Publication date: July 2017
Source:Biomaterials, Volume 132
Author(s): Wenya He, Kelong Ai, Chunhuan Jiang, Yuanyuan Li, Xiangfu Song, Lehui Lu
Titanium nitride, an alternative plasmonic material to gold with unique physiochemical properties, has been widely used in microelectronics, biomedical devices and food-contact applications. However, its potential application in the area of biomedicine has not been effectively explored. With the spectral match of their plasmon resonance band and the biological transparency window as well as good biocompatibility, titanium nitride nanoparticles (TiN NPs) are promising photoabsorbing agents for photothermal therapy (PTT) and photoacoustic imaging. Nevertheless, the photothermal performance of TiN NPs has not been investigated until now. Here, we presented the investigation of employing TiN NPs as photoabsorbing agents for in vivo photoacoustic tomography (PAT) imaging-guided photothermal cancer therapy. Our experimental results showed that TiN NPs could strongly absorb the NIR light and provided up to 48% photothermal conversion efficiency. After PEGylation, the resultant nanoparticles demonstrated improved physiological stability and extensive blood retention. Following intravenously administration, they could simultaneously enhance the photoacoustic signals of the tumor region and destroy tumors in the tumor-bearing mouse model by taking advantage of the photothermal effect of the TiN NPs. Our findings highlighted the great potential of plasmonic TiN NPs in detection and treatment of cancer.
http://ift.tt/2o0eTlN
http://ift.tt/2p3FoLU
Ιατρική : Τα αισθητικά συστήματα της όρασης,ακοής,αφής,γεύσης και όσφρησης.
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δημοφιλείς αναρτήσεις
-
Summary Background Hand eczema is more common in healthcare workers compared to the general population. The hands are subject to changin...
-
PARAMEDIC SUPPLIED "TAKE HOME" NALOXONE: A RANDOMISED FEASIBILITY STUDY : Introduction "Take Home" Naloxone (THN) kits...
-
Abstract Dissolution is an important property that influences nanoparticle abundance and biological responses, and often becomes a critica...
-
Effect of Elevated Intracranial Pressure on Amplitudes and Frequency Tuning of Ocular Vestibular Evoked Myogenic Potentials Elicited by Bone...
-
Abstract Background Infants with acute lymphoblastic leukemia (ALL) treated with high-dose methotrexate may have reduced methotrexate cl...
-
The post Why We Avoid Mercury Fillings – We Use Safe Composite Resin Fillings To Match Your Tooth Colour appeared first on Family Dentistry...
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου