Purpose of review: To perform analysis of evidence in current literature on the topic of genetics and chronic rhinosinusitis (CRS), with a particular focus on recent findings in the cystic fibrosis transmembrane regulator (CFTR), genes associated with primary ciliary dyskinesia, and taste receptor T2R38. Other genes that have been found to have association with CRS are also presented and discussed. Recent findings: Recent studies in CFTR and CRS research have investigated possible CFTR-potentiators for treatment of refractory CRS. The T2R38 gene has been shown to be applicable in the clinical setting with a testable phenotype and may have a role in the prognosis and influencing management strategies of CRS patients. Many genes of the immune system have been studied, with genome-wide association studies and candidate-gene approaches identifying new associations that will need replication and further elucidation. Summary: CRS is a multifactorial disease, with strong evidence of a genetic component in its pathophysiology for some cases. Currently, there are over 70 genes that have been genetically associated with CRS in the past 15 years. Future investigations into genetic causes and predispositions of CRS may allow for improved prognostication and development of disease-prevention strategies as well as novel therapeutic targets. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.
http://ift.tt/2ft4oEx
http://ift.tt/2fIl3EU
Ιατρική : Τα αισθητικά συστήματα της όρασης,ακοής,αφής,γεύσης και όσφρησης.
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δημοφιλείς αναρτήσεις
-
Your subscribed feeds are not being updated automatically because this setting is turned off. Turn on automatic feed updates You...
-
Pediatric Drugs Vancomycin Use in a Paediatric Intensive Care Unit of a Tertiary Care Hospital Abstract Background Vancomycin is one of the ...
-
British Journal of Oral and Maxillofacial Surgery... Stem Cells and DevelopmentMesenchymal Stem/Stroma... [ASAP] Self-Assembly of Giant Mo...
-
Journals 1a17kr-s25tv.htmlAllergy_Immunology Update from NEJM.org.eml 2az5g2-skieq.htmlAeolian Research _ Volume 42.eml 3a4c5r-hewxc.htmlAct...
-
Abstract The existing literature suggests two standpoints in defining heat intolerance, which are heat tolerance as state or trait. The fo...
-
Talon cusp on palatally erupted mesiodens : Ashalata Gannepalli, Bhargavi Krishna Ayinampudi, Shilpa Perkari, Amruta Appala, Sanjay Reddy Po...
-
SAGE Publications Inc: Technology in Cancer Rese... Latest Results for PsychopharmacologyConscious p... NEJM : ResearchRandomized Trial o...
-
Publication date: July 2016 Source: American Journal of Orthodontics and Dentofacial Orthopedics, Volume 150, Issue 1 Author(s): Nikolaos ...
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου