Preparation of carboxymethyl chitosan nanofibers through electrospinning the ball-milled nanopowders with poly (lactic acid) and the blood compatibility of the electrospun NCMC/PLA mats

Abstract

Carboxymethyl chitosan was pulverized to nanopowder (NCMC) with a diameter of 483 nm through ball-milling. 400 mg NCMC was successfully electrospun to nanofibers with the assistant of 4 g poly (lactic acid) (PLA) to prepare NCMC/PLA nanofibrous composite mats. Scanning electron microscope images revealed that there were no NCMC particles in the NCMC/PLA mats, indicating NCMC had been stretched to nanofibers. NCMC/PLA mats with different morphology could be prepared through adjusting the electrospinning voltage at 12–30 kV and the distance at 10–22 cm. The presence of NCMC increased the spinnability of PLA according to the electrospinning parameters. X-ray photoelectron spectroscopy and Fourier transform infrared spectroscopy verified the existence of NCMC in the mats. Crosslinking with glutaraldehyde increased the stability of NCMC/PLA in water. Crosslinked NCMC/PLA mats expressed good blood compatibility according to the results of blood clotting time and platelet adhesion experiment. The methodology of preparation nanofibers from polymer nanopowders through electrospinning could be used to prepare more composite nanofibers while adopting different raw materials.

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