Altered composition of epidermal lipids correlates with Staphylococcus aureus colonization status in Atopic Dermatitis.

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Altered composition of epidermal lipids correlates with Staphylococcus aureus colonization status in Atopic Dermatitis.

Br J Dermatol. 2017 Feb 28;:

Authors: Li S, Villarreal M, Stewart S, Choi J, Indra G, Babineau DC, Philpot C, David G, Yoshida T, Boguniewicz M, Hanifin J, Beck LA, Leung D, Simpson E, Indra AK

Abstract
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by disrupted epidermal barrier functions.(1) Stratum corneum (SC) consists of corneocytes and a lipid-rich extracellular matrix, which plays a key role in epidermal permeability barrier (EPB) functions.(2,3) Major lipid constituents of the SC are ceramides (CERs), free fatty acids (FFAs), cholesterol and triglycerides (TGs).(2,3) Staphylococcus aureus (S.aureus) colonization is an important trigger of AD.(4) Comprehensive profiling of SC lipids using S.aureus colonization status, and association between S.aureus colonization and skin lipid composition, has never been documented. This article is protected by copyright. All rights reserved.

PMID: 28244066 [PubMed - as supplied by publisher]

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