Epstein–Barr virus: more than 50 years old and still providing surprises

Epstein–Barr virus: more than 50 years old and still providing surprises:

Nature Reviews Cancer 16, 789 (2016).
doi:10.1038/nrc.2016.92

Authors: Lawrence S. Young, Lee Fah Yap & Paul G. Murray

It is more than 50 years since the Epstein–Barr virus (EBV), the first human tumour virus, was discovered. EBV has subsequently been found to be associated with a diverse range of tumours of both lymphoid and epithelial origin. Progress in the molecular analysis of EBV has revealed fundamental mechanisms of more general relevance to the oncogenic process. This Timeline article highlights key milestones in the 50-year history of EBV and discusses how this virus provides a paradigm for exploiting insights at the molecular level in the diagnosis, treatment and prevention of cancer.

Subject terms: B-cell lymphoma Gastric cancer Head and neck cancer Hodgkin lymphoma Risk factors Tumour virus infections

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