Imprinting of a Non-pheromonal Cue and Its Protective Effect on Alien Male-Induced Implantation Failure in Mice.

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Imprinting of a Non-pheromonal Cue and Its Protective Effect on Alien Male-Induced Implantation Failure in Mice.

Chem Senses. 2018 Jul 05;:

Authors: Kurisinkal JT, Prathapan PK, Sreedharan R

Abstract
Bruce effect or alien male-induced implantation failure is a well-studied phenomenon in mice. The presence of stud male during exposure to an alien male protects the female from implantation failure. The pheromones of the stud male are imprinted in the female at the time of mating and act as a luteotrophic agent. We tested whether a non-pheromonal cue exposed to the female during pericopulatory sensitive period could protect pregnancy in newly inseminated females exposed to alien males. Virgin females were allowed to mate in presence of a cotton ball smeared with groundnut oil as a non-pheromonal cue. When these females were exposed to alien males in presence of groundnut oil, the majority of the females retained their pregnancy. We evidenced that a non-pheromonal cue could possibly protect the female from alien male-induced implantation failure. The majority of the females exposed to the non-pheromonal cue during the pre-or post-copulatory interactions with the males, exhibited higher rate of pregnancy failure on re-exposure to the same cue at the time of exposure to alien males. The protective effect of the non-pheromonal cue is observed only when the female is exposed to it during the pericopulatory sensitive period.

PMID: 29982306 [PubMed - as supplied by publisher]

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