In vitro and in vivo immunomodulatory activity of sulfated polysaccharide from Porphyra haitanensis.

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In vitro and in vivo immunomodulatory activity of sulfated polysaccharide from Porphyra haitanensis.

Carbohydr Polym. 2017 Jun 01;165:189-196

Authors: Liu QM, Xu SS, Li L, Pan TM, Shi CL, Liu H, Cao MJ, Su WJ, Liu GM

Abstract
The immunoregulatory activity of sulfated polysaccharide from Porphyra haitanensis (PHPS) was investigated in a RAW264.7 macrophages cell model and a BALB/c murine model. The subpopulation of dendritic cells (DCs) and regulatory T cells (Tregs) from PHPS-treated mice splenocytes were also measured by flow cytometry. Consistent with previous reports, we showed that PHPS increased the phagocytosis of RAW264.7 macrophages, and enhanced the secretion of interleukin (IL)-6, IL-10 and tumor necrosis factor-α (TNF-α). Meanwhile, PHPS induced the production of nitric oxide via the Jun N-terminal kinase (JNK) and the Janus kinase (JAK2) signaling pathways in RAW264.7 macrophages. Furthermore, PHPS promoted the proliferation of mice lymphocytes, inducing the generation of TNF-α and IL-10 in vivo, as well as the subpopulation of CD4+ splenic T lymphocytes, DCs, and Tregs. These results indicated that PHPS plays key roles in immunoregulation and may be apply to develop new health foods.

PMID: 28363539 [PubMed - in process]

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