Hematopoiesis Lineage Tree Uprooted: Every Cell Is a Rainbow

Publication date: 10 April 2017
Source:Developmental Cell, Volume 41, Issue 1
Author(s): Karen K. Hirschi, Stefania Nicoli, Kenneth Walsh
Differentiation of hematopoietic stem cells into distinct cell types was thought to occur through a series of discrete, stable progenitor states. Work from Velten et al. (2017) now shows that hematopoietic cells differentiate via a mechanism of continuous lineage priming and thus represent a CLOUD-HSPC.

Teaser

Differentiation of hematopoietic stem cells into distinct cell types was thought to occur through a series of discrete, stable progenitor states. Work from Velten et al. (2017) now shows that hematopoietic cells differentiate via a mechanism of continuous lineage priming and thus represent a CLOUD-HSPC.


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