Salivary biomarkers as tools for oral squamous cell carcinoma diagnosis: A systematic review.

Salivary biomarkers as tools for oral squamous cell carcinoma diagnosis: A systematic review.

Head Neck. 2016 Nov 29;:

Authors: Stuani VT, Rubira CM, Sant'Ana AC, Santos PS

Abstract
BACKGROUND: The oral squamous cell carcinoma (OSCC) survival rate is influenced by the fact that diagnoses occur mostly in late stages of the disease. Thus, there is a clear contribution in the early findings, making the use of minimally invasive techniques for diagnosis, such as analysis of salivary markers, interesting tools.
METHODS: A systematic review was performed with all studies that establish a comparison between the levels of saliva-based markers found in patients with OSCC compared with cancer-free individuals.
RESULTS: Twenty-eight studies were included. Of them, only 12 showed some caution with oral conditions before sample collection. A wide range of potential markers was evaluated; however, the comparison between studies was impaired because each marker was hardly explored by more than 1 article.
CONCLUSION: The lack of methodological criteria within studies and the absence of consensus on marker choice are obstacles for future researches. © 2016 Wiley Periodicals, Inc. Head Neck, 2016.

PMID: 27898189 [PubMed - as supplied by publisher]

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