The effect of tumour necrosis factor inhibitor therapy on the incidence of myocardial infarction in patients with psoriasis: A retrospective study.

The effect of tumour necrosis factor inhibitor therapy on the incidence of myocardial infarction in patients with psoriasis: A retrospective study.

J Dermatolog Treat. 2016 Nov 24;:1-21

Authors: Shaaban D, Al-Mutairi N

Abstract
BACKGROUND: Psoriasis has been shown to be associated with increased incidence of myocardial infarction (MI). The data on the effect of tumour necrosis factor (TNF) inhibitors on MI in psoriasis are scarce.
OBJECTIVE: To evaluate the effect of TNF inhibitors on the risk of MI in psoriasis patients compared with methotrexate (MTX) and topical agents.
METHODS: Data was obtained from the Electronic Health Records database of Farwaniya Hospital from psoriasis patients seen from January 2008 to December 2014. Patients were categorized into TNF inhibitor, MTX and topical cohorts.
RESULTS: The study included 4762 psoriasis patients. Both TNF inhibitor and MTX cohorts showed a statistically lower rate of MI compared to topical cohort. However, there was no statistically significant difference in MI rate between TNF inhibitor and MTX cohorts (P= 0.32). The probability of MI was lower in TNF inhibitor responders compared to non-responders (P = 0.001).
CONCLUSION: The use of TNF inhibitors in psoriasis showed a significant reduction in the risk of MI compared to topical agents and a non-significant reduction compared to MTX. Responders to TNF inhibitor therapy showed a reduction in MI rate compared with non-responders.

PMID: 27881030 [PubMed - as supplied by publisher]

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