεπτα Midline posterior glossectomy and lingual tonsillectomy in obese and nonobese children with down syndrome: Biomarkers for success: Objectives/Hypothesis To examine outcomes following midline posterior glossectomy (MPG) plus lingual tonsillectomy (LT) for the treatment of significant obstructive sleep apnea (OSA) in children with Down syndrome (DS). Methods Patients with DS who had persistent OSA following tonsillectomy and adenoidectomy (TA) and were relatively intolerant of positive airway pressure (PAP) therapy were evaluated by physical examination and sleep/CINE magnetic resonan… περισσότερα » Use of a NIM system to identify the functional separation between inclusion and exclusion branches of the hypoglossal nerve for implantation of a selective upper-airway stimulation system. Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 25 δευτερόλεπτα Nerve monitoring-guided selective hypoglossal nerve stimulation in obstructive sleep apnea patients: [image: cover.gif?v=1&s=fdf3bf895114aa3ba0986593] Objective/Hypothesis Selective stimulation of the upper airway is a new therapy for obstructive sleep apnea. The aim of the study was to determine if a selective nerve integrity monitoring (NIM) system could aid in precise placement of the cuff electrode in selective upper-airway stimulation. Study Design Single-center, prospective clinical trial. Methods Twenty patients who received a selective upper-airway stimulation system (Ins… περισσότερα » Neuroendocrine Adenoma of the Middle Ear Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 25 δευτερόλεπτα A Rare Histopathological Diagnosis: Neuroendocrine tumours occur throughout the body but are rare in the head and neck region and particularly rare in the middle ear. Clinical findings are often nonspecific and therefore pose a diagnostic challenge. Furthermore, the nomenclature of neuroendocrine tumours of the middle ear is historically controversial. Herein a case is presented of a middle ear adenoma in a 33-year-old patient who presented with otalgia, hearing loss, and facial nerve palsy. A brief discussion is included regarding the histopathological features of middle ear adeno… περισσότερα » Chirp Stimuli in ABR/ASSR Measurement Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 25 δευτερόλεπτα 
Update on Auditory Evoked Responses: Value of Chirp Stimuli in ABR/ASSR Measurement: When I first heard about chirps many years ago, none of the clinical ABR systems had chirps as stimuli. As time went on, some of the manufacturers began to introduce chirps. As with any other new development, they were heavily promoted. However, I was not going to start using a new type of stimulus when the existing stimuli - traditional tone bursts and clicks - worked just fine. I kept an open mind, but I looked for evidence. Today, there is plenty of evidence for the use of chirps. περισσότερα » OtoRhinoLaryngology Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 25 δευτερόλεπτα 11m OtoRhinoLaryngology - Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader Neuroendocrine Adenoma of the Middle Ear: A Rare Histopathological Diagnosis Neuroendocrine tumours occur throughout the body but are rare in the head and neck region and particularly rare in the middle ear. Clinical findings are often nonspecific and therefore pose a diagnostic challenge. Furthermore, the nomenclature of neuroendocrine tumours of the middle ear is historically… 1h OtoRhinoLaryngology - Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader Nerve monitoring… περισσότερα » Head and Neck on PubMed Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 25 δευτερόλεπτα - Pharmacological preconditioning for short-term ex vivo expansion of human umbilical cord blood hematopoietic stem cells by filgrastim.Grigoriadis NG, Grigoriadis IG, Markoula S, Paschopoulos M, Zikopoulos K, Apostolakopoulos PG, Vizirianakis IS, Georgiou I, 2016-06-27 11:28:25 AM Related Articles *Pharmacological preconditioning for short-term ex vivo expansion of human umbilical cord blood hematopoietic stem cells by filgrastim.* Am J Stem Cells. 2016;5(1):29-38 Authors: Grigoriadis NG, Grigoriadis IG, Markoula S, Paschopoulos M, Zikopoulos K, Aposto… περισσότερα » Head and Neck on PubMed Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 25 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates Pharmacological preconditioning for short-term ex vivo expansion of human umbilical cord blood hematopoietic stem cells by filgrastim. Today, 27 Ιουνίου 2016, 3 hours ago | Grigoriadis NG, Grigoriadis IG, Markoula S, Paschopoulos M, Zikopoulos K, Apostolakopoulos PG, Vizirianakis IS, Georgiou I[image: Go to full article] Related Articles*Pharmacological preconditioning for short-term ex vivo expansion of human umbilical cord blood hematopoietic stem cel… περισσότερα » Exploration of the Dietary and Lifestyle Behaviors and Weight Status and Their Self-Perceptions among Health Sciences University Students in North Lebanon Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 29 δευτερόλεπτα University students may experience significant environmental changes that exert a negative influence on the quality of their diet and lifestyle. There is scarcity of data concerning the dietary and lifestyle behaviors and weight status of students in the health field in North Lebanon. To investigate these data, a cross-sectional survey was conducted including 369 health sciences students aged 18–25 chosen from four public and private universities in North Lebanon. Data were collected using a standardized interview questionnaire to determine sociodemographic, dietary, and lifestyle… περισσότερα » Pharmaceuticals, Vol. 9, Pages 36: Site-Specific Labeling of Protein Kinase CK2: Combining Surface Display and Click Chemistry for Drug Discovery Applications Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 29 δευτερόλεπτα Human CK2 is a heterotetrameric constitutively active serine/threonine protein kinase and is an emerging target in current anti-cancer drug discovery. The kinase is composed of two catalytic CK2α subunits and two regulatory CK2β subunits. In order to establish an assay to identify protein-protein-interaction inhibitors (PPI) of the CK2α/CK2β interface, a bioorthogonal click reaction was used to modify the protein kinase α-subunit with a fluorophore. By expanding the genetic code, the unnatural amino acid para azidophenylalanine (pAzF) could be incorporated into CK2α. Performing th… περισσότερα » Materials, Vol. 9, Pages 520: Curcumin and Osteosarcoma: Can Invertible Polymeric Micelles Help? Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα Systematic review of experimental and clinical data on the use of curcumin in the treatment of osteosarcoma is presented. The current status of curcumin’s therapeutic potential against bone cancer is analyzed in regard to using polymeric micelles (including recently developed invertible, responsive, micelles) as a platform for curcumin delivery to treat osteosarcoma. The potential of micellar assemblies from responsive macromolecules in a controlled delivery of curcumin to osteosarcoma cells, and the release using a new inversion mechanism is revealed. from #Medicine via ola Kala … περισσότερα » Sports, Vol. 4, Pages 36: Differences in Spatial Physical Activity Patterns between Weekdays and Weekends in Primary School Children: A Cross-Sectional Study Using Accelerometry and Global Positioning System Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα Targeting the weekend to promote physical activity (PA) in children seems to be promising given that they tend to be less physically active and, particularly, as the age-related decline in PA is more marked during weekends. Considering the ambiguity of why children are not able to maintain their PA level on weekends, the aim of the present study was to objectively investigate differences in children’s spatial PA patterns between week and weekend days using the combination of Global Positioning System (GPS) and accelerometry. Seventy-four second graders (aged 7–9 years) and 98 sixt… περισσότερα » Sensors, Vol. 16, Pages 980: On Curating Multimodal Sensory Data for Health and Wellness Platforms Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα In recent years, the focus of healthcare and wellness technologies has shown a significant shift towards personal vital signs devices. The technology has evolved from smartphone-based wellness applications to fitness bands and smartwatches. The novelty of these devices is the accumulation of activity data as their users go about their daily life routine. However, these implementations are device specific and lack the ability to incorporate multimodal data sources. Data accumulated in their usage does not offer rich contextual information that is adequate for providing a holistic v… περισσότερα » Cells, Vol. 5, Pages 29: Epithelial Intermediate Filaments: Guardians against Microbial Infection? Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα Intermediate filaments are abundant cytoskeletal components of epithelial tissues. They have been implicated in overall stress protection. A hitherto poorly investigated area of research is the function of intermediate filaments as a barrier to microbial infection. This review summarizes the accumulating knowledge about this interaction. It first emphasizes the unique spatial organization of the keratin intermediate filament cytoskeleton in different epithelial tissues to protect the organism against microbial insults. We then present examples of direct interaction between viral, … περισσότερα » Photonics, Vol. 3, Pages 41: Engineering Multi-Section Quantum Cascade Lasers for Broadband Tuning Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα In an effort to overcome current limitations to electrical tuning of quantum cascade lasers, a strategy is proposed which combines heterogeneous quantum cascade laser gain engineering with sampled grating architectures. This approach seeks to not only widen the accessible spectral range for an individual emitter, but also compensate for functional non-uniformity of reflectivity and gain lineshapes. A trial laser with a dual wavelength core is presented which exhibits electroluminescence over a 750 cm−1 range and discrete single mode laser emission over a 700 cm−1 range. Electrical … περισσότερα » Energies, Vol. 9, Pages 491: Frequency-Splitting-Free Synchronous Tuning of Close-Coupling Self-Oscillating Wireless Power Transfer Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα The synchronous tuning of the self-oscillating wireless power transfer (WPT) in a close-coupling condition is studied in this paper. The Hamel locus is applied to predict the self-oscillating points in the WPT system. In order to make the system operate stably at the most efficient point, which is the middle resonant point when there are middle resonant and split frequency points caused by frequency-splitting, the receiver (RX) rather than the transmitter (TX) current is chosen as the self-oscillating feedback variable. The automatic delay compensation is put forward to eliminate … περισσότερα » Land, Vol. 5, Pages 21: Agriculture on the Brink: Climate Change, Labor and Smallholder Farming in Botswana Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα Botswana is a semi-arid, middle-income African country that imports 90 percent of its food. Despite its relative prosperity, Botswana also suffers from one of the highest measures of income inequality in the world, persistent poverty, and relatively high levels of food insecurity. The objective of this paper is to explore how political economy, climate change and livelihood dynamics are synergistically impacting household food security. The major finding is that the marginalization of smallholder farming in Botswana has as much or more to do with domestic, regional and internation… περισσότερα » Horticulturae, Vol. 2, Pages 7: An Overview of Fertilization and Irrigation Management in the Conventional and Certified Organic Production of Vegetable Crops in Florida Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα The postharvest quality of vegetable crops from conventional and organic production systems depends on pre-harvest factors such as variety genetic potential, fertilization, and irrigation. The five principles of plant nutrition (plants absorb ions, not fertilizers; Leibeig’s law of the minimum; nutrient application requires a source, a rate, a placement and a time of application; no correlation exists between total nutrient presence in the soil and availability; and plant nutrient concentration and yield are related) must be followed throughout the crop growth cycle. In certified … περισσότερα » Horticulturae, Vol. 2, Pages 6: Estimating the Leaf Area of Cut Roses in Different Growth Stages Using Image Processing and Allometrics Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα Non-destructive, accurate, user-friendly and low-cost approaches to determining crop leaf area (LA) are a key tool in many agronomic and physiological studies, as well as in current agricultural management. Although there are models that estimate cut rose LA in the literature, they are generally designed for a specific stage of the crop cycle, usually harvest. This study aimed to estimate the LA of cut “Red Naomi” rose stems in several phenological phases using morphological descriptors and allometric measurements derived from image processing. A statistical model was developed ba… περισσότερα » Energies, Vol. 9, Pages 492: Hybrid Modulation of Bidirectional Three-Phase Dual-Active-Bridge DC Converters for Electric Vehicles Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα Bidirectional power converters for electric vehicles (EVs) have received much attention recently, due to either grid-supporting requirements or emergent power supplies. This paper proposes a hybrid modulation of the three-phase dual-active bridge (3ΦDAB) converter for EV charging systems. The designed hybrid modulation allows the converter to switch its modulation between phase-shifted and trapezoidal modes to increase the conversion efficiency, even under light-load conditions. The mode transition is realized in a real-time manner according to the charging or discharging current…. περισσότερα » Peptide drugs accelerate BMP-2-induced calvarial bone regeneration and stimulate osteoblast differentiation through mTORC1 signaling Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα Both W9 and OP3-4 were known to bind the receptor activator of NF-κB ligand (RANKL), inhibiting osteoclastogenesis. Recently, both peptides were shown to stimulate osteoblast differentiation; however, the mechanism underlying the activity of these peptides remains to be clarified. A primary osteoblast culture showed that rapamycin, an mTORC1 inhibitor, which was recently demonstrated to be an important serine/threonine kinase for bone formation, inhibited the peptide-induced alkaline phosphatase activity. Furthermore, both peptides promoted the phosphorylation of Akt and S6K1, an … περισσότερα » Effect of Aurantii Fructus Immaturus Flavonoid on the Contraction of Isolated Gastric Smooth Muscle Strips in Rats Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα This study was designed to investigate the effect of Aurantii fructus immaturus flavonoid (AFIF) on the contraction of isolated gastric smooth muscle in rats and explore its underlying mechanisms. Isolated antral longitudinal smooth muscle strip (ALSMS) and pyloric circular smooth muscle strip (PCSMS) of rats were suspended in tissue chambers. The responses of ALSMS and PCSMS to administration of AFIF were observed. Cyclic guanosine monophosphate (cGMP) and protein kinase G (PKG) levels of PCSMS were measured by ELISA kits. In this study, AFIF showed no significant effect on ALSMS… περισσότερα » Antibacterial and Antibiofilm Activity of Methanolic Plant Extracts against Nosocomial Microorganisms Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα Biofilm is a complex microbial community highly resistant to antimicrobials. The formation of biofilms in biotic and abiotic surfaces is associated with high rates of morbidity and mortality in hospitalized patients. New alternatives for controlling infections have been proposed focusing on the therapeutic properties of medicinal plants and their antimicrobial effects. In the present study the antimicrobial and antibiofilm activities of 8 methanolic plant extracts were evaluated against clinical isolated microorganisms. Preliminary screening by diffusion well assay showed the anti… περισσότερα » Pharmacological preconditioning for short-term ex vivo expansion of human umbilical cord blood hematopoietic stem cells by filgrastim. Alexandros G. SfakianakisστοHead and NeckΠριν από 30 δευτερόλεπτα Related Articles *Pharmacological preconditioning for short-term ex vivo expansion of human umbilical cord blood hematopoietic stem cells by filgrastim.* Am J Stem Cells. 2016;5(1):29-38 Authors: Grigoriadis NG, Grigoriadis IG, Markoula S, Paschopoulos M, Zikopoulos K, Apostolakopoulos PG, Vizirianakis IS, Georgiou I Abstract Although umbilical cord blood (UCB) hematopoietic stem cell transplantation (UCBT) has emerged as a promising haematological reconstitution therapy for leukemias and other related disorders, the insufficient UCB stem cell dosage still hinders better clinical … περισσότερα » Induction of sensory neurons from neuroepithelial stem cells by the ISX9 small molecule. Alexandros G. SfakianakisστοHead and NeckΠριν από 30 δευτερόλεπτα Related Articles *Induction of sensory neurons from neuroepithelial stem cells by the ISX9 small molecule.* Am J Stem Cells. 2016;5(1):19-28 Authors: Ali RQ, Blomberg E, Falk A, Ährlund-Richter L, Ulfendahl M Abstract Hearing impairment most often involves loss of sensory hair cells and auditory neurons. As this loss is permanent in humans, a cell therapy approach has been suggested to replace damaged cells. It is thus of interest to generate lineage restricted progenitor cells appropriate for cell based therapies. Human long-term self-renewing neuroepithelial stem (lt-NES) cell … περισσότερα » Influence of paternal preconception exposures on their offspring: through epigenetics to phenotype. Alexandros G. SfakianakisστοHead and NeckΠριν από 30 δευτερόλεπτα Related Articles *Influence of paternal preconception exposures on their offspring: through epigenetics to phenotype.* Am J Stem Cells. 2016;5(1):11-8 Authors: Day J, Savani S, Krempley BD, Nguyen M, Kitlinska JB Abstract Historically, research into congenital defects has focused on maternal impacts on the fetal genome during gestation and prenatal periods. However, recent findings have sparked interest in epigenetic alterations of paternal genomes and its effects on offspring. This emergent field focuses on how environmental influences can epigenetically alter gene expression and… περισσότερα » Comparison of stem cell therapies for acute kidney injury. Alexandros G. SfakianakisστοHead and NeckΠριν από 30 δευτερόλεπτα Related Articles *Comparison of stem cell therapies for acute kidney injury.* Am J Stem Cells. 2016;5(1):1-10 Authors: Barnes CJ, Distaso CT, Spitz KM, Verdun VA, Haramati A Abstract Acute kidney injury (AKI) is the rapid onset of decreased kidney function that ultimately increases mortality and morbidity. Stem cell research is a promising avenue for curative and preventative therapies of kidney injury, however, there are many types of stem cells under investigation. Currently there is no research to compare the value of one stem cell method over another. Induced pluripotent stem … περισσότερα » miR-376c inhibits cervical cancer cell proliferation and invasion by targeting BMI1 medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 34 δευτερόλεπτα 
Summary MicroRNAs (miRNAs) play crucial roles in cancer development and progression. The purposes of this study were to explore the role of miR-376c in cervical cancer and to clarify the regulation of BMI1 by miR-376c. Quantitative RT-PCR was used to measure miR-376c expression in cervical cancer tissues and cell lines. The cell proliferation, cell cycle […] περισσότερα » miR-376c inhibits cervical cancer cell proliferation and invasion by targeting BMI1 medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 34 δευτερόλεπτα 
Summary MicroRNAs (miRNAs) play crucial roles in cancer development and progression. The purposes of this study were to explore the role of miR-376c in cervical cancer and to clarify the regulation of BMI1 by miR-376c. Quantitative RT-PCR was used to measure miR-376c expression in cervical cancer tissues and cell lines. The cell proliferation, cell cycle […] περισσότερα » Development of Hemolytic Anemia in a Nivolumab-Treated Patient with Refractory Metastatic Squamous Cell Skin Cancer and Chronic Lymphatic Leukemia medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 34 δευτερόλεπτα 
Management of patients with metastatic squamous cell skin cancer, refractory to initial therapy with standard chemotherapy and radiation protocols, remains difficult with poor overall prognosis and limited therapeutic options. Recently, promising response rates with nivolumab, a programmed death receptor-1-blocking antibody, in squamous cancer of the head and neck have been demonstrated. Considering the similar histological […] περισσότερα » A Giant Retroperitoneal Liposarcoma Encasing the Entire Left Kidney and Adherent to Adjacent Structures: A Case Report medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 34 δευτερόλεπτα 
Retroperitoneal liposarcoma is a rare tumor. The dimension and weight of liposarcoma are variable; those over 20 kg are called ‘giant liposarcoma’. Herein, we report giant retroperitoneal liposarcoma measuring 45 cm in diameter and 25 kg in weight encasing the entire left kidney and adherent to adjacent structures. A 71-year-old woman presented for a regular […] περισσότερα » Pazopanib in Primary Cardiac Angiosarcoma of the Right Atrium: A Case Report medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 34 δευτερόλεπτα 
Primary heart tumors are an extremely rare oncological entity with primary cardiac sarcomas usually representing 20% of all primary cardiac tumorous lesions [Shanmugam: Eur J Cardiothorac Surg 2006;29: 925–932; Orlandi et al.: J Thorac Oncol 2010;5: 1483–1489]. Angiosarcoma is the most prevalent histology and despite a multidisciplinary approach tends to have a dismal prognosis [Shanmugam: […] περισσότερα » Postictal Magnetic Resonance Imaging Changes Masquerading as Brain Tumor Progression: A Case Series medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 34 δευτερόλεπτα 
Seizures are common among patients with brain tumors. Transient, postictal magnetic resonance imaging abnormalities are a long recognized phenomenon. However, these radiographic changes are not as well studied in the brain tumor population. Moreover, reversible neuroimaging abnormalities following seizure activity may be misinterpreted for tumor progression and could consequently result in unnecessary tumor-directed treatment. Here, […] περισσότερα » Arriving at the Right Diagnosis in an Era of Precision Medicine medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 34 δευτερόλεπτα 
In the era of precision medicine and targeted therapy, diagnostic inaccuracy can have tremendous ramifications. We present the case of a 61-year-old man initially diagnosed with small cell lung cancer by pathology. Prior to initiating chemotherapy, multidisciplinary discussions led to an amendment of the diagnosis to medullary thyroid cancer. Case Rep Oncol 2016;9:351–357 from #Medicine-SfakianakisAlexandros […] περισσότερα » A Case of Malignant Gastrointestinal Stromal Tumor Initially Misdiagnosed as Malignant B-Cell Lymphoma medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 34 δευτερόλεπτα 
Errors that occur in anatomic pathology influence the treatment strategy of patients with malignancy. There are four general types of error with three subtypes in the category of defective interpretation. The first subtype is a false-negative diagnosis or undercall of the extent or severity of the lesion, the second is a false-positive diagnosis, and the […] περισσότερα » Sources of protons and a role for bicarbonate in inhibitory feedback from horizontal cells to cones in Ambystoma tigrinum retina Alexandros G. SfakianakisστοPhysiology by Alexandros G.SfakianakisΠριν από 37 δευτερόλεπτα Abstract Lateral-inhibitory feedback from horizontal cells (HCs) to photoreceptors involves changes in synaptic cleft pH accompanying light-evoked changes in HC membrane potential. We analyzed HC to cone feedback by studying surround-evoked light responses of cones and by obtaining paired whole cell recordings from cones and HCs in salamander retina. We tested three potential sources for synaptic cleft protons: 1) generation by extracellular carbonic anhydrase (CA), 2) release from acidic synaptic vesicles, and 3) Na+/H+ exchangers (NHEs). Neither antagonizing extracellular CA nor … περισσότερα » Neuroendocrine Adenoma of the Middle Ear: A Rare Histopathological Diagnosis otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 37 δευτερόλεπτα 
Neuroendocrine tumours occur throughout the body but are rare in the head and neck region and particularly rare in the middle ear. Clinical findings are often nonspecific and therefore pose a diagnostic challenge. Furthermore, the nomenclature of neuroendocrine tumours of the middle ear is historically controversial. Herein a case is presented of a middle ear […] περισσότερα » Nerve monitoring-guided selective hypoglossal nerve stimulation in obstructive sleep apnea patients otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 37 δευτερόλεπτα 
Objective/Hypothesis Selective stimulation of the upper airway is a new therapy for obstructive sleep apnea. The aim of the study was to determine if a selective nerve integrity monitoring (NIM) system could aid in precise placement of the cuff electrode in selective upper-airway stimulation. Study Design Single-center, prospective clinical trial. Methods Twenty patients who received […] περισσότερα » Midline posterior glossectomy and lingual tonsillectomy in obese and nonobese children with down syndrome: Biomarkers for success otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 37 δευτερόλεπτα 
Objectives/Hypothesis To examine outcomes following midline posterior glossectomy (MPG) plus lingual tonsillectomy (LT) for the treatment of significant obstructive sleep apnea (OSA) in children with Down syndrome (DS). Methods Patients with DS who had persistent OSA following tonsillectomy and adenoidectomy (TA) and were relatively intolerant of positive airway pressure (PAP) therapy were evaluated by physical […] περισσότερα » Cochlear implantation for single-sided deafness: A multicenter study otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 37 δευτερόλεπτα 
Objectives/Hypothesis To report the preliminary outcomes of patients with single-sided deafness and asymmetric hearing loss undergoing cochlear implantation at two centers. Study Design Retrospective review and prospective data collection. Methods Patients with single-sided deafness who underwent cochlear implantation at two centers were included. Pre- and postoperative measures included monosyllabic word and sentence recognition in quiet […] περισσότερα » Managing blocked foley catheter balloons when removing posterior nasal packs in epistaxis patients otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 37 δευτερόλεπτα 
Level of Evidence NA Laryngoscope, 2016 from #ORL via xlomafota13 on Inoreader http://ift.tt/294r4KW via IFTTT http://ift.tt/28X7r5v περισσότερα » Transoral robotic base of tongue reduction for obstructive sleep apnea: A systematic review and meta-analysis otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 37 δευτερόλεπτα 
Objectives/Hypothesis To determine the effect of transoral robotic surgery (TORS) base of tongue (BOT) reduction on sleep-related outcomes in patients with obstructive sleep apnea (OSA). Data Sources PubMed, Scopus, EMBASE, CINAHL, Cochrane, and Ovid. Review Methods Literature search by two independent authors was conducted using the abovementioned databases. Studies on TORS BOT reduction as part […] περισσότερα » Extended and treatment-oriented classification of parotid duct stenosis otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 37 δευτερόλεπτα 
Objectives/Hypothesis To provide an extended and treatment-oriented classification of parotid duct stenosis that might be useful in the management of this condition. Study Design Retrospective study in a tertiary referral center. Methods A total of 550 symptomatic stenoses of the parotid gland excretory duct in 445 patients were analyzed. Sialendoscopy was performed with semirigid endoscopes. […] περισσότερα » Review of videolaryngoscopy pharyngeal wall injuries otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 37 δευτερόλεπτα 
Objectives Reports of patient injuries associated with videolaryngoscopy are increasing in the literature. There are a wide variety of opinions regarding both safe use of the device and patient care following aerodigestive tract injury. We have seen an increase in videolaryngoscopy-associated injuries in recent years at our institution. Because of this, we wanted to determine […] περισσότερα » Cochlear implantation via round window or cochleostomy: Effect on hearing in an animal model otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 37 δευτερόλεπτα 
Objectives/Hypothesis Cochlear implantation in patients with residual hearing has increased interest in hearing preservation. Two major surgical approaches to implantation have been devised: via the round window membrane and through cochleostomy. However, the advantages of either approach on hearing preservation have not been established. Due to the great inter- and intravariability among implantees, the current […] περισσότερα » Long-term antibiofilm activity of carboxymethyl chitosan on mixed biofilm on silicone otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 37 δευτερόλεπτα 
Objectives/Hypothesis Silicone voice prostheses are most frequently used in voice rehabilitation of laryngectomized patients. However, the functional device lifetimes are limited due to formation of mixed biofilms. Existing in vitro models simulating biofilm formation are restricted to only short-term periods. Study Design The goal of this study was to determine the effect of carboxymethyl chitosan […] περισσότερα » Development of Hemolytic Anemia in a Nivolumab-Treated Patient with Refractory Metastatic Squamous Cell Skin Cancer and Chronic Lymphatic Leukemia Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 39 δευτερόλεπτα Management of patients with metastatic squamous cell skin cancer, refractory to initial therapy with standard chemotherapy and radiation protocols, remains difficult with poor overall prognosis and limited therapeutic options. Recently, promising response rates with nivolumab, a programmed death receptor-1-blocking antibody, in squamous cancer of the head and neck have been demonstrated. Considering the similar histological patterns of squamous cell cancer of the skin and squamous cell cancer of the head and neck, we assumed that nivolumab could also be effective in our patients w… περισσότερα » A Giant Retroperitoneal Liposarcoma Encasing the Entire Left Kidney and Adherent to Adjacent Structures: A Case Report Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 39 δευτερόλεπτα Retroperitoneal liposarcoma is a rare tumor. The dimension and weight of liposarcoma are variable; those over 20 kg are called 'giant liposarcoma’. Herein, we report giant retroperitoneal liposarcoma measuring 45 cm in diameter and 25 kg in weight encasing the entire left kidney and adherent to adjacent structures. A 71-year-old woman presented for a regular checkup. Image study revealed a huge mass probably indicative of retroperitoneal liposarcoma encasing the entire left kidney and adherent to adjacent structures. We performed an organ-preserving surgical removal. The pathologi… περισσότερα » Postictal Magnetic Resonance Imaging Changes Masquerading as Brain Tumor Progression: A Case Series Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 39 δευτερόλεπτα Seizures are common among patients with brain tumors. Transient, postictal magnetic resonance imaging abnormalities are a long recognized phenomenon. However, these radiographic changes are not as well studied in the brain tumor population. Moreover, reversible neuroimaging abnormalities following seizure activity may be misinterpreted for tumor progression and could consequently result in unnecessary tumor-directed treatment. Here, we describe two cases of patients with brain tumors who developed peri-ictal pseudoprogression and review the relevant literature. Case Rep Oncol 2016;… περισσότερα » Pazopanib in Primary Cardiac Angiosarcoma of the Right Atrium: A Case Report Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 39 δευτερόλεπτα Primary heart tumors are an extremely rare oncological entity with primary cardiac sarcomas usually representing 20% of all primary cardiac tumorous lesions [Shanmugam: Eur J Cardiothorac Surg 2006;29: 925–932; Orlandi et al.: J Thorac Oncol 2010;5: 1483–1489]. Angiosarcoma is the most prevalent histology and despite a multidisciplinary approach tends to have a dismal prognosis [Shanmugam: Eur J Cardiothorac Surg 2006;29: 925–932; Fury et al.: Cancer J 2005;11: 241–247]. Based on the prevailing literature, we report a 48-year-old woman diagnosed with primary metastatic cardiac ang… περισσότερα » Arriving at the Right Diagnosis in an Era of Precision Medicine Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 39 δευτερόλεπτα In the era of precision medicine and targeted therapy, diagnostic inaccuracy can have tremendous ramifications. We present the case of a 61-year-old man initially diagnosed with small cell lung cancer by pathology. Prior to initiating chemotherapy, multidisciplinary discussions led to an amendment of the diagnosis to medullary thyroid cancer. Case Rep Oncol 2016;9:351–357 from Cancer via xlomafota13 on Inoreader http://ift.tt/28Y9FC7 via IFTTT http://ift.tt/28WTMKw περισσότερα » A Case of Malignant Gastrointestinal Stromal Tumor Initially Misdiagnosed as Malignant B-Cell Lymphoma Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 39 δευτερόλεπτα Errors that occur in anatomic pathology influence the treatment strategy of patients with malignancy. There are four general types of error with three subtypes in the category of defective interpretation. The first subtype is a false-negative diagnosis or undercall of the extent or severity of the lesion, the second is a false-positive diagnosis, and the third is misclassification. We herein report a 65-year-old female patient with malignant gastrointestinal stromal tumor that was diagnosed after reevaluation of the lesion at our hospital – and treated with proximal gastrectomy – … περισσότερα » Skin cancer: An effective but painful treatment Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 39 δευτερόλεπτα Skin cancer: An effective but painful treatment: FAU researchers discover why photodynamic therapy for skin cancer can cause pain. from Melanoma via ola Kala on Inoreader via IFTTT http://ift.tt/28XbXRu περισσότερα » Pharmacological preconditioning for short-term ex vivo expansion of human umbilical cord blood hematopoietic stem cells by filgrastim. Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 39 δευτερόλεπτα Related Articles *Pharmacological preconditioning for short-term ex vivo expansion of human umbilical cord blood hematopoietic stem cells by filgrastim.* Am J Stem Cells. 2016;5(1):29-38 Authors: Grigoriadis NG, Grigoriadis IG, Markoula S, Paschopoulos M, Zikopoulos K, Apostolakopoulos PG, Vizirianakis IS, Georgiou I Abstract Although umbilical cord blood (UCB) hematopoietic stem cell transplantation (UCBT) has emerged as a promising haematological reconstitution therapy for leukemias and other related disorders, the insufficient UCB stem cell dosage still hinders better clinical… περισσότερα » Induction of sensory neurons from neuroepithelial stem cells by the ISX9 small molecule. Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 39 δευτερόλεπτα Related Articles *Induction of sensory neurons from neuroepithelial stem cells by the ISX9 small molecule.* Am J Stem Cells. 2016;5(1):19-28 Authors: Ali RQ, Blomberg E, Falk A, Ährlund-Richter L, Ulfendahl M Abstract Hearing impairment most often involves loss of sensory hair cells and auditory neurons. As this loss is permanent in humans, a cell therapy approach has been suggested to replace damaged cells. It is thus of interest to generate lineage restricted progenitor cells appropriate for cell based therapies. Human long-term self-renewing neuroepithelial stem (lt-NES) cell… περισσότερα » Influence of paternal preconception exposures on their offspring: through epigenetics to phenotype. Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 39 δευτερόλεπτα Related Articles *Influence of paternal preconception exposures on their offspring: through epigenetics to phenotype.* Am J Stem Cells. 2016;5(1):11-8 Authors: Day J, Savani S, Krempley BD, Nguyen M, Kitlinska JB Abstract Historically, research into congenital defects has focused on maternal impacts on the fetal genome during gestation and prenatal periods. However, recent findings have sparked interest in epigenetic alterations of paternal genomes and its effects on offspring. This emergent field focuses on how environmental influences can epigenetically alter gene expression an… περισσότερα » Comparison of stem cell therapies for acute kidney injury. Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 39 δευτερόλεπτα Related Articles *Comparison of stem cell therapies for acute kidney injury.* Am J Stem Cells. 2016;5(1):1-10 Authors: Barnes CJ, Distaso CT, Spitz KM, Verdun VA, Haramati A Abstract Acute kidney injury (AKI) is the rapid onset of decreased kidney function that ultimately increases mortality and morbidity. Stem cell research is a promising avenue for curative and preventative therapies of kidney injury, however, there are many types of stem cells under investigation. Currently there is no research to compare the value of one stem cell method over another. Induced pluripotent stem… περισσότερα » Pharmacological preconditioning for short-term ex vivo expansion of human umbilical cord blood hematopoietic stem cells by filgrastim. Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 39 δευτερόλεπτα Related Articles *Pharmacological preconditioning for short-term ex vivo expansion of human umbilical cord blood hematopoietic stem cells by filgrastim.* Am J Stem Cells. 2016;5(1):29-38 Authors: Grigoriadis NG, Grigoriadis IG, Markoula S, Paschopoulos M, Zikopoulos K, Apostolakopoulos PG, Vizirianakis IS, Georgiou I Abstract Although umbilical cord blood (UCB) hematopoietic stem cell transplantation (UCBT) has emerged as a promising haematological reconstitution therapy for leukemias and other related disorders, the insufficient UCB stem cell dosage still hinders better clinical… περισσότερα » Induction of sensory neurons from neuroepithelial stem cells by the ISX9 small molecule. Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 39 δευτερόλεπτα Related Articles *Induction of sensory neurons from neuroepithelial stem cells by the ISX9 small molecule.* Am J Stem Cells. 2016;5(1):19-28 Authors: Ali RQ, Blomberg E, Falk A, Ährlund-Richter L, Ulfendahl M Abstract Hearing impairment most often involves loss of sensory hair cells and auditory neurons. As this loss is permanent in humans, a cell therapy approach has been suggested to replace damaged cells. It is thus of interest to generate lineage restricted progenitor cells appropriate for cell based therapies. Human long-term self-renewing neuroepithelial stem (lt-NES) cell… περισσότερα » Influence of paternal preconception exposures on their offspring: through epigenetics to phenotype. Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 39 δευτερόλεπτα Related Articles *Influence of paternal preconception exposures on their offspring: through epigenetics to phenotype.* Am J Stem Cells. 2016;5(1):11-8 Authors: Day J, Savani S, Krempley BD, Nguyen M, Kitlinska JB Abstract Historically, research into congenital defects has focused on maternal impacts on the fetal genome during gestation and prenatal periods. However, recent findings have sparked interest in epigenetic alterations of paternal genomes and its effects on offspring. This emergent field focuses on how environmental influences can epigenetically alter gene expression an… περισσότερα » Comparison of stem cell therapies for acute kidney injury. Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 39 δευτερόλεπτα Related Articles *Comparison of stem cell therapies for acute kidney injury.* Am J Stem Cells. 2016;5(1):1-10 Authors: Barnes CJ, Distaso CT, Spitz KM, Verdun VA, Haramati A Abstract Acute kidney injury (AKI) is the rapid onset of decreased kidney function that ultimately increases mortality and morbidity. Stem cell research is a promising avenue for curative and preventative therapies of kidney injury, however, there are many types of stem cells under investigation. Currently there is no research to compare the value of one stem cell method over another. Induced pluripotent stem… περισσότερα » Intrinsic resistance to EGFR tyrosine kinase inhibitors in advanced non-small-cell lung cancer with activating EGFR mutations Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 39 δευτερόλεπτα [image: 88x31.png] from Cancer via xlomafota13 on Inoreader http://ift.tt/291wiIO via IFTTT http://ift.tt/28XSf9p περισσότερα » Association of polymorphisms in interleukin-8 gene with cancer risk: a meta-analysis of 22 case–control studies Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 39 δευτερόλεπτα [image: 88x31.png] from Cancer via xlomafota13 on Inoreader http://ift.tt/28XWAc0 via IFTTT http://ift.tt/29f8mhv περισσότερα » The evolution of combined molecular targeted therapies to advance the therapeutic efficacy in melanoma: a highlight of vemurafenib and cobimetinib Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 39 δευτερόλεπτα [image: 88x31.png] from Cancer via xlomafota13 on Inoreader http://ift.tt/293H7dA via IFTTT http://ift.tt/28XSiSL περισσότερα » miR-376c inhibits cervical cancer cell proliferation and invasion by targeting BMI1 Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 47 δευτερόλεπτα Summary MicroRNAs (miRNAs) play crucial roles in cancer development and progression. The purposes of this study were to explore the role of miR-376c in cervical cancer and to clarify the regulation of BMI1 by miR-376c. Quantitative RT-PCR was used to measure miR-376c expression in cervical cancer tissues and cell lines. The cell proliferation, cell cycle and Transwell invasion assays were performed. A luciferase reporter assay was conducted to confirm the target gene of miR-376c, and the results were validated in cervical cancer cell lines and tissues. MiR-376c was significantly d… περισσότερα » Neuroendocrine Adenoma of the Middle Ear: A Rare Histopathological Diagnosis Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 52 δευτερόλεπτα Neuroendocrine tumours occur throughout the body but are rare in the head and neck region and particularly rare in the middle ear. Clinical findings are often nonspecific and therefore pose a diagnostic challenge. Furthermore, the nomenclature of neuroendocrine tumours of the middle ear is historically controversial. Herein a case is presented of a middle ear adenoma in a 33-year-old patient who presented with otalgia, hearing loss, and facial nerve palsy. A brief discussion is included regarding the histopathological features of middle ear adenomas and seeks to clarify the correc… περισσότερα » Nerve monitoring-guided selective hypoglossal nerve stimulation in obstructive sleep apnea patients Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 52 δευτερόλεπτα [image: cover.gif?v=1&s=fdf3bf895114aa3ba0986593] Objective/Hypothesis Selective stimulation of the upper airway is a new therapy for obstructive sleep apnea. The aim of the study was to determine if a selective nerve integrity monitoring (NIM) system could aid in precise placement of the cuff electrode in selective upper-airway stimulation. Study Design Single-center, prospective clinical trial. Methods Twenty patients who received a selective upper-airway stimulation system (Inspire Medical Systems, Maple Grove, MN) were implanted by using a NIM system. The tongue motions wer… περισσότερα » Midline posterior glossectomy and lingual tonsillectomy in obese and nonobese children with down syndrome: Biomarkers for success Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 52 δευτερόλεπτα Objectives/Hypothesis To examine outcomes following midline posterior glossectomy (MPG) plus lingual tonsillectomy (LT) for the treatment of significant obstructive sleep apnea (OSA) in children with Down syndrome (DS). Methods Patients with DS who had persistent OSA following tonsillectomy and adenoidectomy (TA) and were relatively intolerant of positive airway pressure (PAP) therapy were evaluated by physical examination and sleep/CINE magnetic resonance imaging to determine the etiology of upper airway obstruction. Patients with relative macroglossia underwent MPG plus LT if … περισσότερα » Cochlear implantation for single-sided deafness: A multicenter study Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 52 δευτερόλεπτα [image: cover.gif?v=1&s=fdf3bf895114aa3ba0986593] Objectives/Hypothesis To report the preliminary outcomes of patients with single-sided deafness and asymmetric hearing loss undergoing cochlear implantation at two centers. Study Design Retrospective review and prospective data collection. Methods Patients with single-sided deafness who underwent cochlear implantation at two centers were included. Pre- and postoperative measures included monosyllabic word and sentence recognition in quiet for the ear implanted, and sentence recognition in noise in the best-aided bilateral conditi… περισσότερα » Managing blocked foley catheter balloons when removing posterior nasal packs in epistaxis patients Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 52 δευτερόλεπτα Level of Evidence NA *Laryngoscope*, 2016 from #ORL via xlomafota13 on Inoreader http://ift.tt/294r4KW via IFTTT περισσότερα » Transoral robotic base of tongue reduction for obstructive sleep apnea: A systematic review and meta-analysis Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 52 δευτερόλεπτα [image: cover.gif?v=1&s=fdf3bf895114aa3ba0986593] Objectives/Hypothesis To determine the effect of transoral robotic surgery (TORS) base of tongue (BOT) reduction on sleep-related outcomes in patients with obstructive sleep apnea (OSA). Data Sources PubMed, Scopus, EMBASE, CINAHL, Cochrane, and Ovid. Review Methods Literature search by two independent authors was conducted using the abovementioned databases. Studies on TORS BOT reduction as part of OSA treatment in adult patients with pre- and postoperative apnea–hypopnea index (AHI) scores were included. Studies on TORS as tre… περισσότερα » Extended and treatment-oriented classification of parotid duct stenosis Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 52 δευτερόλεπτα Objectives/Hypothesis To provide an extended and treatment-oriented classification of parotid duct stenosis that might be useful in the management of this condition. Study Design Retrospective study in a tertiary referral center. Methods A total of 550 symptomatic stenoses of the parotid gland excretory duct in 445 patients were analyzed. Sialendoscopy was performed with semirigid endoscopes. The tissue quality, location, grade of luminal narrowing, and length and number of the stenoses were assessed. Results Inflammation-dominant stenosis (type 1) was found in 8.9% of the pati… περισσότερα » Review of videolaryngoscopy pharyngeal wall injuries Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 52 δευτερόλεπτα [image: cover.gif?v=1&s=fdf3bf895114aa3ba0986593] Objectives Reports of patient injuries associated with videolaryngoscopy are increasing in the literature. There are a wide variety of opinions regarding both safe use of the device and patient care following aerodigestive tract injury. We have seen an increase in videolaryngoscopy-associated injuries in recent years at our institution. Because of this, we wanted to determine if video-assisted laryngoscopy presents a greater risk of injury compared with direct laryngoscopy. Furthermore, we wanted to determine if there were patien… περισσότερα » Cochlear implantation via round window or cochleostomy: Effect on hearing in an animal model Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 52 δευτερόλεπτα [image: cover.gif?v=1&s=fdf3bf895114aa3ba0986593] Objectives/Hypothesis Cochlear implantation in patients with residual hearing has increased interest in hearing preservation. Two major surgical approaches to implantation have been devised: via the round window membrane and through cochleostomy. However, the advantages of either approach on hearing preservation have not been established. Due to the great inter- and intravariability among implantees, the current study used a normal-hearing animal model to compare the effect of the two methods on hearing. Study Design Animal study… περισσότερα » Long-term antibiofilm activity of carboxymethyl chitosan on mixed biofilm on silicone Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 52 δευτερόλεπτα [image: cover.gif?v=1&s=fdf3bf895114aa3ba0986593] Objectives/Hypothesis Silicone voice prostheses are most frequently used in voice rehabilitation of laryngectomized patients. However, the functional device lifetimes are limited due to formation of mixed biofilms. Existing in vitro models simulating biofilm formation are restricted to only short-term periods. Study Design The goal of this study was to determine the effect of carboxymethyl chitosan on mixed biofilm formation of fungi and bacteria on silicone over a long-term period. Methods Mixed species biofilms of *Candida alb… περισσότερα » Mesenchymal stem cells have antifibrotic effects on transforming growth factor-β1-stimulated vocal fold fibroblasts Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 52 δευτερόλεπτα Objectives/Hypothesis Mesenchymal stem cells (MSCs) hold therapeutic promise for vocal fold scar, yet the precise mechanism(s) underlying tissue level changes remain unclear. We hypothesize that MSCs interact with native fibroblasts to favorably affect healing. Furthermore, we hypothesize that these interactions vary based on MSC source. Methods Vocal fold fibroblasts (VFFs), adipose-derived stem cells, and bone marrow-derived stem cells (BMSCs) were extracted from Sprague-Dawley rats; and a coculture model was employed culturing VFFs ± transforming growth factor (TGF-β1) (10 ng… περισσότερα » Active middle ear implant coupled bilaterally to the round window despite bilateral implanted stapes prostheses Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 52 δευτερόλεπτα [image: cover.gif?v=1&s=fdf3bf895114aa3ba0986593] After stapes surgery, patients with mixed or moderate hearing loss have limited possibilities for hearing improvement. We are reporting on a patient who underwent stapedotomy bilaterally 20 years ago and had sensorineural and mixed hearing loss. Recurrent otitis externa prevented the use of hearing aids. This patient was treated bilaterally with the Vibrant Soundbridge (Med-El, Innsbruck, Austria) successively. The Schuknecht piston stapes prostheses remained in situ. The Floating Mass Transducer (FMT; Med-El) was coupled to the ro… περισσότερα » Classification of TP53 mutations and HPV predict survival in advanced larynx cancer Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 52 δευτερόλεπτα [image: cover.gif?v=1&s=fdf3bf895114aa3ba0986593] Objectives/Hypothesis Assess tumor suppressor p53 (*TP53*) functional mutations in the context of other biomarkers in advanced larynx cancer. Study Design Prospective analysis of pretreatment tumor *TP53*, human papillomavirus (HPV), Bcl-xL, and cyclin D1 status in stage III and IV larynx cancer patients in a clinical trial. Methods *TP53* exons 4 through 9 from 58 tumors were sequenced. Mutations were grouped using three classifications based on their expected function. Each functional group was analyzed for response to inducti… περισσότερα » Singing voice outcomes following singing voice therapy Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 52 δευτερόλεπτα [image: cover.gif?v=1&s=fdf3bf895114aa3ba0986593] Objectives/Hypothesis The objectives of this study were to describe singing voice therapy (SVT), describe referred patient characteristics, and document the outcomes of SVT. Study Design Retrospective. Methods Records of patients receiving SVT between June 2008 and June 2013 were reviewed (n = 51). All diagnoses were included. Demographic information, number of SVT sessions, and symptom severity were retrieved from the medical record. Symptom severity was measured via the 10-item Singing Voice Handicap Index (SVHI-10). Treatment… περισσότερα » Smoking cessation is associated with improved survival in oropharynx cancer treated by chemoradiation Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 52 δευτερόλεπτα Objectives/Hypothesis The effect of smoking and human papillomavirus (HPV) on overall survival (OS) of oropharyngeal squamous cell carcinoma (OPSCC) patients undergoing concurrent chemotherapy (CCRT) remains unclear. Study Design Retrospective review. Methods Clinical characteristics of OPSCC patients treated between 2008 and 2015 with CCRT were abstracted from medical records. OS curves and multivariate cox proportional hazard ratios (HRs) were examined. Results Of 120 evaluable patients, 71% had HPV+ tumors. Median follow-up duration for the entire cohort was 41.5 months (ra… περισσότερα » In reference to Spontaneous middle cranial fossa cerebrospinal fluid otorrhea in adults Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 52 δευτερόλεπτα [image: cover.gif?v=1&s=fdf3bf895114aa3ba0986593] from #ORL via xlomafota13 on Inoreader http://ift.tt/28VmWsF via IFTTT περισσότερα » The evolution of combined molecular targeted therapies to advance the therapeutic efficacy in melanoma: a highlight of vemurafenib and cobimetinib Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 53 δευτερόλεπτα [image: 88x31.png] from Melanoma via xlomafota13 on Inoreader http://ift.tt/293H7dA περισσότερα » Pharmacological preconditioning for short-term ex vivo expansion of human umbilical cord blood hematopoietic stem cells by filgrastim. Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα Related Articles *Pharmacological preconditioning for short-term ex vivo expansion of human umbilical cord blood hematopoietic stem cells by filgrastim.* Am J Stem Cells. 2016;5(1):29-38 Authors: Grigoriadis NG, Grigoriadis IG, Markoula S, Paschopoulos M, Zikopoulos K, Apostolakopoulos PG, Vizirianakis IS, Georgiou I Abstract Although umbilical cord blood (UCB) hematopoietic stem cell transplantation (UCBT) has emerged as a promising haematological reconstitution therapy for leukemias and other related disorders, the insufficient UCB stem cell dosage still hinders better clinical … περισσότερα » Induction of sensory neurons from neuroepithelial stem cells by the ISX9 small molecule. Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα Related Articles *Induction of sensory neurons from neuroepithelial stem cells by the ISX9 small molecule.* Am J Stem Cells. 2016;5(1):19-28 Authors: Ali RQ, Blomberg E, Falk A, Ährlund-Richter L, Ulfendahl M Abstract Hearing impairment most often involves loss of sensory hair cells and auditory neurons. As this loss is permanent in humans, a cell therapy approach has been suggested to replace damaged cells. It is thus of interest to generate lineage restricted progenitor cells appropriate for cell based therapies. Human long-term self-renewing neuroepithelial stem (lt-NES) cell … περισσότερα » Influence of paternal preconception exposures on their offspring: through epigenetics to phenotype. Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα Related Articles *Influence of paternal preconception exposures on their offspring: through epigenetics to phenotype.* Am J Stem Cells. 2016;5(1):11-8 Authors: Day J, Savani S, Krempley BD, Nguyen M, Kitlinska JB Abstract Historically, research into congenital defects has focused on maternal impacts on the fetal genome during gestation and prenatal periods. However, recent findings have sparked interest in epigenetic alterations of paternal genomes and its effects on offspring. This emergent field focuses on how environmental influences can epigenetically alter gene expression and… περισσότερα » Comparison of stem cell therapies for acute kidney injury. Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα Related Articles *Comparison of stem cell therapies for acute kidney injury.* Am J Stem Cells. 2016;5(1):1-10 Authors: Barnes CJ, Distaso CT, Spitz KM, Verdun VA, Haramati A Abstract Acute kidney injury (AKI) is the rapid onset of decreased kidney function that ultimately increases mortality and morbidity. Stem cell research is a promising avenue for curative and preventative therapies of kidney injury, however, there are many types of stem cells under investigation. Currently there is no research to compare the value of one stem cell method over another. Induced pluripotent stem … περισσότερα » Pharmacological preconditioning for short-term ex vivo expansion of human umbilical cord blood hematopoietic stem cells by filgrastim. Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα Related Articles *Pharmacological preconditioning for short-term ex vivo expansion of human umbilical cord blood hematopoietic stem cells by filgrastim.* Am J Stem Cells. 2016;5(1):29-38 Authors: Grigoriadis NG, Grigoriadis IG, Markoula S, Paschopoulos M, Zikopoulos K, Apostolakopoulos PG, Vizirianakis IS, Georgiou I Abstract Although umbilical cord blood (UCB) hematopoietic stem cell transplantation (UCBT) has emerged as a promising haematological reconstitution therapy for leukemias and other related disorders, the insufficient UCB stem cell dosage still hinders better clinical … περισσότερα » Influence of paternal preconception exposures on their offspring: through epigenetics to phenotype. Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα Related Articles *Influence of paternal preconception exposures on their offspring: through epigenetics to phenotype.* Am J Stem Cells. 2016;5(1):11-8 Authors: Day J, Savani S, Krempley BD, Nguyen M, Kitlinska JB Abstract Historically, research into congenital defects has focused on maternal impacts on the fetal genome during gestation and prenatal periods. However, recent findings have sparked interest in epigenetic alterations of paternal genomes and its effects on offspring. This emergent field focuses on how environmental influences can epigenetically alter gene expression and… περισσότερα » Induction of sensory neurons from neuroepithelial stem cells by the ISX9 small molecule. Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα Related Articles *Induction of sensory neurons from neuroepithelial stem cells by the ISX9 small molecule.* Am J Stem Cells. 2016;5(1):19-28 Authors: Ali RQ, Blomberg E, Falk A, Ährlund-Richter L, Ulfendahl M Abstract Hearing impairment most often involves loss of sensory hair cells and auditory neurons. As this loss is permanent in humans, a cell therapy approach has been suggested to replace damaged cells. It is thus of interest to generate lineage restricted progenitor cells appropriate for cell based therapies. Human long-term self-renewing neuroepithelial stem (lt-NES) cell … περισσότερα » Comparison of stem cell therapies for acute kidney injury. Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα Related Articles *Comparison of stem cell therapies for acute kidney injury.* Am J Stem Cells. 2016;5(1):1-10 Authors: Barnes CJ, Distaso CT, Spitz KM, Verdun VA, Haramati A Abstract Acute kidney injury (AKI) is the rapid onset of decreased kidney function that ultimately increases mortality and morbidity. Stem cell research is a promising avenue for curative and preventative therapies of kidney injury, however, there are many types of stem cells under investigation. Currently there is no research to compare the value of one stem cell method over another. Induced pluripotent stem … περισσότερα » Fibrous Dysplasia of the Temporal Bone Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα with External Auditory Canal Stenosis and Secondary Cholesteatoma Yu-Hsi Liu 1 , Kuo-Ping Chang 1 1 Department of Otorhinolaryngology – Head and Neck Surgery, Kaohsiung Veterans General Hospital, Kaohsiung City, Thaiwan, Province of China J Int Adv Otol 2016; 12: 125-128 DOI: 10.5152/iao.2016.1381 Abstract Fibrous dysplasia is a slowly progressive benign fibro-osseous disease, rarely occurring in temporal bones. In these cases, most bony lesions developed from the bony part of the external auditory canals, causing otalgia, hearing impairment, otorrhea, and ear hygiene blockade … περισσότερα » Syringocystadenomapapilliferum Arising from the External Auditory Canal Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα : A Rare Tumor in a Rare Site Hazem M. Abdel Tawab 1 , Khalid F. Amish 2 , Ibrahim A. Sulaiman 3 , Rubyath C. Rajib 3 1 Department of Otorhinolaryngology, Cairo University School of Medicine, Cairo, Egypt; Department of Otorhinolaryngology, Sultan Qaboos Hospital, Salalah, Oman 2 Department of Otorhinolaryngology, Sultan Qaboos Hospital, Salalah, Oman. 3 Department of Pathology, Sultan Qaboos Hospital, Salalah, Oman J Int Adv Otol 2016; 12: 116-118 DOI: 10.5152/iao.2016.2036 Abstract Syringocystadenomapapilliferum is an extremely rare benign adnexal tumor of the scalp an… περισσότερα » Anterior Displacement of the Geniculate Ganglion Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα Tomoyasu Tachibana 1 , Yorihisa Orita 2 , Kazunori Nishizaki 2 1 Clinic of Otolaryngology, Himeji Red Cross Hospital, Himeji, Japan 2 Department of Otolaryngology, Okayama University School of Medicine, Okayama, Japan J Int Adv Otol 2016; 12: 113-115 DOI: 10.5152/iao.2016.1559 Abstract We present the case of a 34-year-old Japanese woman with cholesteatoma of the middle ear. During the operation, this patient showed an unusual position of the geniculate ganglion. We reviewed the computed tomography (CT) images targeting the ear of the present case after the operation. We fo… περισσότερα » Cochlear Implantation Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα Alternative Techniques in Özgür Sürmelioğlu 1 , Süleyman Özdemir 1 , Özgür Tarkan 1 , Ülkü Tuncer 1 , Fikret Çetik 1 , Karahan Kara 1 , Mete Kıroğlu 1 J Int Adv Otol 2016; 12: 109-112 DOI: 10.5152/iao.2015.1022 Abstract *OBJECTIVE*: To review the alternative techniques in cochlear implantation and to compare the complications with different techniques. *MATERIALS and METHODS*: Patients who had undergone cochlear implantation were reviewed. Those patients who were operated using alternative techniques were selected and evaluated for the cause of their hearing loss and f… περισσότερα » Eustachian Tube Dysfunction Questionnaire Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα Responsiveness of the 7-item Shari Van Roeyen 1 , Paul Van de Heyning 1 , Vincent Van Rompaey 1 1 Antwerp University Hospital, Otorhinolaryngology and Head and Neck Surgery, Edegem, Belgium; University of Antwerp, School of Medicine and Health Sciences, Wilrijk, Belgium J Int Adv Otol 2016; 12: 106-108 DOI: 10.5152/iao.2016.2086 Abstract *OBJECTIVE*: Baro-challenge-induced Eustachian tube (ET) dysfunction is defined as the presence of aural discomfort, popping, or pain, which only arises in case of ambient pressure changes, without abnormalities on otoscopy or tympanometry. … περισσότερα » Oxidative Stress and Inflammatory Mediators in Benign Paroxysmal Positional Vertigo Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα The Role of Mehmet Taylan Güçlütürk 1 , Zeynep Nil Ünal 2 , Onur İsmi 1 , Mehmet Burak Yavuz Çimen 3 , Murat Ünal 1 1 Department of Otorhinolaryngology, Mersin University School of Medicine, Mersin, Turkey 2 Department of Biochemistry, Mersin University School of Medicine, Mersin, Turkey 3 Department of Medical Biochemistry, Mersin University School of Medicine, Mersin, Turkey J Int Adv Otol 2016; 12: 101-105 DOI: 10.5152/iao.2015.1412 Abstract *OBJECTIVE*: Benign paroxysmal positional vertigo (BPPV) is the most common peripheral cause of vertigo. It can be defined as… περισσότερα » Asymmetrical Audiovestibular Symptoms Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα The Agreement between Protocols for the Investigation of Robert Nash 1 , Anooj Majithia 1 , Arvind Singh 1 1 Department of Otolaryngology, Head and Neck Surgery, Northwick Park Hospital, London, United Kingdom J Int Adv Otol 2016; 12: 98-100 DOI: 10.5152/iao.2016.1581 Abstract *OBJECTIVE*: There are a number of published criteria for the investigation of asymmetrical audiovestibular symptoms. Our aim was to determine the agreement between these protocols when determining whether to investigate a group of patients treated at our institution. *MATERIALS and METHODS*: Retrospec… περισσότερα » Vertigo Spells Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα Response Over Time of Vertigo Spells to Intratympanic Dexamethasone Treatment in Meniere’s Disease Patients Nabil Atrache Al Attrache 1 , Claudio Krstulovic 1 , Vanesa Pérez Guillen 1 , Constantino Morera Pérez 1 , Herminio Pérez Garrigues 1 J Int Adv Otol 2016; 12: 92-97 DOI: 10.5152/iao.2016.2177 Abstract *OBJECTIVE*: To assess the effectiveness and response over time of intratympanic dexamethasone on the symptoms of Meniere’s disease. *MATERIALS and METHODS*: We performed a matched cohort study of 24 patients with Meniere’s disease who were unresponsive to initial treatme… περισσότερα » Increased Velocity Storage in Subjects with Meniere’s Disease Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα Claudio Krstulovic 1 , Nabil Atrache Al Attrache 1 , Herminio Pérez Garrigues 2 , Herminia Argente-Escrig 3 , Luis Bataller Alberola 3 , Constantino Morera Pérez 2 1 Department of Otolaryngology, Hospital Universitario y Politécnico La Fe, Valencia, Spain. 2 Department of Otolaryngology, Hospital Universitario La Fe, Valencia, Spain. 3 Department of Neurology, Hospital Universitario y Politécnico La Fe, Valencia, Spain J Int Adv Otol 2016; 12: 87-91 DOI: 10.5152/iao.2016.1947 Abstract *OBJECTIVE*: Velocity storage mechanism is a multisensory rotation estimator; it c… περισσότερα » Wideband Tympanometry Normative Data for Different Age Groups Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα in Turkish Population Abdulkadir Özgür 1 , Banu Müjdeci 2 , Suat Terzi 1 , Zerrin Özergin Coşkun 1 , Enes Yiğit 1 , Engin Dursun 1 1 Department of Otorhinolaryngology, Recep Tayyip Erdoğan University School of Medicine, Rize, Turkey 2 Department of Audiology, Yıldırım Beyazıt University Institute of Health Sciences, Ankara, Turkey J Int Adv Otol 2016; 12: 82-86 DOI: 10.5152/iao.2015.1408 Abstract *OBJECTIVE*: Studies on the use of wideband tympanometry (WBT) for the evaluation of middle ear pathologies have been increasing gradually in recent years. However, studies r… περισσότερα » Severe Chronic Tinnitus : Angiotensin-Converting Enzyme (ACE) I/D and Alpha-Adducin (ADD1) G460W Gene Polymorphisms Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα in Turkish Patients with Severe Chronic Tinnitus Salim Yüce 1 , Enver Sancakdar 2 , Gökhan Bağcı 3 , Sema Koç 4 , Hande Küçük Kurtulgan 3 , Binnur Bağcı 5 , Mansur Doğan 1 , İsmail Önder Uysal 1 1 Department of Otorhinolaryngology, Cumhuriyet University School of Medicine, Sivas, Turkey. 2 Department of Biochemistry, Cumhuriyet University School of Medicine, Sivas, Turkey 3 Department of Medical Genetics, Cumhuriyet University School of Medicine, Sivas, Turkey 4 Department of Ear Nose Throat Head and Neck Surgery, Antalya Training and Research Hospital, Antalya, … περισσότερα » Tinnitus Retraining Therapy Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα in Unilateral Tinnitus Patients with Single Side Deafness Sang Hoon Kim 1 , Jae Yong Byun 1 , Seung Geun Yeo 1 , Moon Suh Park 1 1 Department of Otorhinolaryngology, Kyung Hee University Graduate School, Seoul, Korea J Int Adv Otol 2016; 12: 72-76 DOI: 10.5152/iao.2016.1949 Abstract *OBJECTIVE*: The purpose of this study was to evaluate the audiologic and clinical characteristics of the tinnitus in single-sided deafness (SSD) patients and to determine whether tinnitus retraining therapy (TRT) is beneficial to those patients who suffer from tinnitus with SSD. *MATERIALS and… περισσότερα » Intensity on the Speech Evoked Auditory Late Latency Response Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα The Effect of Intensity on the Speech Evoked Auditory Late Latency Response in Normal Hearing Individuals Hari Prakash 1 , Aju Abraham 1 , Bellur Rajashekar 1 , Krishna Yerraguntla 1 1 Department of Speech and Hearing, School of Allied Health Science, Karnataka, India J Int Adv Otol 2016; 12: 67-71 DOI: 10.5152/iao.2016.1776 Abstract *OBJECTIVE*: Among the stimulus factors, the influence of presentation level is less studied in normal-hearing individuals when using speech stimuli withvarious presentation levels for the auditory late latency response (ALLR). Hence, the prese… περισσότερα » Smartphone Based Audiometric Test Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα for Confirming the Level of Hearing; Is It Useable in Underserved Areas? Levent Renda 1 , Ömer Tarık Selçuk 1 , Hülya Eyigör 1 , Üstün Osma 1 , Mustafa Deniz Yılmaz 1 1 Department of Ear Nose and Throat, Antalya Training and Research Hospital, Antalya, Turkey J Int Adv Otol 2016; 12: 61-66 DOI: 10.5152/iao.2016.1421 Abstract *OBJECTIVE*: To determine the hearing levels of participants of a randomized group using a smartphone hearing application and to compare these results with the results from a pure-tone audiogram. *MATERIALS and METHODS*: A heterogenous group consistin… περισσότερα » Hearing Screening Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα Follow-Up Results of Newborns after Hearing Screening at a Training and Research Hospital in Turkey Rasim Yılmazer 1 , Mine Zahide Yazıcı 2 , İbrahim Erdim 2 , Hakan Kamil Kaya 2 , Şengül Özcan Dalbudak 2 , Tülin Fatma Kayhan 2 1 Department of Otolaryngology-Head and Neck Surgery, University of Miami Miller School of Medicine, Miami, FL, USA; Department of Otolaryngology-Head and Neck Surgery, İstanbul Medipol University, İstanbul, Turkey 2 Department of Otorhinolaryngology, Bakırköy Dr. Sadi Konuk Training and Research Hospital, İstanbul, Turkey J Int Adv Otol 2016; 1… περισσότερα » Hearing Loss in Persons Exposed and not Exposed to Occupational Noise Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα Martina Kovalova 1 , Eva Mrazkova 1 , Petra Sachova 2 , Kristyna Vojkovska 3 , Hana Tomaskova 1 , Jana Janoutova 1 , Vladimir Janout 1 1 Department of Epidemiology and Public Health, University of Ostrava Faculty of Medicine, Ostrava, Czech Republic 2 Department of Preventive Medicine, Palacký University Olomouc, Faculty of Medicine and Dentistry, Olomouc, Czech Republic 3 Center for Hearing and Balance Disorders, Ostrava, Czech Republic J Int Adv Otol 2016; 12: 49-54 DOI: 10.5152/iao.2016.1770 Abstract *OBJECTIVE*: This study aimed to compare hearing loss in indivi… περισσότερα » Radiological Imaging Findings of Patients with Congenital Totally Hearing Loss Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα Muhammed Dağkıran 1 , Nermin Dağkıran 2 , Özgür Sürmelioğlu 1 , Tuğsan Ballı 2 , Ülkü Tuncer 1 , Erol Akgül 2 , Fikret Çetik 1 1 Department of Otorhinolaryngology, Çukurova University School of Medicine, Adana, Turkey 2 Department of Radiology, Çukurova University School of Medicine, Adana, Turkey J Int Adv Otol 2016; 12: 43-48 DOI: 10.5152/iao.2015.1450 Abstract OBJECTIVE: The aim of this study was to determine and classify inner ear abnormalities in patients who had cochlear implants because of congenital sensorineural hearing loss using preoperative temporal bone com… περισσότερα » Development of Hemolytic Anemia in a Nivolumab-Treated Patient with Refractory Metastatic Squamous Cell Skin Cancer and Chronic Lymphatic Leukemia medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα 
Management of patients with metastatic squamous cell skin cancer, refractory to initial therapy with standard chemotherapy and radiation protocols, remains difficult with poor overall prognosis and limited therapeutic options. Recently, promising response rates with nivolumab, a programmed death receptor-1-blocking antibody, in squamous cancer of the head and neck have been demonstrated. Considering the similar histological […] περισσότερα » A Giant Retroperitoneal Liposarcoma Encasing the Entire Left Kidney and Adherent to Adjacent Structures: A Case Report medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα 
Retroperitoneal liposarcoma is a rare tumor. The dimension and weight of liposarcoma are variable; those over 20 kg are called ‘giant liposarcoma’. Herein, we report giant retroperitoneal liposarcoma measuring 45 cm in diameter and 25 kg in weight encasing the entire left kidney and adherent to adjacent structures. A 71-year-old woman presented for a regular […] περισσότερα » Pazopanib in Primary Cardiac Angiosarcoma of the Right Atrium: A Case Report medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα 
Primary heart tumors are an extremely rare oncological entity with primary cardiac sarcomas usually representing 20% of all primary cardiac tumorous lesions [Shanmugam: Eur J Cardiothorac Surg 2006;29: 925–932; Orlandi et al.: J Thorac Oncol 2010;5: 1483–1489]. Angiosarcoma is the most prevalent histology and despite a multidisciplinary approach tends to have a dismal prognosis [Shanmugam: […]from Medicine by Alexandros G. Sfakianakis http://ift.tt/294FdYA
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Diagnostic dilemmas of high grade transformation (Richter’s syndrome) of chronic lymphocytic leukaemia: results of the phase II NCRI CHOP-OR clinical trial specialist haemato-pathology central review Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα Abstract Aims Richter’s syndrome refers to high grade transformation of B-cell chronic lymphocytic leukaemia (CLL), usually to diffuse large B-cell lymphoma (DLBCL), as assessed by strict World Health Organisation (WHO)-defined histological criteria. Although a relatively evidence-poor area, the recommended clinical management of high grade transformation differs considerably from relapsed CLL. The ‘CHOP-OR’ trial was a single arm, multi-centre, non-randomised phase II NCRI trial in patients with newly diagnosed Richter’s syndrome, recruiting from across the UK from April 2011 to… περισσότερα » Classification of TP53 mutations and HPV predict survival in advanced larynx cancer Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα [image: cover.gif?v=1&s=fdf3bf895114aa3ba0986593] Objectives/Hypothesis Assess tumor suppressor p53 (*TP53*) functional mutations in the context of other biomarkers in advanced larynx cancer. Study Design Prospective analysis of pretreatment tumor *TP53*, human papillomavirus (HPV), Bcl-xL, and cyclin D1 status in stage III and IV larynx cancer patients in a clinical trial. Methods *TP53* exons 4 through 9 from 58 tumors were sequenced. Mutations were grouped using three classifications based on their expected function. Each functional group was analyzed for response to induction … περισσότερα » Singing voice outcomes following singing voice therapy Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα [image: cover.gif?v=1&s=fdf3bf895114aa3ba0986593] Objectives/Hypothesis The objectives of this study were to describe singing voice therapy (SVT), describe referred patient characteristics, and document the outcomes of SVT. Study Design Retrospective. Methods Records of patients receiving SVT between June 2008 and June 2013 were reviewed (n = 51). All diagnoses were included. Demographic information, number of SVT sessions, and symptom severity were retrieved from the medical record. Symptom severity was measured via the 10-item Singing Voice Handicap Index (SVHI-10). Treatment ou… περισσότερα » Smoking cessation is associated with improved survival in oropharynx cancer treated by chemoradiation Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα Objectives/Hypothesis The effect of smoking and human papillomavirus (HPV) on overall survival (OS) of oropharyngeal squamous cell carcinoma (OPSCC) patients undergoing concurrent chemotherapy (CCRT) remains unclear. Study Design Retrospective review. Methods Clinical characteristics of OPSCC patients treated between 2008 and 2015 with CCRT were abstracted from medical records. OS curves and multivariate cox proportional hazard ratios (HRs) were examined. Results Of 120 evaluable patients, 71% had HPV+ tumors. Median follow-up duration for the entire cohort was 41.5 months (range =… περισσότερα » In reference to Spontaneous middle cranial fossa cerebrospinal fluid otorrhea in adults Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα [image: cover.gif?v=1&s=fdf3bf895114aa3ba0986593] from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/28VmWsF via IFTTT περισσότερα » Age-associated decrease in GDNF and its cognate receptor GFRα-1 protein expression in human skin Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα Summary Glial cell line-derived neurotrophic factor (GDNF) and its cognate receptor (GFRα-1) are expressed in normal human skin. They are involved in murine hair follicle morphogenesis and cycling control. We hypothesize that ‘GDNF and GFRα-1 protein expression in human skin undergoes age-associated alterations. To test our hypothesis, the expression of these proteins was examined in human skin specimens obtained from 30 healthy individuals representing three age groups: children (5–18 years), adults (19–60 years) and the elderly (61–81 years). Immunofluorescent and light microscopi… περισσότερα » Identification of a Forensically and Medically Important Blowfly: A Case Study of Adult Calliphora vicina (Rob-Desvoidy) in TurkeyIdentification of Adult Calliphora vicina Alexandros G. SfakianakisστοΝοσολογίαΠριν από 25 δευτερόλεπτα 2016-06-27T03-13-27Z *Source:* European Journal of Forensic Sciences Halide Nihal ACIKGOZ, Duygu DIVRAK, Meriem TALEB. Background: Blowflies are a group of species which belong to Calliphoridae family, and they often colonize human and animal corpses. Being the first species to settle on cadavers, they have become of great forensic importance. They lay their eggs on corpses and play a crucial role in the decomposition process. Many species of blowflies appear globally while some of them live in certain regions. Calliphora vicina (Robineau-Desvoidy, 1830) (Diptera, Calliphoridae) is a … περισσότερα » Functional Role of Milk Fat Globule-Epidermal Growth Factor VIII in Macrophage-Mediated Inflammatory Responses and Inflammatory/Autoimmune Diseases Alexandros G. SfakianakisστοΝοσολογίαΠριν από 25 δευτερόλεπτα Inflammation involves a series of complex biological processes mediated by innate immunity for host defense against pathogen infection. Chronic inflammation is considered to be one of the major causes of serious diseases, including a number of autoimmune/inflammatory diseases, cancers, cardiovascular diseases, and neurological diseases. Milk fat globule-epidermal growth factor 8 (MFG-E8) is a secreted protein found in vertebrates and was initially discovered as a critical component of the milk fat globule. Previously, a number of studies have reported that MFG-E8 contributes to vari… περισσότερα » Characterization of the Blood Brain Barrier in Pediatric Central Nervous System Neoplasms Alexandros G. SfakianakisστοΝοσολογίαΠριν από 25 δευτερόλεπτα 2016-06-27T01-48-02Z *Source:* Journal of Interdisciplinary Histopathology Christopher S Hong, Winson Ho, Martin G Piazza, Abhik Ray-Chaudhury, Zhengping Zhuang, John D Heiss. Objective: The normal bloodbrain barrier (BBB) is composed of tight junctions between endothelial cells and surrounding astrocyte foot processes. Breakdown of the physiological astrocyte-endothelial cell relationship occurs in adult metastatic and primary brain tumors. However, the astrocyte-endothelial cell relationship has not been studied in pediatric tumors. Materials and Methods: Utilizing specimens from ca… περισσότερα » Transoral robotic base of tongue reduction for obstructive sleep apnea Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 25 δευτερόλεπτα
A systematic review and meta-analysis: [image: cover.gif?v=1&s=fdf3bf895114aa3ba0986593] Objectives/Hypothesis To determine the effect of transoral robotic surgery (TORS) base of tongue (BOT) reduction on sleep-related outcomes in patients with obstructive sleep apnea (OSA). Data Sources PubMed, Scopus, EMBASE, CINAHL, Cochrane, and Ovid. Review Methods Literature search by two independent authors was conducted using the abovementioned databases. Studies on TORS BOT reduction as part of OSA treatment in adult patients with pre- and postoperative apnea–hypopnea index (AHI) scores … περισσότερα » Cochlear implantation for single-sided deafness Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 25 δευτερόλεπτα A multicenter study: [image: cover.gif?v=1&s=fdf3bf895114aa3ba0986593] Objectives/Hypothesis To report the preliminary outcomes of patients with single-sided deafness and asymmetric hearing loss undergoing cochlear implantation at two centers. Study Design Retrospective review and prospective data collection. Methods Patients with single-sided deafness who underwent cochlear implantation at two centers were included. Pre- and postoperative measures included monosyllabic word and sentence recognition in quiet for the ear implanted, and sentence recognition in noise in the best-aide… περισσότερα » Midline posterior glossectomy and LT are beneficial in normal weight and overweight children with DS who have persistent OSA following TA and are intolerant of PAP therapy Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 25 δευτερόλεπτα Midline posterior glossectomy and lingual tonsillectomy in obese and nonobese children with down syndrome: Biomarkers for success: Objectives/Hypothesis To examine outcomes following midline posterior glossectomy (MPG) plus lingual tonsillectomy (LT) for the treatment of significant obstructive sleep apnea (OSA) in children with Down syndrome (DS). Methods Patients with DS who had persistent OSA following tonsillectomy and adenoidectomy (TA) and were relatively intolerant of positive airway pressure (PAP) therapy were evaluated by physical examination and sleep/CINE magnetic resonan… περισσότερα » Use of a NIM system to identify the functional separation between inclusion and exclusion branches of the hypoglossal nerve for implantation of a selective upper-airway stimulation system. Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 25 δευτερόλεπτα Nerve monitoring-guided selective hypoglossal nerve stimulation in obstructive sleep apnea patients: [image: cover.gif?v=1&s=fdf3bf895114aa3ba0986593] Objective/Hypothesis Selective stimulation of the upper airway is a new therapy for obstructive sleep apnea. The aim of the study was to determine if a selective nerve integrity monitoring (NIM) system could aid in precise placement of the cuff electrode in selective upper-airway stimulation. Study Design Single-center, prospective clinical trial. Methods Twenty patients who received a selective upper-airway stimulation system (Ins… περισσότερα » Neuroendocrine Adenoma of the Middle Ear Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 25 δευτερόλεπτα A Rare Histopathological Diagnosis: Neuroendocrine tumours occur throughout the body but are rare in the head and neck region and particularly rare in the middle ear. Clinical findings are often nonspecific and therefore pose a diagnostic challenge. Furthermore, the nomenclature of neuroendocrine tumours of the middle ear is historically controversial. Herein a case is presented of a middle ear adenoma in a 33-year-old patient who presented with otalgia, hearing loss, and facial nerve palsy. A brief discussion is included regarding the histopathological features of middle ear adeno… περισσότερα » Chirp Stimuli in ABR/ASSR Measurement Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 25 δευτερόλεπτα Update on Auditory Evoked Responses: Value of Chirp Stimuli in ABR/ASSR Measurement: When I first heard about chirps many years ago, none of the clinical ABR systems had chirps as stimuli. As time went on, some of the manufacturers began to introduce chirps. As with any other new development, they were heavily promoted. However, I was not going to start using a new type of stimulus when the existing stimuli - traditional tone bursts and clicks - worked just fine. I kept an open mind, but I looked for evidence. Today, there is plenty of evidence for the use of chirps. περισσότερα » OtoRhinoLaryngology Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 25 δευτερόλεπτα 11m OtoRhinoLaryngology - Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader Neuroendocrine Adenoma of the Middle Ear: A Rare Histopathological Diagnosis Neuroendocrine tumours occur throughout the body but are rare in the head and neck region and particularly rare in the middle ear. Clinical findings are often nonspecific and therefore pose a diagnostic challenge. Furthermore, the nomenclature of neuroendocrine tumours of the middle ear is historically… 1h OtoRhinoLaryngology - Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader Nerve monitoring… περισσότερα » Head and Neck on PubMed Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 25 δευτερόλεπτα - Pharmacological preconditioning for short-term ex vivo expansion of human umbilical cord blood hematopoietic stem cells by filgrastim.Grigoriadis NG, Grigoriadis IG, Markoula S, Paschopoulos M, Zikopoulos K, Apostolakopoulos PG, Vizirianakis IS, Georgiou I, 2016-06-27 11:28:25 AM Related Articles *Pharmacological preconditioning for short-term ex vivo expansion of human umbilical cord blood hematopoietic stem cells by filgrastim.* Am J Stem Cells. 2016;5(1):29-38 Authors: Grigoriadis NG, Grigoriadis IG, Markoula S, Paschopoulos M, Zikopoulos K, Aposto… περισσότερα » Head and Neck on PubMed Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 25 δευτερόλεπτα *Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates Pharmacological preconditioning for short-term ex vivo expansion of human umbilical cord blood hematopoietic stem cells by filgrastim. Today, 27 Ιουνίου 2016, 3 hours ago | Grigoriadis NG, Grigoriadis IG, Markoula S, Paschopoulos M, Zikopoulos K, Apostolakopoulos PG, Vizirianakis IS, Georgiou I[image: Go to full article] Related Articles*Pharmacological preconditioning for short-term ex vivo expansion of human umbilical cord blood hematopoietic stem cel… περισσότερα » Exploration of the Dietary and Lifestyle Behaviors and Weight Status and Their Self-Perceptions among Health Sciences University Students in North Lebanon Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 29 δευτερόλεπτα University students may experience significant environmental changes that exert a negative influence on the quality of their diet and lifestyle. There is scarcity of data concerning the dietary and lifestyle behaviors and weight status of students in the health field in North Lebanon. To investigate these data, a cross-sectional survey was conducted including 369 health sciences students aged 18–25 chosen from four public and private universities in North Lebanon. Data were collected using a standardized interview questionnaire to determine sociodemographic, dietary, and lifestyle… περισσότερα » Pharmaceuticals, Vol. 9, Pages 36: Site-Specific Labeling of Protein Kinase CK2: Combining Surface Display and Click Chemistry for Drug Discovery Applications Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 29 δευτερόλεπτα Human CK2 is a heterotetrameric constitutively active serine/threonine protein kinase and is an emerging target in current anti-cancer drug discovery. The kinase is composed of two catalytic CK2α subunits and two regulatory CK2β subunits. In order to establish an assay to identify protein-protein-interaction inhibitors (PPI) of the CK2α/CK2β interface, a bioorthogonal click reaction was used to modify the protein kinase α-subunit with a fluorophore. By expanding the genetic code, the unnatural amino acid para azidophenylalanine (pAzF) could be incorporated into CK2α. Performing th… περισσότερα » Materials, Vol. 9, Pages 520: Curcumin and Osteosarcoma: Can Invertible Polymeric Micelles Help? Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα Systematic review of experimental and clinical data on the use of curcumin in the treatment of osteosarcoma is presented. The current status of curcumin’s therapeutic potential against bone cancer is analyzed in regard to using polymeric micelles (including recently developed invertible, responsive, micelles) as a platform for curcumin delivery to treat osteosarcoma. The potential of micellar assemblies from responsive macromolecules in a controlled delivery of curcumin to osteosarcoma cells, and the release using a new inversion mechanism is revealed. from #Medicine via ola Kala … περισσότερα » Sports, Vol. 4, Pages 36: Differences in Spatial Physical Activity Patterns between Weekdays and Weekends in Primary School Children: A Cross-Sectional Study Using Accelerometry and Global Positioning System Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα Targeting the weekend to promote physical activity (PA) in children seems to be promising given that they tend to be less physically active and, particularly, as the age-related decline in PA is more marked during weekends. Considering the ambiguity of why children are not able to maintain their PA level on weekends, the aim of the present study was to objectively investigate differences in children’s spatial PA patterns between week and weekend days using the combination of Global Positioning System (GPS) and accelerometry. Seventy-four second graders (aged 7–9 years) and 98 sixt… περισσότερα » Sensors, Vol. 16, Pages 980: On Curating Multimodal Sensory Data for Health and Wellness Platforms Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα In recent years, the focus of healthcare and wellness technologies has shown a significant shift towards personal vital signs devices. The technology has evolved from smartphone-based wellness applications to fitness bands and smartwatches. The novelty of these devices is the accumulation of activity data as their users go about their daily life routine. However, these implementations are device specific and lack the ability to incorporate multimodal data sources. Data accumulated in their usage does not offer rich contextual information that is adequate for providing a holistic v… περισσότερα » Cells, Vol. 5, Pages 29: Epithelial Intermediate Filaments: Guardians against Microbial Infection? Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα Intermediate filaments are abundant cytoskeletal components of epithelial tissues. They have been implicated in overall stress protection. A hitherto poorly investigated area of research is the function of intermediate filaments as a barrier to microbial infection. This review summarizes the accumulating knowledge about this interaction. It first emphasizes the unique spatial organization of the keratin intermediate filament cytoskeleton in different epithelial tissues to protect the organism against microbial insults. We then present examples of direct interaction between viral, … περισσότερα » Photonics, Vol. 3, Pages 41: Engineering Multi-Section Quantum Cascade Lasers for Broadband Tuning Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα In an effort to overcome current limitations to electrical tuning of quantum cascade lasers, a strategy is proposed which combines heterogeneous quantum cascade laser gain engineering with sampled grating architectures. This approach seeks to not only widen the accessible spectral range for an individual emitter, but also compensate for functional non-uniformity of reflectivity and gain lineshapes. A trial laser with a dual wavelength core is presented which exhibits electroluminescence over a 750 cm−1 range and discrete single mode laser emission over a 700 cm−1 range. Electrical … περισσότερα » Energies, Vol. 9, Pages 491: Frequency-Splitting-Free Synchronous Tuning of Close-Coupling Self-Oscillating Wireless Power Transfer Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα The synchronous tuning of the self-oscillating wireless power transfer (WPT) in a close-coupling condition is studied in this paper. The Hamel locus is applied to predict the self-oscillating points in the WPT system. In order to make the system operate stably at the most efficient point, which is the middle resonant point when there are middle resonant and split frequency points caused by frequency-splitting, the receiver (RX) rather than the transmitter (TX) current is chosen as the self-oscillating feedback variable. The automatic delay compensation is put forward to eliminate … περισσότερα » Land, Vol. 5, Pages 21: Agriculture on the Brink: Climate Change, Labor and Smallholder Farming in Botswana Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα Botswana is a semi-arid, middle-income African country that imports 90 percent of its food. Despite its relative prosperity, Botswana also suffers from one of the highest measures of income inequality in the world, persistent poverty, and relatively high levels of food insecurity. The objective of this paper is to explore how political economy, climate change and livelihood dynamics are synergistically impacting household food security. The major finding is that the marginalization of smallholder farming in Botswana has as much or more to do with domestic, regional and internation… περισσότερα » Horticulturae, Vol. 2, Pages 7: An Overview of Fertilization and Irrigation Management in the Conventional and Certified Organic Production of Vegetable Crops in Florida Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα The postharvest quality of vegetable crops from conventional and organic production systems depends on pre-harvest factors such as variety genetic potential, fertilization, and irrigation. The five principles of plant nutrition (plants absorb ions, not fertilizers; Leibeig’s law of the minimum; nutrient application requires a source, a rate, a placement and a time of application; no correlation exists between total nutrient presence in the soil and availability; and plant nutrient concentration and yield are related) must be followed throughout the crop growth cycle. In certified … περισσότερα » Horticulturae, Vol. 2, Pages 6: Estimating the Leaf Area of Cut Roses in Different Growth Stages Using Image Processing and Allometrics Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα Non-destructive, accurate, user-friendly and low-cost approaches to determining crop leaf area (LA) are a key tool in many agronomic and physiological studies, as well as in current agricultural management. Although there are models that estimate cut rose LA in the literature, they are generally designed for a specific stage of the crop cycle, usually harvest. This study aimed to estimate the LA of cut “Red Naomi” rose stems in several phenological phases using morphological descriptors and allometric measurements derived from image processing. A statistical model was developed ba… περισσότερα » Energies, Vol. 9, Pages 492: Hybrid Modulation of Bidirectional Three-Phase Dual-Active-Bridge DC Converters for Electric Vehicles Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα Bidirectional power converters for electric vehicles (EVs) have received much attention recently, due to either grid-supporting requirements or emergent power supplies. This paper proposes a hybrid modulation of the three-phase dual-active bridge (3ΦDAB) converter for EV charging systems. The designed hybrid modulation allows the converter to switch its modulation between phase-shifted and trapezoidal modes to increase the conversion efficiency, even under light-load conditions. The mode transition is realized in a real-time manner according to the charging or discharging current…. περισσότερα » Peptide drugs accelerate BMP-2-induced calvarial bone regeneration and stimulate osteoblast differentiation through mTORC1 signaling Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα Both W9 and OP3-4 were known to bind the receptor activator of NF-κB ligand (RANKL), inhibiting osteoclastogenesis. Recently, both peptides were shown to stimulate osteoblast differentiation; however, the mechanism underlying the activity of these peptides remains to be clarified. A primary osteoblast culture showed that rapamycin, an mTORC1 inhibitor, which was recently demonstrated to be an important serine/threonine kinase for bone formation, inhibited the peptide-induced alkaline phosphatase activity. Furthermore, both peptides promoted the phosphorylation of Akt and S6K1, an … περισσότερα » Effect of Aurantii Fructus Immaturus Flavonoid on the Contraction of Isolated Gastric Smooth Muscle Strips in Rats Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα This study was designed to investigate the effect of Aurantii fructus immaturus flavonoid (AFIF) on the contraction of isolated gastric smooth muscle in rats and explore its underlying mechanisms. Isolated antral longitudinal smooth muscle strip (ALSMS) and pyloric circular smooth muscle strip (PCSMS) of rats were suspended in tissue chambers. The responses of ALSMS and PCSMS to administration of AFIF were observed. Cyclic guanosine monophosphate (cGMP) and protein kinase G (PKG) levels of PCSMS were measured by ELISA kits. In this study, AFIF showed no significant effect on ALSMS… περισσότερα » Antibacterial and Antibiofilm Activity of Methanolic Plant Extracts against Nosocomial Microorganisms Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 30 δευτερόλεπτα Biofilm is a complex microbial community highly resistant to antimicrobials. The formation of biofilms in biotic and abiotic surfaces is associated with high rates of morbidity and mortality in hospitalized patients. New alternatives for controlling infections have been proposed focusing on the therapeutic properties of medicinal plants and their antimicrobial effects. In the present study the antimicrobial and antibiofilm activities of 8 methanolic plant extracts were evaluated against clinical isolated microorganisms. Preliminary screening by diffusion well assay showed the anti… περισσότερα » Pharmacological preconditioning for short-term ex vivo expansion of human umbilical cord blood hematopoietic stem cells by filgrastim. Alexandros G. SfakianakisστοHead and NeckΠριν από 30 δευτερόλεπτα Related Articles *Pharmacological preconditioning for short-term ex vivo expansion of human umbilical cord blood hematopoietic stem cells by filgrastim.* Am J Stem Cells. 2016;5(1):29-38 Authors: Grigoriadis NG, Grigoriadis IG, Markoula S, Paschopoulos M, Zikopoulos K, Apostolakopoulos PG, Vizirianakis IS, Georgiou I Abstract Although umbilical cord blood (UCB) hematopoietic stem cell transplantation (UCBT) has emerged as a promising haematological reconstitution therapy for leukemias and other related disorders, the insufficient UCB stem cell dosage still hinders better clinical … περισσότερα » Induction of sensory neurons from neuroepithelial stem cells by the ISX9 small molecule. Alexandros G. SfakianakisστοHead and NeckΠριν από 30 δευτερόλεπτα Related Articles *Induction of sensory neurons from neuroepithelial stem cells by the ISX9 small molecule.* Am J Stem Cells. 2016;5(1):19-28 Authors: Ali RQ, Blomberg E, Falk A, Ährlund-Richter L, Ulfendahl M Abstract Hearing impairment most often involves loss of sensory hair cells and auditory neurons. As this loss is permanent in humans, a cell therapy approach has been suggested to replace damaged cells. It is thus of interest to generate lineage restricted progenitor cells appropriate for cell based therapies. Human long-term self-renewing neuroepithelial stem (lt-NES) cell … περισσότερα » Influence of paternal preconception exposures on their offspring: through epigenetics to phenotype. Alexandros G. SfakianakisστοHead and NeckΠριν από 30 δευτερόλεπτα Related Articles *Influence of paternal preconception exposures on their offspring: through epigenetics to phenotype.* Am J Stem Cells. 2016;5(1):11-8 Authors: Day J, Savani S, Krempley BD, Nguyen M, Kitlinska JB Abstract Historically, research into congenital defects has focused on maternal impacts on the fetal genome during gestation and prenatal periods. However, recent findings have sparked interest in epigenetic alterations of paternal genomes and its effects on offspring. This emergent field focuses on how environmental influences can epigenetically alter gene expression and… περισσότερα » Comparison of stem cell therapies for acute kidney injury. Alexandros G. SfakianakisστοHead and NeckΠριν από 30 δευτερόλεπτα Related Articles *Comparison of stem cell therapies for acute kidney injury.* Am J Stem Cells. 2016;5(1):1-10 Authors: Barnes CJ, Distaso CT, Spitz KM, Verdun VA, Haramati A Abstract Acute kidney injury (AKI) is the rapid onset of decreased kidney function that ultimately increases mortality and morbidity. Stem cell research is a promising avenue for curative and preventative therapies of kidney injury, however, there are many types of stem cells under investigation. Currently there is no research to compare the value of one stem cell method over another. Induced pluripotent stem … περισσότερα » miR-376c inhibits cervical cancer cell proliferation and invasion by targeting BMI1 medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 34 δευτερόλεπτα Summary MicroRNAs (miRNAs) play crucial roles in cancer development and progression. The purposes of this study were to explore the role of miR-376c in cervical cancer and to clarify the regulation of BMI1 by miR-376c. Quantitative RT-PCR was used to measure miR-376c expression in cervical cancer tissues and cell lines. The cell proliferation, cell cycle […] περισσότερα » miR-376c inhibits cervical cancer cell proliferation and invasion by targeting BMI1 medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 34 δευτερόλεπτα Summary MicroRNAs (miRNAs) play crucial roles in cancer development and progression. The purposes of this study were to explore the role of miR-376c in cervical cancer and to clarify the regulation of BMI1 by miR-376c. Quantitative RT-PCR was used to measure miR-376c expression in cervical cancer tissues and cell lines. The cell proliferation, cell cycle […] περισσότερα » Development of Hemolytic Anemia in a Nivolumab-Treated Patient with Refractory Metastatic Squamous Cell Skin Cancer and Chronic Lymphatic Leukemia medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 34 δευτερόλεπτα Management of patients with metastatic squamous cell skin cancer, refractory to initial therapy with standard chemotherapy and radiation protocols, remains difficult with poor overall prognosis and limited therapeutic options. Recently, promising response rates with nivolumab, a programmed death receptor-1-blocking antibody, in squamous cancer of the head and neck have been demonstrated. Considering the similar histological […] περισσότερα » A Giant Retroperitoneal Liposarcoma Encasing the Entire Left Kidney and Adherent to Adjacent Structures: A Case Report medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 34 δευτερόλεπτα Retroperitoneal liposarcoma is a rare tumor. The dimension and weight of liposarcoma are variable; those over 20 kg are called ‘giant liposarcoma’. Herein, we report giant retroperitoneal liposarcoma measuring 45 cm in diameter and 25 kg in weight encasing the entire left kidney and adherent to adjacent structures. A 71-year-old woman presented for a regular […] περισσότερα » Pazopanib in Primary Cardiac Angiosarcoma of the Right Atrium: A Case Report medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 34 δευτερόλεπτα Primary heart tumors are an extremely rare oncological entity with primary cardiac sarcomas usually representing 20% of all primary cardiac tumorous lesions [Shanmugam: Eur J Cardiothorac Surg 2006;29: 925–932; Orlandi et al.: J Thorac Oncol 2010;5: 1483–1489]. Angiosarcoma is the most prevalent histology and despite a multidisciplinary approach tends to have a dismal prognosis [Shanmugam: […] περισσότερα » Postictal Magnetic Resonance Imaging Changes Masquerading as Brain Tumor Progression: A Case Series medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 34 δευτερόλεπτα Seizures are common among patients with brain tumors. Transient, postictal magnetic resonance imaging abnormalities are a long recognized phenomenon. However, these radiographic changes are not as well studied in the brain tumor population. Moreover, reversible neuroimaging abnormalities following seizure activity may be misinterpreted for tumor progression and could consequently result in unnecessary tumor-directed treatment. Here, […] περισσότερα » Arriving at the Right Diagnosis in an Era of Precision Medicine medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 34 δευτερόλεπτα In the era of precision medicine and targeted therapy, diagnostic inaccuracy can have tremendous ramifications. We present the case of a 61-year-old man initially diagnosed with small cell lung cancer by pathology. Prior to initiating chemotherapy, multidisciplinary discussions led to an amendment of the diagnosis to medullary thyroid cancer. Case Rep Oncol 2016;9:351–357 from #Medicine-SfakianakisAlexandros […] περισσότερα » A Case of Malignant Gastrointestinal Stromal Tumor Initially Misdiagnosed as Malignant B-Cell Lymphoma medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 34 δευτερόλεπτα Errors that occur in anatomic pathology influence the treatment strategy of patients with malignancy. There are four general types of error with three subtypes in the category of defective interpretation. The first subtype is a false-negative diagnosis or undercall of the extent or severity of the lesion, the second is a false-positive diagnosis, and the […] περισσότερα » Sources of protons and a role for bicarbonate in inhibitory feedback from horizontal cells to cones in Ambystoma tigrinum retina Alexandros G. SfakianakisστοPhysiology by Alexandros G.SfakianakisΠριν από 37 δευτερόλεπτα Abstract Lateral-inhibitory feedback from horizontal cells (HCs) to photoreceptors involves changes in synaptic cleft pH accompanying light-evoked changes in HC membrane potential. We analyzed HC to cone feedback by studying surround-evoked light responses of cones and by obtaining paired whole cell recordings from cones and HCs in salamander retina. We tested three potential sources for synaptic cleft protons: 1) generation by extracellular carbonic anhydrase (CA), 2) release from acidic synaptic vesicles, and 3) Na+/H+ exchangers (NHEs). Neither antagonizing extracellular CA nor … περισσότερα » Neuroendocrine Adenoma of the Middle Ear: A Rare Histopathological Diagnosis otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 37 δευτερόλεπτα Neuroendocrine tumours occur throughout the body but are rare in the head and neck region and particularly rare in the middle ear. Clinical findings are often nonspecific and therefore pose a diagnostic challenge. Furthermore, the nomenclature of neuroendocrine tumours of the middle ear is historically controversial. Herein a case is presented of a middle ear […] περισσότερα » Nerve monitoring-guided selective hypoglossal nerve stimulation in obstructive sleep apnea patients otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 37 δευτερόλεπτα Objective/Hypothesis Selective stimulation of the upper airway is a new therapy for obstructive sleep apnea. The aim of the study was to determine if a selective nerve integrity monitoring (NIM) system could aid in precise placement of the cuff electrode in selective upper-airway stimulation. Study Design Single-center, prospective clinical trial. Methods Twenty patients who received […] περισσότερα » Midline posterior glossectomy and lingual tonsillectomy in obese and nonobese children with down syndrome: Biomarkers for success otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 37 δευτερόλεπτα Objectives/Hypothesis To examine outcomes following midline posterior glossectomy (MPG) plus lingual tonsillectomy (LT) for the treatment of significant obstructive sleep apnea (OSA) in children with Down syndrome (DS). Methods Patients with DS who had persistent OSA following tonsillectomy and adenoidectomy (TA) and were relatively intolerant of positive airway pressure (PAP) therapy were evaluated by physical […] περισσότερα » Cochlear implantation for single-sided deafness: A multicenter study otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 37 δευτερόλεπτα Objectives/Hypothesis To report the preliminary outcomes of patients with single-sided deafness and asymmetric hearing loss undergoing cochlear implantation at two centers. Study Design Retrospective review and prospective data collection. Methods Patients with single-sided deafness who underwent cochlear implantation at two centers were included. Pre- and postoperative measures included monosyllabic word and sentence recognition in quiet […] περισσότερα » Managing blocked foley catheter balloons when removing posterior nasal packs in epistaxis patients otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 37 δευτερόλεπτα Level of Evidence NA Laryngoscope, 2016 from #ORL via xlomafota13 on Inoreader http://ift.tt/294r4KW via IFTTT http://ift.tt/28X7r5v περισσότερα » Transoral robotic base of tongue reduction for obstructive sleep apnea: A systematic review and meta-analysis otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 37 δευτερόλεπτα Objectives/Hypothesis To determine the effect of transoral robotic surgery (TORS) base of tongue (BOT) reduction on sleep-related outcomes in patients with obstructive sleep apnea (OSA). Data Sources PubMed, Scopus, EMBASE, CINAHL, Cochrane, and Ovid. Review Methods Literature search by two independent authors was conducted using the abovementioned databases. Studies on TORS BOT reduction as part […] περισσότερα » Extended and treatment-oriented classification of parotid duct stenosis otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 37 δευτερόλεπτα Objectives/Hypothesis To provide an extended and treatment-oriented classification of parotid duct stenosis that might be useful in the management of this condition. Study Design Retrospective study in a tertiary referral center. Methods A total of 550 symptomatic stenoses of the parotid gland excretory duct in 445 patients were analyzed. Sialendoscopy was performed with semirigid endoscopes. […] περισσότερα » Review of videolaryngoscopy pharyngeal wall injuries otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 37 δευτερόλεπτα Objectives Reports of patient injuries associated with videolaryngoscopy are increasing in the literature. There are a wide variety of opinions regarding both safe use of the device and patient care following aerodigestive tract injury. We have seen an increase in videolaryngoscopy-associated injuries in recent years at our institution. Because of this, we wanted to determine […] περισσότερα » Cochlear implantation via round window or cochleostomy: Effect on hearing in an animal model otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 37 δευτερόλεπτα Objectives/Hypothesis Cochlear implantation in patients with residual hearing has increased interest in hearing preservation. Two major surgical approaches to implantation have been devised: via the round window membrane and through cochleostomy. However, the advantages of either approach on hearing preservation have not been established. Due to the great inter- and intravariability among implantees, the current […] περισσότερα » Long-term antibiofilm activity of carboxymethyl chitosan on mixed biofilm on silicone otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 37 δευτερόλεπτα Objectives/Hypothesis Silicone voice prostheses are most frequently used in voice rehabilitation of laryngectomized patients. However, the functional device lifetimes are limited due to formation of mixed biofilms. Existing in vitro models simulating biofilm formation are restricted to only short-term periods. Study Design The goal of this study was to determine the effect of carboxymethyl chitosan […] περισσότερα » Development of Hemolytic Anemia in a Nivolumab-Treated Patient with Refractory Metastatic Squamous Cell Skin Cancer and Chronic Lymphatic Leukemia Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 39 δευτερόλεπτα Management of patients with metastatic squamous cell skin cancer, refractory to initial therapy with standard chemotherapy and radiation protocols, remains difficult with poor overall prognosis and limited therapeutic options. Recently, promising response rates with nivolumab, a programmed death receptor-1-blocking antibody, in squamous cancer of the head and neck have been demonstrated. Considering the similar histological patterns of squamous cell cancer of the skin and squamous cell cancer of the head and neck, we assumed that nivolumab could also be effective in our patients w… περισσότερα » A Giant Retroperitoneal Liposarcoma Encasing the Entire Left Kidney and Adherent to Adjacent Structures: A Case Report Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 39 δευτερόλεπτα Retroperitoneal liposarcoma is a rare tumor. The dimension and weight of liposarcoma are variable; those over 20 kg are called 'giant liposarcoma’. Herein, we report giant retroperitoneal liposarcoma measuring 45 cm in diameter and 25 kg in weight encasing the entire left kidney and adherent to adjacent structures. A 71-year-old woman presented for a regular checkup. Image study revealed a huge mass probably indicative of retroperitoneal liposarcoma encasing the entire left kidney and adherent to adjacent structures. We performed an organ-preserving surgical removal. The pathologi… περισσότερα » Postictal Magnetic Resonance Imaging Changes Masquerading as Brain Tumor Progression: A Case Series Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 39 δευτερόλεπτα Seizures are common among patients with brain tumors. Transient, postictal magnetic resonance imaging abnormalities are a long recognized phenomenon. However, these radiographic changes are not as well studied in the brain tumor population. Moreover, reversible neuroimaging abnormalities following seizure activity may be misinterpreted for tumor progression and could consequently result in unnecessary tumor-directed treatment. Here, we describe two cases of patients with brain tumors who developed peri-ictal pseudoprogression and review the relevant literature. Case Rep Oncol 2016;… περισσότερα » Pazopanib in Primary Cardiac Angiosarcoma of the Right Atrium: A Case Report Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 39 δευτερόλεπτα Primary heart tumors are an extremely rare oncological entity with primary cardiac sarcomas usually representing 20% of all primary cardiac tumorous lesions [Shanmugam: Eur J Cardiothorac Surg 2006;29: 925–932; Orlandi et al.: J Thorac Oncol 2010;5: 1483–1489]. Angiosarcoma is the most prevalent histology and despite a multidisciplinary approach tends to have a dismal prognosis [Shanmugam: Eur J Cardiothorac Surg 2006;29: 925–932; Fury et al.: Cancer J 2005;11: 241–247]. Based on the prevailing literature, we report a 48-year-old woman diagnosed with primary metastatic cardiac ang… περισσότερα » Arriving at the Right Diagnosis in an Era of Precision Medicine Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 39 δευτερόλεπτα In the era of precision medicine and targeted therapy, diagnostic inaccuracy can have tremendous ramifications. We present the case of a 61-year-old man initially diagnosed with small cell lung cancer by pathology. Prior to initiating chemotherapy, multidisciplinary discussions led to an amendment of the diagnosis to medullary thyroid cancer. Case Rep Oncol 2016;9:351–357 from Cancer via xlomafota13 on Inoreader http://ift.tt/28Y9FC7 via IFTTT http://ift.tt/28WTMKw περισσότερα » A Case of Malignant Gastrointestinal Stromal Tumor Initially Misdiagnosed as Malignant B-Cell Lymphoma Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 39 δευτερόλεπτα Errors that occur in anatomic pathology influence the treatment strategy of patients with malignancy. There are four general types of error with three subtypes in the category of defective interpretation. The first subtype is a false-negative diagnosis or undercall of the extent or severity of the lesion, the second is a false-positive diagnosis, and the third is misclassification. We herein report a 65-year-old female patient with malignant gastrointestinal stromal tumor that was diagnosed after reevaluation of the lesion at our hospital – and treated with proximal gastrectomy – … περισσότερα » Skin cancer: An effective but painful treatment Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 39 δευτερόλεπτα Skin cancer: An effective but painful treatment: FAU researchers discover why photodynamic therapy for skin cancer can cause pain. from Melanoma via ola Kala on Inoreader via IFTTT http://ift.tt/28XbXRu περισσότερα » Pharmacological preconditioning for short-term ex vivo expansion of human umbilical cord blood hematopoietic stem cells by filgrastim. Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 39 δευτερόλεπτα Related Articles *Pharmacological preconditioning for short-term ex vivo expansion of human umbilical cord blood hematopoietic stem cells by filgrastim.* Am J Stem Cells. 2016;5(1):29-38 Authors: Grigoriadis NG, Grigoriadis IG, Markoula S, Paschopoulos M, Zikopoulos K, Apostolakopoulos PG, Vizirianakis IS, Georgiou I Abstract Although umbilical cord blood (UCB) hematopoietic stem cell transplantation (UCBT) has emerged as a promising haematological reconstitution therapy for leukemias and other related disorders, the insufficient UCB stem cell dosage still hinders better clinical… περισσότερα » Induction of sensory neurons from neuroepithelial stem cells by the ISX9 small molecule. Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 39 δευτερόλεπτα Related Articles *Induction of sensory neurons from neuroepithelial stem cells by the ISX9 small molecule.* Am J Stem Cells. 2016;5(1):19-28 Authors: Ali RQ, Blomberg E, Falk A, Ährlund-Richter L, Ulfendahl M Abstract Hearing impairment most often involves loss of sensory hair cells and auditory neurons. As this loss is permanent in humans, a cell therapy approach has been suggested to replace damaged cells. It is thus of interest to generate lineage restricted progenitor cells appropriate for cell based therapies. Human long-term self-renewing neuroepithelial stem (lt-NES) cell… περισσότερα » Influence of paternal preconception exposures on their offspring: through epigenetics to phenotype. Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 39 δευτερόλεπτα Related Articles *Influence of paternal preconception exposures on their offspring: through epigenetics to phenotype.* Am J Stem Cells. 2016;5(1):11-8 Authors: Day J, Savani S, Krempley BD, Nguyen M, Kitlinska JB Abstract Historically, research into congenital defects has focused on maternal impacts on the fetal genome during gestation and prenatal periods. However, recent findings have sparked interest in epigenetic alterations of paternal genomes and its effects on offspring. This emergent field focuses on how environmental influences can epigenetically alter gene expression an… περισσότερα » Comparison of stem cell therapies for acute kidney injury. Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 39 δευτερόλεπτα Related Articles *Comparison of stem cell therapies for acute kidney injury.* Am J Stem Cells. 2016;5(1):1-10 Authors: Barnes CJ, Distaso CT, Spitz KM, Verdun VA, Haramati A Abstract Acute kidney injury (AKI) is the rapid onset of decreased kidney function that ultimately increases mortality and morbidity. Stem cell research is a promising avenue for curative and preventative therapies of kidney injury, however, there are many types of stem cells under investigation. Currently there is no research to compare the value of one stem cell method over another. Induced pluripotent stem… περισσότερα » Pharmacological preconditioning for short-term ex vivo expansion of human umbilical cord blood hematopoietic stem cells by filgrastim. Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 39 δευτερόλεπτα Related Articles *Pharmacological preconditioning for short-term ex vivo expansion of human umbilical cord blood hematopoietic stem cells by filgrastim.* Am J Stem Cells. 2016;5(1):29-38 Authors: Grigoriadis NG, Grigoriadis IG, Markoula S, Paschopoulos M, Zikopoulos K, Apostolakopoulos PG, Vizirianakis IS, Georgiou I Abstract Although umbilical cord blood (UCB) hematopoietic stem cell transplantation (UCBT) has emerged as a promising haematological reconstitution therapy for leukemias and other related disorders, the insufficient UCB stem cell dosage still hinders better clinical… περισσότερα » Induction of sensory neurons from neuroepithelial stem cells by the ISX9 small molecule. Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 39 δευτερόλεπτα Related Articles *Induction of sensory neurons from neuroepithelial stem cells by the ISX9 small molecule.* Am J Stem Cells. 2016;5(1):19-28 Authors: Ali RQ, Blomberg E, Falk A, Ährlund-Richter L, Ulfendahl M Abstract Hearing impairment most often involves loss of sensory hair cells and auditory neurons. As this loss is permanent in humans, a cell therapy approach has been suggested to replace damaged cells. It is thus of interest to generate lineage restricted progenitor cells appropriate for cell based therapies. Human long-term self-renewing neuroepithelial stem (lt-NES) cell… περισσότερα » Influence of paternal preconception exposures on their offspring: through epigenetics to phenotype. Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 39 δευτερόλεπτα Related Articles *Influence of paternal preconception exposures on their offspring: through epigenetics to phenotype.* Am J Stem Cells. 2016;5(1):11-8 Authors: Day J, Savani S, Krempley BD, Nguyen M, Kitlinska JB Abstract Historically, research into congenital defects has focused on maternal impacts on the fetal genome during gestation and prenatal periods. However, recent findings have sparked interest in epigenetic alterations of paternal genomes and its effects on offspring. This emergent field focuses on how environmental influences can epigenetically alter gene expression an… περισσότερα » Comparison of stem cell therapies for acute kidney injury. Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 39 δευτερόλεπτα Related Articles *Comparison of stem cell therapies for acute kidney injury.* Am J Stem Cells. 2016;5(1):1-10 Authors: Barnes CJ, Distaso CT, Spitz KM, Verdun VA, Haramati A Abstract Acute kidney injury (AKI) is the rapid onset of decreased kidney function that ultimately increases mortality and morbidity. Stem cell research is a promising avenue for curative and preventative therapies of kidney injury, however, there are many types of stem cells under investigation. Currently there is no research to compare the value of one stem cell method over another. Induced pluripotent stem… περισσότερα » Intrinsic resistance to EGFR tyrosine kinase inhibitors in advanced non-small-cell lung cancer with activating EGFR mutations Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 39 δευτερόλεπτα [image: 88x31.png] from Cancer via xlomafota13 on Inoreader http://ift.tt/291wiIO via IFTTT http://ift.tt/28XSf9p περισσότερα » Association of polymorphisms in interleukin-8 gene with cancer risk: a meta-analysis of 22 case–control studies Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 39 δευτερόλεπτα [image: 88x31.png] from Cancer via xlomafota13 on Inoreader http://ift.tt/28XWAc0 via IFTTT http://ift.tt/29f8mhv περισσότερα » The evolution of combined molecular targeted therapies to advance the therapeutic efficacy in melanoma: a highlight of vemurafenib and cobimetinib Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 39 δευτερόλεπτα [image: 88x31.png] from Cancer via xlomafota13 on Inoreader http://ift.tt/293H7dA via IFTTT http://ift.tt/28XSiSL περισσότερα » miR-376c inhibits cervical cancer cell proliferation and invasion by targeting BMI1 Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 47 δευτερόλεπτα Summary MicroRNAs (miRNAs) play crucial roles in cancer development and progression. The purposes of this study were to explore the role of miR-376c in cervical cancer and to clarify the regulation of BMI1 by miR-376c. Quantitative RT-PCR was used to measure miR-376c expression in cervical cancer tissues and cell lines. The cell proliferation, cell cycle and Transwell invasion assays were performed. A luciferase reporter assay was conducted to confirm the target gene of miR-376c, and the results were validated in cervical cancer cell lines and tissues. MiR-376c was significantly d… περισσότερα » Neuroendocrine Adenoma of the Middle Ear: A Rare Histopathological Diagnosis Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 52 δευτερόλεπτα Neuroendocrine tumours occur throughout the body but are rare in the head and neck region and particularly rare in the middle ear. Clinical findings are often nonspecific and therefore pose a diagnostic challenge. Furthermore, the nomenclature of neuroendocrine tumours of the middle ear is historically controversial. Herein a case is presented of a middle ear adenoma in a 33-year-old patient who presented with otalgia, hearing loss, and facial nerve palsy. A brief discussion is included regarding the histopathological features of middle ear adenomas and seeks to clarify the correc… περισσότερα » Nerve monitoring-guided selective hypoglossal nerve stimulation in obstructive sleep apnea patients Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 52 δευτερόλεπτα [image: cover.gif?v=1&s=fdf3bf895114aa3ba0986593] Objective/Hypothesis Selective stimulation of the upper airway is a new therapy for obstructive sleep apnea. The aim of the study was to determine if a selective nerve integrity monitoring (NIM) system could aid in precise placement of the cuff electrode in selective upper-airway stimulation. Study Design Single-center, prospective clinical trial. Methods Twenty patients who received a selective upper-airway stimulation system (Inspire Medical Systems, Maple Grove, MN) were implanted by using a NIM system. The tongue motions wer… περισσότερα » Midline posterior glossectomy and lingual tonsillectomy in obese and nonobese children with down syndrome: Biomarkers for success Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 52 δευτερόλεπτα Objectives/Hypothesis To examine outcomes following midline posterior glossectomy (MPG) plus lingual tonsillectomy (LT) for the treatment of significant obstructive sleep apnea (OSA) in children with Down syndrome (DS). Methods Patients with DS who had persistent OSA following tonsillectomy and adenoidectomy (TA) and were relatively intolerant of positive airway pressure (PAP) therapy were evaluated by physical examination and sleep/CINE magnetic resonance imaging to determine the etiology of upper airway obstruction. Patients with relative macroglossia underwent MPG plus LT if … περισσότερα » Cochlear implantation for single-sided deafness: A multicenter study Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 52 δευτερόλεπτα [image: cover.gif?v=1&s=fdf3bf895114aa3ba0986593] Objectives/Hypothesis To report the preliminary outcomes of patients with single-sided deafness and asymmetric hearing loss undergoing cochlear implantation at two centers. Study Design Retrospective review and prospective data collection. Methods Patients with single-sided deafness who underwent cochlear implantation at two centers were included. Pre- and postoperative measures included monosyllabic word and sentence recognition in quiet for the ear implanted, and sentence recognition in noise in the best-aided bilateral conditi… περισσότερα » Managing blocked foley catheter balloons when removing posterior nasal packs in epistaxis patients Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 52 δευτερόλεπτα Level of Evidence NA *Laryngoscope*, 2016 from #ORL via xlomafota13 on Inoreader http://ift.tt/294r4KW via IFTTT περισσότερα » Transoral robotic base of tongue reduction for obstructive sleep apnea: A systematic review and meta-analysis Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 52 δευτερόλεπτα [image: cover.gif?v=1&s=fdf3bf895114aa3ba0986593] Objectives/Hypothesis To determine the effect of transoral robotic surgery (TORS) base of tongue (BOT) reduction on sleep-related outcomes in patients with obstructive sleep apnea (OSA). Data Sources PubMed, Scopus, EMBASE, CINAHL, Cochrane, and Ovid. Review Methods Literature search by two independent authors was conducted using the abovementioned databases. Studies on TORS BOT reduction as part of OSA treatment in adult patients with pre- and postoperative apnea–hypopnea index (AHI) scores were included. Studies on TORS as tre… περισσότερα » Extended and treatment-oriented classification of parotid duct stenosis Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 52 δευτερόλεπτα Objectives/Hypothesis To provide an extended and treatment-oriented classification of parotid duct stenosis that might be useful in the management of this condition. Study Design Retrospective study in a tertiary referral center. Methods A total of 550 symptomatic stenoses of the parotid gland excretory duct in 445 patients were analyzed. Sialendoscopy was performed with semirigid endoscopes. The tissue quality, location, grade of luminal narrowing, and length and number of the stenoses were assessed. Results Inflammation-dominant stenosis (type 1) was found in 8.9% of the pati… περισσότερα » Review of videolaryngoscopy pharyngeal wall injuries Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 52 δευτερόλεπτα [image: cover.gif?v=1&s=fdf3bf895114aa3ba0986593] Objectives Reports of patient injuries associated with videolaryngoscopy are increasing in the literature. There are a wide variety of opinions regarding both safe use of the device and patient care following aerodigestive tract injury. We have seen an increase in videolaryngoscopy-associated injuries in recent years at our institution. Because of this, we wanted to determine if video-assisted laryngoscopy presents a greater risk of injury compared with direct laryngoscopy. Furthermore, we wanted to determine if there were patien… περισσότερα » Cochlear implantation via round window or cochleostomy: Effect on hearing in an animal model Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 52 δευτερόλεπτα [image: cover.gif?v=1&s=fdf3bf895114aa3ba0986593] Objectives/Hypothesis Cochlear implantation in patients with residual hearing has increased interest in hearing preservation. Two major surgical approaches to implantation have been devised: via the round window membrane and through cochleostomy. However, the advantages of either approach on hearing preservation have not been established. Due to the great inter- and intravariability among implantees, the current study used a normal-hearing animal model to compare the effect of the two methods on hearing. Study Design Animal study… περισσότερα » Long-term antibiofilm activity of carboxymethyl chitosan on mixed biofilm on silicone Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 52 δευτερόλεπτα [image: cover.gif?v=1&s=fdf3bf895114aa3ba0986593] Objectives/Hypothesis Silicone voice prostheses are most frequently used in voice rehabilitation of laryngectomized patients. However, the functional device lifetimes are limited due to formation of mixed biofilms. Existing in vitro models simulating biofilm formation are restricted to only short-term periods. Study Design The goal of this study was to determine the effect of carboxymethyl chitosan on mixed biofilm formation of fungi and bacteria on silicone over a long-term period. Methods Mixed species biofilms of *Candida alb… περισσότερα » Mesenchymal stem cells have antifibrotic effects on transforming growth factor-β1-stimulated vocal fold fibroblasts Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 52 δευτερόλεπτα Objectives/Hypothesis Mesenchymal stem cells (MSCs) hold therapeutic promise for vocal fold scar, yet the precise mechanism(s) underlying tissue level changes remain unclear. We hypothesize that MSCs interact with native fibroblasts to favorably affect healing. Furthermore, we hypothesize that these interactions vary based on MSC source. Methods Vocal fold fibroblasts (VFFs), adipose-derived stem cells, and bone marrow-derived stem cells (BMSCs) were extracted from Sprague-Dawley rats; and a coculture model was employed culturing VFFs ± transforming growth factor (TGF-β1) (10 ng… περισσότερα » Active middle ear implant coupled bilaterally to the round window despite bilateral implanted stapes prostheses Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 52 δευτερόλεπτα [image: cover.gif?v=1&s=fdf3bf895114aa3ba0986593] After stapes surgery, patients with mixed or moderate hearing loss have limited possibilities for hearing improvement. We are reporting on a patient who underwent stapedotomy bilaterally 20 years ago and had sensorineural and mixed hearing loss. Recurrent otitis externa prevented the use of hearing aids. This patient was treated bilaterally with the Vibrant Soundbridge (Med-El, Innsbruck, Austria) successively. The Schuknecht piston stapes prostheses remained in situ. The Floating Mass Transducer (FMT; Med-El) was coupled to the ro… περισσότερα » Classification of TP53 mutations and HPV predict survival in advanced larynx cancer Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 52 δευτερόλεπτα [image: cover.gif?v=1&s=fdf3bf895114aa3ba0986593] Objectives/Hypothesis Assess tumor suppressor p53 (*TP53*) functional mutations in the context of other biomarkers in advanced larynx cancer. Study Design Prospective analysis of pretreatment tumor *TP53*, human papillomavirus (HPV), Bcl-xL, and cyclin D1 status in stage III and IV larynx cancer patients in a clinical trial. Methods *TP53* exons 4 through 9 from 58 tumors were sequenced. Mutations were grouped using three classifications based on their expected function. Each functional group was analyzed for response to inducti… περισσότερα » Singing voice outcomes following singing voice therapy Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 52 δευτερόλεπτα [image: cover.gif?v=1&s=fdf3bf895114aa3ba0986593] Objectives/Hypothesis The objectives of this study were to describe singing voice therapy (SVT), describe referred patient characteristics, and document the outcomes of SVT. Study Design Retrospective. Methods Records of patients receiving SVT between June 2008 and June 2013 were reviewed (n = 51). All diagnoses were included. Demographic information, number of SVT sessions, and symptom severity were retrieved from the medical record. Symptom severity was measured via the 10-item Singing Voice Handicap Index (SVHI-10). Treatment… περισσότερα » Smoking cessation is associated with improved survival in oropharynx cancer treated by chemoradiation Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 52 δευτερόλεπτα Objectives/Hypothesis The effect of smoking and human papillomavirus (HPV) on overall survival (OS) of oropharyngeal squamous cell carcinoma (OPSCC) patients undergoing concurrent chemotherapy (CCRT) remains unclear. Study Design Retrospective review. Methods Clinical characteristics of OPSCC patients treated between 2008 and 2015 with CCRT were abstracted from medical records. OS curves and multivariate cox proportional hazard ratios (HRs) were examined. Results Of 120 evaluable patients, 71% had HPV+ tumors. Median follow-up duration for the entire cohort was 41.5 months (ra… περισσότερα » In reference to Spontaneous middle cranial fossa cerebrospinal fluid otorrhea in adults Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 52 δευτερόλεπτα [image: cover.gif?v=1&s=fdf3bf895114aa3ba0986593] from #ORL via xlomafota13 on Inoreader http://ift.tt/28VmWsF via IFTTT περισσότερα » The evolution of combined molecular targeted therapies to advance the therapeutic efficacy in melanoma: a highlight of vemurafenib and cobimetinib Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 53 δευτερόλεπτα [image: 88x31.png] from Melanoma via xlomafota13 on Inoreader http://ift.tt/293H7dA περισσότερα » Pharmacological preconditioning for short-term ex vivo expansion of human umbilical cord blood hematopoietic stem cells by filgrastim. Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα Related Articles *Pharmacological preconditioning for short-term ex vivo expansion of human umbilical cord blood hematopoietic stem cells by filgrastim.* Am J Stem Cells. 2016;5(1):29-38 Authors: Grigoriadis NG, Grigoriadis IG, Markoula S, Paschopoulos M, Zikopoulos K, Apostolakopoulos PG, Vizirianakis IS, Georgiou I Abstract Although umbilical cord blood (UCB) hematopoietic stem cell transplantation (UCBT) has emerged as a promising haematological reconstitution therapy for leukemias and other related disorders, the insufficient UCB stem cell dosage still hinders better clinical … περισσότερα » Induction of sensory neurons from neuroepithelial stem cells by the ISX9 small molecule. Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα Related Articles *Induction of sensory neurons from neuroepithelial stem cells by the ISX9 small molecule.* Am J Stem Cells. 2016;5(1):19-28 Authors: Ali RQ, Blomberg E, Falk A, Ährlund-Richter L, Ulfendahl M Abstract Hearing impairment most often involves loss of sensory hair cells and auditory neurons. As this loss is permanent in humans, a cell therapy approach has been suggested to replace damaged cells. It is thus of interest to generate lineage restricted progenitor cells appropriate for cell based therapies. Human long-term self-renewing neuroepithelial stem (lt-NES) cell … περισσότερα » Influence of paternal preconception exposures on their offspring: through epigenetics to phenotype. Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα Related Articles *Influence of paternal preconception exposures on their offspring: through epigenetics to phenotype.* Am J Stem Cells. 2016;5(1):11-8 Authors: Day J, Savani S, Krempley BD, Nguyen M, Kitlinska JB Abstract Historically, research into congenital defects has focused on maternal impacts on the fetal genome during gestation and prenatal periods. However, recent findings have sparked interest in epigenetic alterations of paternal genomes and its effects on offspring. This emergent field focuses on how environmental influences can epigenetically alter gene expression and… περισσότερα » Comparison of stem cell therapies for acute kidney injury. Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα Related Articles *Comparison of stem cell therapies for acute kidney injury.* Am J Stem Cells. 2016;5(1):1-10 Authors: Barnes CJ, Distaso CT, Spitz KM, Verdun VA, Haramati A Abstract Acute kidney injury (AKI) is the rapid onset of decreased kidney function that ultimately increases mortality and morbidity. Stem cell research is a promising avenue for curative and preventative therapies of kidney injury, however, there are many types of stem cells under investigation. Currently there is no research to compare the value of one stem cell method over another. Induced pluripotent stem … περισσότερα » Pharmacological preconditioning for short-term ex vivo expansion of human umbilical cord blood hematopoietic stem cells by filgrastim. Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα Related Articles *Pharmacological preconditioning for short-term ex vivo expansion of human umbilical cord blood hematopoietic stem cells by filgrastim.* Am J Stem Cells. 2016;5(1):29-38 Authors: Grigoriadis NG, Grigoriadis IG, Markoula S, Paschopoulos M, Zikopoulos K, Apostolakopoulos PG, Vizirianakis IS, Georgiou I Abstract Although umbilical cord blood (UCB) hematopoietic stem cell transplantation (UCBT) has emerged as a promising haematological reconstitution therapy for leukemias and other related disorders, the insufficient UCB stem cell dosage still hinders better clinical … περισσότερα » Influence of paternal preconception exposures on their offspring: through epigenetics to phenotype. Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα Related Articles *Influence of paternal preconception exposures on their offspring: through epigenetics to phenotype.* Am J Stem Cells. 2016;5(1):11-8 Authors: Day J, Savani S, Krempley BD, Nguyen M, Kitlinska JB Abstract Historically, research into congenital defects has focused on maternal impacts on the fetal genome during gestation and prenatal periods. However, recent findings have sparked interest in epigenetic alterations of paternal genomes and its effects on offspring. This emergent field focuses on how environmental influences can epigenetically alter gene expression and… περισσότερα » Induction of sensory neurons from neuroepithelial stem cells by the ISX9 small molecule. Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα Related Articles *Induction of sensory neurons from neuroepithelial stem cells by the ISX9 small molecule.* Am J Stem Cells. 2016;5(1):19-28 Authors: Ali RQ, Blomberg E, Falk A, Ährlund-Richter L, Ulfendahl M Abstract Hearing impairment most often involves loss of sensory hair cells and auditory neurons. As this loss is permanent in humans, a cell therapy approach has been suggested to replace damaged cells. It is thus of interest to generate lineage restricted progenitor cells appropriate for cell based therapies. Human long-term self-renewing neuroepithelial stem (lt-NES) cell … περισσότερα » Comparison of stem cell therapies for acute kidney injury. Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα Related Articles *Comparison of stem cell therapies for acute kidney injury.* Am J Stem Cells. 2016;5(1):1-10 Authors: Barnes CJ, Distaso CT, Spitz KM, Verdun VA, Haramati A Abstract Acute kidney injury (AKI) is the rapid onset of decreased kidney function that ultimately increases mortality and morbidity. Stem cell research is a promising avenue for curative and preventative therapies of kidney injury, however, there are many types of stem cells under investigation. Currently there is no research to compare the value of one stem cell method over another. Induced pluripotent stem … περισσότερα » Fibrous Dysplasia of the Temporal Bone Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα with External Auditory Canal Stenosis and Secondary Cholesteatoma Yu-Hsi Liu 1 , Kuo-Ping Chang 1 1 Department of Otorhinolaryngology – Head and Neck Surgery, Kaohsiung Veterans General Hospital, Kaohsiung City, Thaiwan, Province of China J Int Adv Otol 2016; 12: 125-128 DOI: 10.5152/iao.2016.1381 Abstract Fibrous dysplasia is a slowly progressive benign fibro-osseous disease, rarely occurring in temporal bones. In these cases, most bony lesions developed from the bony part of the external auditory canals, causing otalgia, hearing impairment, otorrhea, and ear hygiene blockade … περισσότερα » Syringocystadenomapapilliferum Arising from the External Auditory Canal Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα : A Rare Tumor in a Rare Site Hazem M. Abdel Tawab 1 , Khalid F. Amish 2 , Ibrahim A. Sulaiman 3 , Rubyath C. Rajib 3 1 Department of Otorhinolaryngology, Cairo University School of Medicine, Cairo, Egypt; Department of Otorhinolaryngology, Sultan Qaboos Hospital, Salalah, Oman 2 Department of Otorhinolaryngology, Sultan Qaboos Hospital, Salalah, Oman. 3 Department of Pathology, Sultan Qaboos Hospital, Salalah, Oman J Int Adv Otol 2016; 12: 116-118 DOI: 10.5152/iao.2016.2036 Abstract Syringocystadenomapapilliferum is an extremely rare benign adnexal tumor of the scalp an… περισσότερα » Anterior Displacement of the Geniculate Ganglion Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα Tomoyasu Tachibana 1 , Yorihisa Orita 2 , Kazunori Nishizaki 2 1 Clinic of Otolaryngology, Himeji Red Cross Hospital, Himeji, Japan 2 Department of Otolaryngology, Okayama University School of Medicine, Okayama, Japan J Int Adv Otol 2016; 12: 113-115 DOI: 10.5152/iao.2016.1559 Abstract We present the case of a 34-year-old Japanese woman with cholesteatoma of the middle ear. During the operation, this patient showed an unusual position of the geniculate ganglion. We reviewed the computed tomography (CT) images targeting the ear of the present case after the operation. We fo… περισσότερα » Cochlear Implantation Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα Alternative Techniques in Özgür Sürmelioğlu 1 , Süleyman Özdemir 1 , Özgür Tarkan 1 , Ülkü Tuncer 1 , Fikret Çetik 1 , Karahan Kara 1 , Mete Kıroğlu 1 J Int Adv Otol 2016; 12: 109-112 DOI: 10.5152/iao.2015.1022 Abstract *OBJECTIVE*: To review the alternative techniques in cochlear implantation and to compare the complications with different techniques. *MATERIALS and METHODS*: Patients who had undergone cochlear implantation were reviewed. Those patients who were operated using alternative techniques were selected and evaluated for the cause of their hearing loss and f… περισσότερα » Eustachian Tube Dysfunction Questionnaire Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα Responsiveness of the 7-item Shari Van Roeyen 1 , Paul Van de Heyning 1 , Vincent Van Rompaey 1 1 Antwerp University Hospital, Otorhinolaryngology and Head and Neck Surgery, Edegem, Belgium; University of Antwerp, School of Medicine and Health Sciences, Wilrijk, Belgium J Int Adv Otol 2016; 12: 106-108 DOI: 10.5152/iao.2016.2086 Abstract *OBJECTIVE*: Baro-challenge-induced Eustachian tube (ET) dysfunction is defined as the presence of aural discomfort, popping, or pain, which only arises in case of ambient pressure changes, without abnormalities on otoscopy or tympanometry. … περισσότερα » Oxidative Stress and Inflammatory Mediators in Benign Paroxysmal Positional Vertigo Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα The Role of Mehmet Taylan Güçlütürk 1 , Zeynep Nil Ünal 2 , Onur İsmi 1 , Mehmet Burak Yavuz Çimen 3 , Murat Ünal 1 1 Department of Otorhinolaryngology, Mersin University School of Medicine, Mersin, Turkey 2 Department of Biochemistry, Mersin University School of Medicine, Mersin, Turkey 3 Department of Medical Biochemistry, Mersin University School of Medicine, Mersin, Turkey J Int Adv Otol 2016; 12: 101-105 DOI: 10.5152/iao.2015.1412 Abstract *OBJECTIVE*: Benign paroxysmal positional vertigo (BPPV) is the most common peripheral cause of vertigo. It can be defined as… περισσότερα » Asymmetrical Audiovestibular Symptoms Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα The Agreement between Protocols for the Investigation of Robert Nash 1 , Anooj Majithia 1 , Arvind Singh 1 1 Department of Otolaryngology, Head and Neck Surgery, Northwick Park Hospital, London, United Kingdom J Int Adv Otol 2016; 12: 98-100 DOI: 10.5152/iao.2016.1581 Abstract *OBJECTIVE*: There are a number of published criteria for the investigation of asymmetrical audiovestibular symptoms. Our aim was to determine the agreement between these protocols when determining whether to investigate a group of patients treated at our institution. *MATERIALS and METHODS*: Retrospec… περισσότερα » Vertigo Spells Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα Response Over Time of Vertigo Spells to Intratympanic Dexamethasone Treatment in Meniere’s Disease Patients Nabil Atrache Al Attrache 1 , Claudio Krstulovic 1 , Vanesa Pérez Guillen 1 , Constantino Morera Pérez 1 , Herminio Pérez Garrigues 1 J Int Adv Otol 2016; 12: 92-97 DOI: 10.5152/iao.2016.2177 Abstract *OBJECTIVE*: To assess the effectiveness and response over time of intratympanic dexamethasone on the symptoms of Meniere’s disease. *MATERIALS and METHODS*: We performed a matched cohort study of 24 patients with Meniere’s disease who were unresponsive to initial treatme… περισσότερα » Increased Velocity Storage in Subjects with Meniere’s Disease Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα Claudio Krstulovic 1 , Nabil Atrache Al Attrache 1 , Herminio Pérez Garrigues 2 , Herminia Argente-Escrig 3 , Luis Bataller Alberola 3 , Constantino Morera Pérez 2 1 Department of Otolaryngology, Hospital Universitario y Politécnico La Fe, Valencia, Spain. 2 Department of Otolaryngology, Hospital Universitario La Fe, Valencia, Spain. 3 Department of Neurology, Hospital Universitario y Politécnico La Fe, Valencia, Spain J Int Adv Otol 2016; 12: 87-91 DOI: 10.5152/iao.2016.1947 Abstract *OBJECTIVE*: Velocity storage mechanism is a multisensory rotation estimator; it c… περισσότερα » Wideband Tympanometry Normative Data for Different Age Groups Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα in Turkish Population Abdulkadir Özgür 1 , Banu Müjdeci 2 , Suat Terzi 1 , Zerrin Özergin Coşkun 1 , Enes Yiğit 1 , Engin Dursun 1 1 Department of Otorhinolaryngology, Recep Tayyip Erdoğan University School of Medicine, Rize, Turkey 2 Department of Audiology, Yıldırım Beyazıt University Institute of Health Sciences, Ankara, Turkey J Int Adv Otol 2016; 12: 82-86 DOI: 10.5152/iao.2015.1408 Abstract *OBJECTIVE*: Studies on the use of wideband tympanometry (WBT) for the evaluation of middle ear pathologies have been increasing gradually in recent years. However, studies r… περισσότερα » Severe Chronic Tinnitus : Angiotensin-Converting Enzyme (ACE) I/D and Alpha-Adducin (ADD1) G460W Gene Polymorphisms Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα in Turkish Patients with Severe Chronic Tinnitus Salim Yüce 1 , Enver Sancakdar 2 , Gökhan Bağcı 3 , Sema Koç 4 , Hande Küçük Kurtulgan 3 , Binnur Bağcı 5 , Mansur Doğan 1 , İsmail Önder Uysal 1 1 Department of Otorhinolaryngology, Cumhuriyet University School of Medicine, Sivas, Turkey. 2 Department of Biochemistry, Cumhuriyet University School of Medicine, Sivas, Turkey 3 Department of Medical Genetics, Cumhuriyet University School of Medicine, Sivas, Turkey 4 Department of Ear Nose Throat Head and Neck Surgery, Antalya Training and Research Hospital, Antalya, … περισσότερα » Tinnitus Retraining Therapy Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα in Unilateral Tinnitus Patients with Single Side Deafness Sang Hoon Kim 1 , Jae Yong Byun 1 , Seung Geun Yeo 1 , Moon Suh Park 1 1 Department of Otorhinolaryngology, Kyung Hee University Graduate School, Seoul, Korea J Int Adv Otol 2016; 12: 72-76 DOI: 10.5152/iao.2016.1949 Abstract *OBJECTIVE*: The purpose of this study was to evaluate the audiologic and clinical characteristics of the tinnitus in single-sided deafness (SSD) patients and to determine whether tinnitus retraining therapy (TRT) is beneficial to those patients who suffer from tinnitus with SSD. *MATERIALS and… περισσότερα » Intensity on the Speech Evoked Auditory Late Latency Response Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα The Effect of Intensity on the Speech Evoked Auditory Late Latency Response in Normal Hearing Individuals Hari Prakash 1 , Aju Abraham 1 , Bellur Rajashekar 1 , Krishna Yerraguntla 1 1 Department of Speech and Hearing, School of Allied Health Science, Karnataka, India J Int Adv Otol 2016; 12: 67-71 DOI: 10.5152/iao.2016.1776 Abstract *OBJECTIVE*: Among the stimulus factors, the influence of presentation level is less studied in normal-hearing individuals when using speech stimuli withvarious presentation levels for the auditory late latency response (ALLR). Hence, the prese… περισσότερα » Smartphone Based Audiometric Test Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα for Confirming the Level of Hearing; Is It Useable in Underserved Areas? Levent Renda 1 , Ömer Tarık Selçuk 1 , Hülya Eyigör 1 , Üstün Osma 1 , Mustafa Deniz Yılmaz 1 1 Department of Ear Nose and Throat, Antalya Training and Research Hospital, Antalya, Turkey J Int Adv Otol 2016; 12: 61-66 DOI: 10.5152/iao.2016.1421 Abstract *OBJECTIVE*: To determine the hearing levels of participants of a randomized group using a smartphone hearing application and to compare these results with the results from a pure-tone audiogram. *MATERIALS and METHODS*: A heterogenous group consistin… περισσότερα » Hearing Screening Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα Follow-Up Results of Newborns after Hearing Screening at a Training and Research Hospital in Turkey Rasim Yılmazer 1 , Mine Zahide Yazıcı 2 , İbrahim Erdim 2 , Hakan Kamil Kaya 2 , Şengül Özcan Dalbudak 2 , Tülin Fatma Kayhan 2 1 Department of Otolaryngology-Head and Neck Surgery, University of Miami Miller School of Medicine, Miami, FL, USA; Department of Otolaryngology-Head and Neck Surgery, İstanbul Medipol University, İstanbul, Turkey 2 Department of Otorhinolaryngology, Bakırköy Dr. Sadi Konuk Training and Research Hospital, İstanbul, Turkey J Int Adv Otol 2016; 1… περισσότερα » Hearing Loss in Persons Exposed and not Exposed to Occupational Noise Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα Martina Kovalova 1 , Eva Mrazkova 1 , Petra Sachova 2 , Kristyna Vojkovska 3 , Hana Tomaskova 1 , Jana Janoutova 1 , Vladimir Janout 1 1 Department of Epidemiology and Public Health, University of Ostrava Faculty of Medicine, Ostrava, Czech Republic 2 Department of Preventive Medicine, Palacký University Olomouc, Faculty of Medicine and Dentistry, Olomouc, Czech Republic 3 Center for Hearing and Balance Disorders, Ostrava, Czech Republic J Int Adv Otol 2016; 12: 49-54 DOI: 10.5152/iao.2016.1770 Abstract *OBJECTIVE*: This study aimed to compare hearing loss in indivi… περισσότερα » Radiological Imaging Findings of Patients with Congenital Totally Hearing Loss Αλέξανδρος ΣφακιανάκηςστοChemical Senses by Alexandros G. SfakianakisΠριν από 1 ώρα Muhammed Dağkıran 1 , Nermin Dağkıran 2 , Özgür Sürmelioğlu 1 , Tuğsan Ballı 2 , Ülkü Tuncer 1 , Erol Akgül 2 , Fikret Çetik 1 1 Department of Otorhinolaryngology, Çukurova University School of Medicine, Adana, Turkey 2 Department of Radiology, Çukurova University School of Medicine, Adana, Turkey J Int Adv Otol 2016; 12: 43-48 DOI: 10.5152/iao.2015.1450 Abstract OBJECTIVE: The aim of this study was to determine and classify inner ear abnormalities in patients who had cochlear implants because of congenital sensorineural hearing loss using preoperative temporal bone com… περισσότερα » Development of Hemolytic Anemia in a Nivolumab-Treated Patient with Refractory Metastatic Squamous Cell Skin Cancer and Chronic Lymphatic Leukemia medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα Management of patients with metastatic squamous cell skin cancer, refractory to initial therapy with standard chemotherapy and radiation protocols, remains difficult with poor overall prognosis and limited therapeutic options. Recently, promising response rates with nivolumab, a programmed death receptor-1-blocking antibody, in squamous cancer of the head and neck have been demonstrated. Considering the similar histological […] περισσότερα » A Giant Retroperitoneal Liposarcoma Encasing the Entire Left Kidney and Adherent to Adjacent Structures: A Case Report medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα Retroperitoneal liposarcoma is a rare tumor. The dimension and weight of liposarcoma are variable; those over 20 kg are called ‘giant liposarcoma’. Herein, we report giant retroperitoneal liposarcoma measuring 45 cm in diameter and 25 kg in weight encasing the entire left kidney and adherent to adjacent structures. A 71-year-old woman presented for a regular […] περισσότερα » Pazopanib in Primary Cardiac Angiosarcoma of the Right Atrium: A Case Report medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα Primary heart tumors are an extremely rare oncological entity with primary cardiac sarcomas usually representing 20% of all primary cardiac tumorous lesions [Shanmugam: Eur J Cardiothorac Surg 2006;29: 925–932; Orlandi et al.: J Thorac Oncol 2010;5: 1483–1489]. Angiosarcoma is the most prevalent histology and despite a multidisciplinary approach tends to have a dismal prognosis [Shanmugam: […]from Medicine by Alexandros G. Sfakianakis http://ift.tt/294FdYA
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Dendritic cell targeted vaccination
Yesterday, 27 Ιουνίου 2016, 2:57:41 μμ | Alexandros G. Sfakianakis
How do I steer this thing? Using dendritic cell targeted vaccination to more effectively guide the antitumor immune response with combination immunotherapy:
Abstract
Mounting an immune response sufficient to eradicate a tumor is the goal of modern immunotherapy. Single agent therapies with checkpoint inhibitors or costimulatory molecule agonists are effective only for a small portion of all treated patients. Combined therapy, e.g., CTLA-4 and PD-1 checkpoint blockade, is a more effective treatment modality, but in preclinical studies OX40 agonism with CTLA-4 blockade using monoclonal antibodies (aOX40/aCTLA-4) failed to induce tumor regression of larger, more established tumors. We hypothesized that administration of a vaccine with a tumor-associated antigen targeted to the appropriate antigen presenting cell could make combined aOX40/aCTLA-4 therapy more effective. We administered an antibody-based vaccine targeting HER2 to the DEC-205 endocytic receptor on cross-presenting dendritic cells (anti-DEC-205/HER2; aDEC-205/HER2) and a potent adjuvant (poly (I:C)) to assist with maturation, along with aOX40/aCTLA-4 therapy. This therapy induced complete regression of established tumors and a pronounced infiltration of effector CD8 and CD4 T cells, with no effect on regulatory T cell infiltration compared to aOX40/aCTLA-4 alone. To be maximally effective, this therapy required expression of both OX40 and CTLA-4 on CD8 T cells. These data indicate that vaccination targeting cross-presenting dendritic cells with a tumor-associated antigen is a highly effective immunization strategy that can overcome some of the limitations of current systemic immunotherapeutic approaches that lack defined tumor-directed antigenic targets.Circulating regulatory T cells in advanced melanoma patients treated with neoadjuvant ipilimumab
Yesterday, 27 Ιουνίου 2016, 2:57:41 μμ | Alexandros G. Sfakianakis
Phenotypic and functional testing of
Abstract
Background
We have previously investigated neoadjuvant ipilimumab (ipi) for patients with locally/regionally advanced melanoma. That initial assessment of peripheral blood mononuclear cells (PBMC) showed a significant increase in shared tumor associated antigen specific CD4+ and CD8+ T cell activation. We also observed a transient increase in circulating T regulatory cells (Treg) with a parallel increase in total CD4+ T cells, as well as a significant decrease in circulating myeloid derived suppressor cells (MDSC). The increase in circulating Treg frequency, as assessed at 6 weeks after initiation of ipilimumab, was significantly associated with improved progression free survival (PFS, p = 0.034; HR = 0.57) and returned to baseline levels by 12 weeks. To shed light on the unexpected positive correlation between increased Treg and PFS, we here investigated the suppressive activity of circulating Treg at baseline and 6 weeks.Methods
Patients were treated with ipi (10 mg/kg intravenously every 3 weeks for 2 doses) bracketing definitive surgery. Treg (CD4+CD25+CD127dim/-) were isolated from pre-ipi (baseline) and post-ipi (6 weeks) PBMC samples. Treg were co-cultured with autologous responder CD4+ T cells that were stimulated with OKT3/IL-2/CD28 and CFSE-labeled T cells. 1:1, 1:2, and 1:5 ratios were tested. Flow cytometery was used to evaluate the degree of Treg proliferation suppression.Results
Thirty-five patients were enrolled in the study; 18 patients had adequate PBMC samples with sufficient Treg isolated for Treg functional analysis. At 6 weeks following ipi, a decrease in percent of maximal inhibition of Th by Treg compared to baseline was seen for some patients. Scatter plot analysis showed no association between Treg frequency and function at any ratio or between circulating Treg frequency and function at baseline and at 6 weeks post-ipi. An increase in Treg suppressive function was significantly associated with a decrease in PFS (p = 0.02).Conclusions
We find that Treg frequency measures do not correlate with suppressive activity measured ex vivo. Treg suppressive activity increases correlate with poorer patient outcomes.
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